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Liver Disorders Flashcards

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1
Q

Liver related tests and scores?

A

Markers of hepatocelullar injury (AST, ALt, Ali Phos)

Markers metabolic function: Total Billirubin

Test of synthetic function: PT, Albumin

Test for Liver fibrosis:Fibroscan, AST Platelet Ratio Index (APRI score), Magenetic resonance Elastography

Child-Pugh: Liver function in cirrhosis patients

MELD score assess severity of ESLD and used for organ transplant allocation

Madder discriminates function score: Prognosis of alcoholic hepatitis and decide on steroid treatment

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2
Q

How should elevated liver enzymes be worked up?

A
  • If liver enzymes are > 5 times the ULN with signs and symptoms then evaluate immediately
  • If 3-5 times upper limit of normal without sign and symptoms repeat in 1-3 months
  • If < 3 without symptoms repeat in 3-6 months
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3
Q

Elevated Alkaline phosphatase workup?

A

Determine where is it coming from with a GGT or fractionated alkaline phosphatase

If the increase is from liver GGT will also be high

Once we confirm the increase Alk phos is hepatic in origin next step is to do U/S of Liver

If the U/S shows dilated ducts next is MRCP/ERCP

If U/S is normal order Antimitochondrial antibody testing, if positive consider primary biliary cholangitis and liver biopsy should be done. If its negative consider MRCP

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4
Q

how to work up elevated ALT and AST?

A
  1. Hepatitis screen
  2. U/S to look for fatty liver
  3. ANA/Anti Sm Ab to look for autoimmune hepatitis
  4. Tranferrin saturation and ferritin

If these test are negative (do second level tests)

Then check Alpha 1 antitrypsin, Ceruloplasmin, Antibody screening for celiac disease

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5
Q

What are the causes of unexplained ALT elevation?

A

Celiac Disease
Thyroid dysfunction
Muscle disorders
Adrenal Insufficiency

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6
Q

Degree of ALT elevation can help with possible underlying etiologies?

A
  1. NAFLD and Alcohol: 40-150
  2. Alcoholic hepatitis causes AST >ALT 2:1 and AST is typically < 300
  3. Acute Viral Hepatitis 500-2000
  4. Autoimmune hepatitis: 200-2000
  5. Chronic Viral Hepatitis: 40-200
  6. Drug induced- 200-1500

AST/ALT> 1000 think acute viral hepatitis, drugs, shock liver, autoimmune hepatitis, buds chiari, CBD

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7
Q

What is the MCC of Liver Failure in the US

What scoring system is used to diagnosed it?

A

Drug Induced Liver Injury (DILI)

CIOMS RUCAM score

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8
Q

What is the mcc cause of direct drug induced liver failure

What drugs cause idiosyncratic liver failure?

A

Acetaminophen (direct)

Amoxicillin/Clavulanic acid (idiosyncratic) (MCC of DILI in the US)

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9
Q

What is the MCC of Asx liver enzyme elevation?

A

NAFLD

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10
Q

What is the spectrum of NAFLD?

A

Steatosis (macrovesicular steatosis in hepatocytes)—>Steatohepatitis (NASH)—>NASH + Fibrosis—>Cirrhosis

Note: AST, ALT can be normal in both NAFLD and NASH

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11
Q

In all patients with NAFLD, what should patient be assed for?

A

Patient should be assess for Fibrosis because it is the most important predictor of liver mortality in NAFLD

We can assess with APRI score

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12
Q

What is the mcc of death in NAFLD patients?

A

Cardiovascular death

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13
Q

What’s considered significant alcohol intake?

A

Men >21 standard drink/ week

Women >14

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14
Q

What’s NASH?

A

(NASH, this is hepatic steatosis plus neutrophil, lymphocytic infiltration with hepatocellular injury around the central veins in association with Mallory bodies, and pericentral/peri sinusoidal fibrosis

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15
Q

Treatment of NAFLD

A

NO FDA proved meds

Statins are safe and reduce CVD risk

Bariatric surgery resolves NASH in 60-80 % of patients and may improve fibrosis

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16
Q

Liver biopsy is done in what high risk patients with NASH?

A 
Age >50
DM
HTN
Female
Obese
AST>45
AST/ALT ratio >0.8
Thrombocytopenia

If Liver Bx shows just fatty liver decrease calorie intake to 500 kCal/day, increase mono and polyunsaturated fatty acids in the diet, and exercise

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17
Q

What is the leading cause of crypto genie cirrhosis in the US?

A

NASH

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18
Q

What are the 4 types of inherited bilirubin disorders?

A

Unconjugated:

  1. Gilbert Syndrome: defective hepatic uptake of bilirubin
    - symptoms are apparent during periods of fasting with increased billirubin
    - Phenobarbital decrease the billirubin
    - DD is hemolysis; however, Rec count is increased in hemolysis and NL in Gilbert
    - No treatment needed
  2. Crigler-Najar- seen at birth

Conjugated:

  1. Dublin-Johnson- black liver
  2. Rotor syndrome (Liver is not pigmented)
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19
Q

In a patient with isolated increase in indirect billirunin without increase AST/ALt or Alk phos what test should be ordered next?

A

Reticulocyte count to differentiate between hemolysis and Gilbert

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20
Q

How does alcoholic hepatitis present?

How is it treated?

A

Leukocytes is
Fever
RUQ pain

GGTP is usually elevated

Treatment:

Calculate MAddrey discriminators function score

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21
Q

What is MAddrey discriminators function score equation and how is it used in alcoholic hepatitis treatment?

A

DF= (Patients PT- control PT) x 4.6+ patient’s bilirubin

If DF is > 32 mortality is 50%

In patients with alcoholic hepatitis + DF >32 with or without encephalopathy treat with Prednisolone 40 mg for 28 days

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22
Q

In patients with alcohol hepatitis with high DF when should prednisolone not be given?

A

Concomitant GI bleed, Active infection, Renal Failure, or Pancreatitis

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23
Q

How is Post exposure prophylaxis done for Hepatitis A

Which patient population is Hep A vaccination recommended

A

PEP with Ig and Vaccine within 2 weeks of contact

Vaccine recommended for people with chronic liver failure

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24
Q

Clinical progression of Hep B?

A

Starts as acute hepatitis with constitutional symptoms, malaise, arhtralgia, nausea, loss of appetite this can last 1-4 months

Majority of adults who get acute hepatitis (90-95%) have complete resolution
5% develop chronic hepatittis, can progress to cirrhosis
5% are carriers
<1% has fulminant hepatitis

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25
What serology do we see in Hep B infection during the presymptomatic prodrome phase?
Early (presymptomatic) Prodrom phase HbSAg= you are producing the virus HBeAg=infectivity HBDNA= detected by PCR during acute infection and in chronic infection with replication
26
What is the serologic test of choice when patient present with Acute SYMPTOMATIC Hep B infection?
HBcAb IgM
27
What are the 2 types of HBcAb?
HBcAb IgM= Seen in the Window period, During acute infection, and doing flare of chronic hepatitis HBcAb IgG=BEst marker for previous infection
28
What serology in Hepatitis B denotes vaccine or immunity
HBsAb If we see both HBcAg IgG and HBSAg then the immunity is due to past exposure
29
How should you workup a patient with positive Hep B surface antigen
Order Hep D DNA, HBeAg, HBeAb (antiHBe), and ALT Asymptomatic patient with: HbSAg (+), DNA (+), Increase ALT, HBeAg (+), HBeAb (-)= Chronic Hep B and should be treated HbSAg (+), DNA (+), Increase ALT, HBeAg (-), HBeAb (+)=REactivation and should be treated HbSAg (+), DNA (+), normal ALT, HBeAg (+), HBeAb (-)=High infectivity carrier, Monitor HbSAg (+), DNA (-), NL ALT, HBeAg (-), HBeAb (+)=inactive carrier, low infectivity , monitor
30
How should you workup a patient with negative Hep B surface antigen
HBSAg (-), HBSAb (-)=Vaccinated not exposed HBSAg (-), HBSAb (+) HBcAb (-)=immune due to vaccination HBSAg (-), HBSAb (+) HBcAb (+)= past infectious and immune
31
What is the preferred treatment for Hepatitis B how long is treatment continue for?
Interferon alpha Entecavir Tenofovir Oral agents are given until one of the following: HBeAg or HBSAg seroconvert to HBeAb or HBsAb Intolerable side effects Ineffectiveness Resistance Most guidelines say may discontinue after 1 year for HBeAG (+) if DNA is undetectable and HBeAG seroconversion to HBeAb occurs
32
The risk for reactivation is based on what?
``` Core Ab positivity Surface Ag (+) or (-) ``` -Very high risk of reactivation in patients with: HBSAg (+) and on anti CD 20 (rituximab)therapy or stem cell transplant -High risk HBSAg (+) and taking prednisone > 20 mg or anti CD 52 (Alemtuzumab) -Moderate risk HBSAg (+) and chemotherapy without prednisone, anti-TNF or post solid organ transplant So patients on Steroids, Rituximab, Alemtuzumab, TNF Alpha, Stem cell transplantation, SOlid organ transplant SCREEN FOR HEP B PTIENTS SHOULD START TENOFOVIR OR ENTECAVIR if moderate to high risk before starting immunosuppressive therapy and should continue for 6 months thereafter and 1year thereafter for rituximab
33
Before treating patient for hepatitis C what should be checked?
HbSAg and if positive treat with Tenofovir or Entcavir prophylactically prior to starting hep c treatment
34
Post exposure prophylaxis of hepatitis B?
1. Sexual exposure or household contact to acute HBV=Ig and Vaccination 2. Sexual exposure or household contact with chronic carrier=vaccine only 3. Percutaneous or mucosal exposure=Ig and Vac 4. Perinatal exposure= Ig and Vaccine
35
What are the extrahepatic complications of HBV that require antiviral therapy?
Polyarteritis Nodosa | Membranous Glomerulonephritis
36
Who should be screen for Hep C?
Everyone age 18-79 should be screened once for Hep C with Hepatitis C antibody regardless of risk factors If antibody is positive we then check viral load
37
To check for suspected reinfection of hepatitis C what test should be ordered?
HCV RNA only
38
What does (+) HCV Ab and negative HCV RNA indicate
REsolve infection False positivity Passively acquired or low level of viremia
39
What is the definition of chronic hepatitis?
Elevation of ALT for more than 6 months
40
Management of chronic HCV?
Abstinence from alcohol, check HIV and HBV Evaluate patient for Fibrosis with liver biopsy Check for HAV and HBV and if negative give vaccine
41
What are the 2 types of autoimmune hepatitis?
Type 1=MC seen in females mostly - Associated with (+) ANA and Anti-Smooth muscle antibody - Treated with prednisone and Azathioprine Type 2=Associated with anti LKM antibody and Anti liver cytoskeleton antibody - seen mostly in children and very rarely in adults - less responsive to steroids
42
What are the features of autoimmune hepatitis?
Bimodal age distribution Elevated ALT, AST between 1–20 and 45-70 Patient present with fatigue , abdominal pain, itching, decreased appetite, myalgia, diarrhea are common symptoms Patient CMP usually show high total protein but low albumin so The gamma globulin level is high SO you get a Hypergammaglobulinemia
43
What is the diagnostic criteria for autoimmune heapatitis?
1. Presence of autoantibodies - ANA (1)or Anti-SMA (2 points) - Anti-LKM (2) - Anti SLA (2) 2. IgG or Hypergammaglobulinemia (2) 3. Hystology compatible (1-2) 4. No viral hepatitis (2) >7= definite AIH >6=Probable AIH
44
What is the definition of Fulminant hepatic Failure? And what are the types?
Acute liver injury with hepatic encephalopathy 2 types: Hyper acute= when liver injury progresses to encephalopathy within 1 week Subacute when <12 weeks
45
What is the most common cause of fulminant hepatic failure
Acetaminophen overdose even moderate Tylenol dose in an alcoholic patient can lead to it Regularly alcoholic hepatitis should have AST and ALT less than 300 if AST is high >400 patient should be worked up for Tylenol toxicity or viral hepatitis
46
What are the complications of fulminant hepatitis?
``` Cerebral edema (mcc of death ARDS Renal failure Hypoglycemia Sepsis (mcc of death) Coagulopathy ``` When patients present with fulminant hepatitis they should be transferred to a transplant center
47
What is the typical presentation of Primary biliary Cholangitis?
Disease of the Interlobular bile ducts, seen mostly in women Present with Fatigue, Pruritus, Xanthelasma due to hyperlipidemia Jaundice, steatorrhea Labs show: elevated Alkaline phosphatase and Anti-mitochondrial Ab U/S wont show dilated ducts Note if AMA is negative in woman or prior to diagnosing PBC in men cholangiogram (MRCP) is done to rule out Primary sclerosis’s good cholangitis
48
What is an important extrahepatic complication of primary biliary cholangitis?
Osteoporosis
49
What is the treatment of primary biliary cholangitis?
Pruritus= hydoxizine, lubrication, cholestyramine Ursodiol=slows disease progression At Child Pugh B score place patient on transplant list Obeticholic acid is given if patient doesn’t not respond to Ursodiol or in combo with it or a mono therapy if patient cant tolerate ursodiol
50
How does Primary Sclerosing cholangitis present?
Diffuse fibrosis inflammatory disease of the biliary duct Commonly seen in men Associated with Ulcerative colitis (80%) P-ANCA positive as well ass ANA and ANti SM So when Alk phos is elevated in a male MRCP should be done
51
what does MRCP show in Primary sclerosing cholangitis?
Narrowing and dilation of the biliary tree If MRCP shows biliary obstruction then ERCP is done to make sure there’s no cholangiocarcinoma If PSC is suspected and cholangiography is negative follow it up with biopsy for possible small duct PSC
52
What are the complication of Liver Cirrhosis?
In cirrhosis there is elevated portal pressure the normal pressure gradient between the portal vein and hepatic vein is 3-6 mmHg >6 is considered Portal HTN Ascites develop at gradients > 10 Esophageal Varices occur at gradients >10and bleed at > 12 -Cirrhotic patient should be screened every 2-3 yrs with EGD
53
What are the diet recommendations for cirrhosis patients?
- Diet to achieve a BMI of 20-25 - Vitamin D supplement - Protein restriction is no longer recommended because there is defective gluconeogensis so muscle are broken done during the night for energy. So these patients are recommended to be on 1.2-1.5 gram/kg of protein per day every if there is hepatic encephalopathy - cirrhosis and elevated PT/INR does not confer protection against VTE and hospitalized patients should be prophylactically treated unless INR>3 - Avoid Narcotics, Benzos and NSAIDS in cirrhosis patients - consider trazodone or hydroxyzine for insomnia
54
What does SAAG indicate?
>1.1=portal HTN= Cirrhosis, RHF, Budd chiari <1.1=nephrotic syndrome, malignancy, TB
55
Treatment of Ascites?
-Salt Restriction of 2g per day A 24 hr urine sodium > 90 indicates noncompliance - Water restriction only if sodium is <125 - No protein restriction Spirinolactone + Lasix. Midodrine can be added if patient have diuretic resistant ascites in association with hypotension
56
what medication worsen surgical in refractory ascites?
BB ACEI/ARB they decrease renal perfusion they should be stopped when cirrhotic patients develop hypotension
57
what 3 scenarios in a cirrhosis patient do we need to stop BB?
1. Refractory Ascites 2. Cirrhosis patient with Hypotension (<100) 3. Even One occurrence of SBP (BB d/c permanently) Once BB is stopped Banding should be considered for Varices
58
When is therapeutic paracentecis perform for ascites?
1. Symptomatic large ascites 2. Ascites unresponsive to diuretics When > 5L of ascetic fluid is removed give patient 25g Albumin per %L of ascetic fluid
59
What therapy is available for refractory ascites?
Peritoneal venous shunt and TIPS Midodrine (may improve renal function)
60
What intervention have been shown to improve transplant free survival in cirrhosis patients?
TIPS
61
When should IV albumin be given in a patient with SBP?
IV 25% albumin should be given when: Creating is >1 BUN >30 Or Billirubin total is >4 (1.5g/kg is given at diagnosis and 1 g/kg on day 3)
62
What medication do we use for prophylaxis against SBP?
Cirrhosis patients with Variceal bleed should get IV Ciprofloxacin to prevent SBP Patients with history of SBP get with Norfloxacin or Bactrim
63
What are the indication primary prophylaxis against SBP with Nofloxacin?
Cirrhosis patients with Ascites with fluid protein <1.5 g/dL Impaired renal function Serum Sodium <130 Child Pugh >9
64
How doe we diagnose Hepatorenal syndrome?
Patient with cirrhosis and ascites with a serum creatinine >1.5 mg/dL we stop their diuretic and give them IV Albumin if no improvement of the creative after 2 days of stopping the diuretic Typically Urine sodium is <10
65
What are the 2 types of Hepatorenal syndrome?
Type 1:Develops rapidly and usually precipated by GI bleed or infection Type 2: more slow onset, seen in patient with persistent ascites
66
How is Hepatorenal syndrome treated?
Type 1= Midodrine+ IV albumin +Octreotide Type 2= liver transplant
67
What is portopulmonary HTN? how is it treated? what is Hepatopulmonary syndrome?
This is Pulm Arterial HTN in patients with portal HTN and no other etiology Treated with sildenafil, epoprostenol, bosentan Liver transplant is done for patients with Pulm artery pressure <50 mmHg Hepatopulmonary syndrome is seen in advance liver disease with hypoxia (PaO2 <80) or AA >15mmhg; patient complains of platypuses (oxygenation improves lying flat), Orthodeoxia
68
Hepatopulmonary syndrome is Dx by what?
Echo with bubble study and is positive if we see bubbles in LA after 4-5 cardiac cycles or macroaagregated albumin NM Scan
69
Primary prevention of variceal bleeding is?
No selective BB )propranolol or nadolol) If pt cant tolerate BB because of hypotension then endoscopic band ligation can be done BB blocker do not prevent formation of Varices its just prevent them from bleeding once they already form
70
what medication can we use for treatment of hepatic encephalopathy
Lactulose and Riifaximin
71
who do we screen for HCC? What screening modality are used
1. Hep B patients with one of the following : - Asian male >40 - Asian Female >50 - African American >20 - Hep B with cirrhosis - Hep with fhx HCC 2. Cirrhosis of any etiology U/S every 6 months If U/S not available then AFP
72
How does HCC present?
RUQ pain, Weight loss, Ascites A serial triphasic CT that shows a lesion with enhancement during arterial phase alongside elevated AFP is enough to Dx without getting biopsy
73
how is HCC. Treated?
Solitary lesion < 5 cm or <3 lesions each < 3cm=liver transplant
74
When to refer patients for liver transplant?
MELD >10 Child Pugh >7 Evidence of decompensated cirrhosis: AScites, SBP, Encephalopathy, Variceal bleed

Gastroenterology (4 decks)

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