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Clin Chem 2 > Liver Function Tests > Flashcards

Liver Function Tests Flashcards

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1
Q

Give me 4 excretory function tests for LFT

A
  1. Test for urobilinogen and other bilirubin pigments
  2. Icterus Index
  3. Dye Excretion Tests (BSP, ICG)
  4. Serum Bilirubin
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2
Q

ENUMERATE METABOLIC FUNCTION TESTS

A
  1. Carbohydrate Metabolism
  2. Galactose tolerance test
  3. OGTT
  4. Protein Metabolism
  5. TP, A/G ratio
  6. cephalin cholesterol floccculation test
  7. Thymol Turbidity Test
  8. HIppuric acid test
  9. Lipid Metabolism
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3
Q

Parenchymal Liver Markers (6)

A

ALT, AST, AST/ALT (De Ritis Ratio) - LDH, ICC (isocitrate dehydrogenase), OCT (ornithine carbamolytransferase).

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4
Q

Indicators of hepatobiliary disorders- NON- parenchymal markers (4)

A

ALP, GGT, 5’ Nuleotidase, LAP

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5
Q

Typical lab findings in acute hepatitis of various causes (5)

A
  1. Viral
  2. Alcoholic
  3. Ischemic/Toxic
  4. Drug-induced (iatrogenic)
  5. Autoimmune
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6
Q

PEAK AST and ALT

A

Ischemic/Toxic

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7
Q

Less than 1 AST/ALT Ratio

A

Viral, Drug-induced, and Autoimmune

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8
Q

GREATER than 1 AST/ALT ratio
- HIgher AST than ALT

A

Alcoholic and Ischemic or Toxic

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9
Q

Longest duration among the acute hepatitis causes

A

Autoimmune

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10
Q

PEAK ALP less than 3 URL

A

Viral and alcoholic

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11
Q

PEAK ALP LESS THAN 1.5 URL

A

Ischemic or toxic

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12
Q

PEAK ALP GREATER THAN 3 URL

A

Drug-induced abd autoimmune

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13
Q

8 TESTS FOR BILIRUBIN

A
  1. Evelyn- Malloy
  2. Jendrassik and grof
  3. Anino,Ducci and Watson
  4. Stoner and Wiseberg
  5. Modified Michaelson
  6. Thamhauser and Anderson
  7. Alkaline methanolysis
  8. Icterus Index
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14
Q

Technique used in Evelyn- Malloy and Jendrassik and Grof

A

AZOBILIRUBIN TECHNIQUE

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15
Q

What is needed to be mixed so that the IB is solubilize

A

Methanol- (Evelyn- Malloy)
Caffeine-sodium benzoate (JG)

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16
Q

Calculated from the difference between the TB and DB values

A

IB fraction

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17
Q

The diazotized product of EM method

A

BILIRUBIN-DIAZOTIZED SULFANILIC ACID

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18
Q

EM or JG: Red to reddish-purple color in an acid pH (HCl)

19
Q

EM OR JG: the product has an absorption maxium at 560 nm

20
Q

EM OR JG: Methanol is used as a disassociating agent

21
Q

What is the buffer and coupling accelerator used in JG method

Study These Flashcards
A

Sodium acetate (buffer)
Sodium benzoate (coupling accelerator)

22
Q

How is diazotization terminated in the JG method?

Study These Flashcards
A

By adding ascorbic aciid

23
Q

EM OR JG: with the use of a STRONG ALKALINE TARTRATE solution, THE PINK AZOBILIRUBIN is then converted to a BLUE AZOBILIRUBIN

24
Q

Defect in uptake (B1 is elevated)

Study These Flashcards
A

GILBERT SYNDROME

25
Defect in hepatic glucuronyl transferase (B1 is elevated)
CRIGLER NAJJAR SYNDROME
26
Defect in transport extracellularly (B2 is elevated)
DUBIN-JOHNSON SYNNDROME
27
Causes of HYPERBILIRUBINEMIA increased unconjugated bilirubin
Hemolysis Red cell degradation Defective hepatocellular uptake
28
INCREASED CONJUGATED BILIRUBIN
Intrahepatic disruption Bile duct disease Extrahepatic bile duct obstruction
29
Screening Test for Nonalcoholic fatty liver disease (NAFLD)
Ultrasonography
30
Confirmatory test for NAFLD
BIOPSY
31
-Screening test for hemochromatosis -Confirmatory test?
-Serum Fe, TIBC, ferritin -HFE gene analysis
32
Screening and Confirmatory Test for Wilson's Disease
S: Ceruloplasmin, serum/urine Cu C: Liver biopsy, genetic studies
33
Autoimmune hepatitis screening and confirmatory test
S: anti-nuclear Ab (ANA), anti-smooth muscle, Ab (ASMA) C: Liver biopsy
34
Chronic hepatitis diseases:
Hepatitis B, Hepatitis C, NAFLD, Hemochromatosis Wilson's disease, Autoimmune hepatitis
35
Genetic diseases of the liver
1. Alpha 1-antitrypsin deficiency 2. Criggler-Najjar syndrome 3. Dubin-Johnson syndrome 4. Gilbert's syndrome 5. Hemochromatosis 6. Wilson's disease
36
Gene affected in alpha1-antritrypsin
SERPIN1 (Pi)
37
Criggler Najjar gene and protein product
UGTA1 Product: UDP- gucuronyl transferase 1
38
DBJ gene and protein product
COMOAT PRODUCT: canalicular multispecific organic transporter
39
Gilbert's syndrome gene and protein product respectively
UGTA1 (promoter), UDP- glucuronyl transferase 1
40
Hemochromatosis gene and protein product
HFE, HFE protein
41
Wilson's disease gene and protein product
ATP7B PRODUCTS: ATPase, Cu(2+) transporting beta polypeptide
42
5 anatomical infos about hepatic system
1. Liver is a reddish-brown organ with two lobes. 2. Gallbladder is a small, pear-shapeorgan on the right side of your abdomen, just beneath your liver. 3. Falciform is a thin, flat ligament attaching the liver to the diapraghm. 4. Hepatocytes are polygonal liver cells arranged in plates. 5. Portal triad are composed of three major tubes.
43
The functional units of the liver is the a
ACINUS

Clin Chem 2 (2 decks)

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