Flashcards in Liver: Hepatitis Deck (19):
Commonly from travelers
Common from contaminated water or undercooked seafood
HAV and HEV
HAV and HEV produce an acute hepatitis with NO chronic state
HEV is particularly dangerous in what patient population?
Associated with fulminant hepatitis (liver failure with massive necrosis)
(Childbirth, unprotected intercourse, IVDA)
Acute hepatitis that develops to chronic in 20% of cases
What does the presence of HBsAG tell you?
It is the key marker for infection. If it is positive for longer than 6 months, the infection is chronic
When the infection is resolved, HBsAG should become negative
What does the presence of HBcAB tell you? What kind of antibody is it?
IgM is the acute and window marker.
Indicates acute HV infection
What does the presence of HBsAB tell you?
Indicates resolved HBV infection (it is IgG against the surface antigen) or a protected, immunized individual
What does the presence of HBeAG and HBV DNA tell you?
The person is infectious
e antigen --> envelope
Parenteral (IVDA, unprotected intercourse, needle stick)
Why is transfusion risk of HCV infection very low?
The blood supply is screened for HCV
Results in acute hepatitis and chronic disease in most cases
What is measured to measure progression of the disease?
HCV RNA will confirm the infection. Levels should decrease as recovery occurs. Persistence indicates chronic disease
How does it infect patients?
HDV cannot infect patients on its own.
Needs either superinfection or coinfection with HBV
Viral Hepatitis is usually due to the hepatitis virus, but what other viruses can cause it?
EBV and CMV
Signs of acute hepatitis infection
Jaundice (mixed CB and UCB) with dark urine (CB)
Elevated liver enzymes (ALT > AST)
Inflammation in portal tracts and within hepatocytes
How long does acute hepatitis last? How long does chronic hepatitis last?
Acute is less than 6 months
Chronic is greater than 6 months