Flashcards in Liver injury Deck (12):
What does the liver do?
Glucose + fat metabolism
Detoxification + excretion
Defence against infection
What proteins does the liver synthesise?
What things does the liver detoxify and excrete?
Bilirubin (breakdown of haem)
What's the difference between acute and chronic liver injury?
Acute: one of attack on the liver, the liver returns to normal after
Chronic: attack every day for years takes a toll on the liver, it regenerates but not very well
What are the outcomes of acute liver injury?
Chronic liver injury
What can chronic liver injury result in?
What would you see on a liver biopsy of someone with acute liver injury?
Apoptosis and necrosis of cells
Influx of neutrophils
What would you see on a liver biopsy of someone with chronic liver injury?
Damaged hepatocytes and other cells
Scarring, leaving islands of hepatocytes amongst the scar tissue
What causes acute liver injury?
What causes chronic liver injury?
Metabolic: iron, copper
Presentation of acute liver injury?