Liver injury Flashcards Preview

Liver > Liver injury > Flashcards

Flashcards in Liver injury Deck (12):
1

What does the liver do?

Glucose + fat metabolism

Detoxification + excretion

Protein synthesis

Defence against infection

2

What proteins does the liver synthesise?

Albumin
Clotting factors

3

What things does the liver detoxify and excrete?

Bilirubin (breakdown of haem)
Ammonia
Drugs
Hormones
Toxins

4

What's the difference between acute and chronic liver injury?

Acute: one of attack on the liver, the liver returns to normal after

Chronic: attack every day for years takes a toll on the liver, it regenerates but not very well

5

What are the outcomes of acute liver injury?

Recovery
Liver failure
Chronic liver injury

6

What can chronic liver injury result in?

Recovery
Cirrhosis
Liver failure

7

What would you see on a liver biopsy of someone with acute liver injury?

Apoptosis and necrosis of cells
Influx of neutrophils

8

What would you see on a liver biopsy of someone with chronic liver injury?

Damaged hepatocytes and other cells

Scarring, leaving islands of hepatocytes amongst the scar tissue

9

What causes acute liver injury?

Viral hepatitis
Drug
Alcohol
Vascular, ischaemia
Obstruction
Congestion

10

What causes chronic liver injury?

Alcohol
Viral
Autoimmune
Metabolic: iron, copper

11

Presentation of acute liver injury?

Malaise
Nausea
Anorexia
Jaundice

Confusion
Bleeding
Liver pain
Hypoglycaemia

12

Presentation of chronic liver injury?

Ascites
Oedema
Haematemesis due to varices
Malaise
Anorexia
Wasting
Easy bruising
Itching
Hepatomegaly
Jaundice
Confusion