Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Lymphatic System > LN > Flashcards

LN Flashcards

(72 cards)

Start Studying
1
Q

Function of LN

A

-Drain protein containing fluid that escapes from blood capillaries.
-Transport fats from GI tract to the blood
Produce lymphocytes
-Develop immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Lymph flows into LN through the?

A

Afferent vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Lymph flows out of LN through?

A

Efferent Vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are small bean shaped structures lying along the course of lymphatics?

A

Lymph Nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Where can the primary LN follicle be found?

A

Germinal Center

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the 3 components that makes up the node?

A

-lymphatic sinuses
-blood vessels
-parenchyma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the thin capsule around node made up of?

A

Fibroblast & collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Space under capsule is called?

A

Subcapsular sinuses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Should a LN have epithelium? If so, explain what it’s presence means

A

No, if it is present then sus mets ca

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

—- is known as the T cell house

A

Paracortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Where are plasma cells & macrophages plentiful?

A

Medulla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Primary & secondary follicles are found here

A

Cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

B cells enter the LN through?

A

High Endothelial Venules (HEVs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Activated B cells within lymphoid follicles are known as?

A

Follicular Center Cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

B cells that have cleaved nuclei are called?

A

Centrocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Non-cleaved cells with larger more open nuclei & several nucleoli?

A

Centroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Stimulated mature B cells responding to an antigen change into — & then —- which then leave follicle & pass to —- & —-

A

Centroblasts, centrocytes, paracortex, medullary sinuses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

After leaving follicles, B cells become —- which divide to give rise to plasma cells or memory B cells.

A

Immunoblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Where does B cell maturation occur?

A

Germinal Center

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

B cells undergo their development in —- while T cells in the —-

A

Bone marrow, Thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

If something went wrong during phase at bone marrow – abnormal cells are being made there (primary lymphoid organ), it results in —-?

A

Leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

If there is something that goes wrong in secondary lymphoid organ —?

A

Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What cells are numerous in paracortex & acts as APCs?

A

Dendritic Cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Paracortical T-cells, mostly —- are key players in the recognition of antigen.

A

CD4(+) T-helper cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
The B-cells that survive the tumultuous, Darwinian struggle within the germinal center eventually differentiate into ----
Plasma Cells
26
What cells can be found in cortex?
B Cells Macrophages Follicular Dendritic Cells****
27
Paracortex has what kind of cells present?
T Cells Immunoblasts Langerhans's Cells
28
Plasma cells Immunoblasts Plasmacytoid Lymphocytes Rare macrophages can be found where?
Medulla
29
Resting or mature 65-90% of cell population Round nucleus (generally) Smooth membrane Hyperchromatic, coarse, even chromatin Thin rim of cytoplasm Nucleoli- absent to inconspicuous
Small Lyc
30
10 to 12 microns in size Round with a cleaved membrane Thin rim of cytoplasm Absent to inconspicuous nucleoli
small cleaved centrocytes
31
20 to 40 microns Cleaved angulated nuclei Coarse chromatin, even distribution Inconspicuous nucleoli
Large Cleaved Lyc
32
First sign of antigenic stimulation 20 to 40 microns Round vesicular nuclei 1-3 prominent peripheral nucleoli Moderate, basophilic cytoplasm
Small/large centroblast
33
Before B cells become plasma cells, they are ---?
Immunoblasts
34
Large nuclei Prominent central macronucleolus or: 2 or more nucleoli (T Type) Plasmacytoid cytoplasm Irregular membrane Occasional plasmacytoid cytoplasm and perinuclear
Immunoblasts (B or T cell)
35
Specialized histiocytes Antigen presenting Stromal Long Cytoplasmic processes Non phagocytic Part of reticular network of lymph node
Follicular Dendritic Cells
36
Contain bits of B-cells (failure to bind antibody to antigen) Seen mostly in benign conditions**** CAN be seen in aggressive (high grade) lymphomas
Tingible Body Macrophages (TBM)
37
Represent reticulum cells in follicles & germinal centers. In aspirates, these form large structures that can be in flat, loose sheets or cohesive 3-D cell clusters. Cytoplasm is abundant, pale, ill-defined and delicate
Lympho-histiocytic Aggregate in LN FNA
38
Enlarged nodes(<3 cm in diameter), usually NOT tender Common in the inguinal, axillary, and cervical regions because these lymph nodes drain large areas The FNA is quite cellular MOST COMMON DIAGNOSIS IN FNA
CHR Lymphadenitis (Rx LN)
39
Polymorphous Small lymphoid cells May see plasma cells and immunoblasts Tingible body macrophages - High range of maturation - Lymphohistiocytic aggregates Key: POLYMORPHOUS
Rx LN
40
What is the dx for: Polymorphic population, Morphologic Diversity Lymphoglandular bodies in the bkg
Rx LN
41
These aggregates create the appearance of an epithelioid group of cells.
Lymphoid Tangles in LN FNA
42
Lymphoid globules or hyaline bodies that are detached blebs of lymphocyte cytoplasm
Lymphoglandular Bodies
43
Cat Scratch is caused by --- and can be stained with ---?
Bartonella hensalae, silver stain
44
Lump that develops at the collar bone
Branchial Cleft Cyst
45
Freely movable beneath the skin Tender Less firm Arising and subsiding over weeks or months PAIN
Rx Adenopathy
46
Matted Non-tender Stony hard if fibrosis is present Slowly, inexorably growing
Malignant Adenopathy
47
----- are clonal, uncontrollably expanding, destructive proliferations of lymphoid cells.
Lymphoma
48
Lymphoid neoplasms that predominantly involve the bone marrow and peripheral blood are considered
Leukemia
49
CD34, TdT, CD117
Markers for Immature Cells
50
CD3, CD5, CD4, CD8, CD7
T cell Markers
51
CD19, CD20, CD79a, PAX-5
B cell markers
52
CD38, CD138, CD79a
Plasma Cell markers
53
Dx for a mixed population of small lyc + large cells
Rx Node, Follicular Lymphoma
54
Dx of small cell pattern of lyc
SLL/CLL, Mantle Cell Lymphoma
55
What cells have large bright red nucleolus surrounded by clear zone & what condition are the found in?
Reed Sternberg Cells, Hodgkin's Lymphoma
56
Much less common than classical type incidence Usually, males between 30-50 Malignant cells are monoclonal B cells: L & H cells, large cells w/ one large multilobate, folded nucleus. Their contorted nuclear shape gives the name “popcorn cells” Smaller than typical RS cells w/ smaller nucleoli (-) for CD30, CD15 (+) for CD20 & CD45 and 50% show + EMA
Nodular Lymphocyte predominant HL
57
Reed Sternberg stains (+) for which markers but doesn't stain the lyc in the bkg
CD15 & CD30
58
What dx is: -Seen mostly in young adult male Abundant cellularity: -RS cells - Hodgkin’s cells -Lymphs -Eosinophils -Plasma cells -Macrophages
HL; mixed cellularity
59
Seen in more young females Fibrous tissue (fibroblasts) Few RS & Hodgkin’s cells Few Lymphs Popcorn cells May be confused w/ granulomatous lymphadentitis => Nodular bands of tissue are filled w/ fibroblasts – hard lymph nodes
HL - Nodular Sclerosing Type
60
Lymph flows into LN through ---- vessels & out through ----
narrow, wider
61
Most of the fluid collects in main channel for lymphatic drainage called ---?
Thoracic duct
62
2 very important streams for lymphatic flow; contributes about 40% of fluid that gets into thoracic duct
Liver & intestine
63
T cells either release ---- to kill invaders or activate the ----- to do the killing
cytokines, APCs (macrophages)
64
Maturity of B cells:
Centroblasts => centrocyte => Immunoblasts (paracortex & medullary sinus) => plasma cells
65
Paracortical T-cells, mostly ------- cells, are key players in the recognition of antigen.
CD4(+) T-helper
66
------ have larger and more empty-appearing nuclei, the germinal centers show up as pale disks in the cortex on H&E stained slides.
Activated B-cells
67
They are thought to represent the reticulum cells in follicles and germinal centers.
Lympho-histiocytic aggregate
68
It is characterized by a t(11;14) translocation involving the cyclin D1 gene (cell cycle).
Mantle Cell Lymphoma
69
Immunophenotype (CD10+), cytogenetic (t(14;18)), and constitutively over-express the Bcl-2 gene (B-Cell Lymphoma ) that blocks apoptosis. 40% progress to Diffuse Large B-Cell Lymphoma (TP53 gene mutation) -½ can transform into large B cell lymphoma
Follicular Lymphoma
70
Activates c-myc oncogene Has an endemic form found in Africa (EBV); sporadic form found in US (both in children) CD19, CD20 positive, CD10 also may be positive Characteristics t(8:14) translocation
Burkitt's Lymphoma
71
--- stains the Epstein's Barr Body in --- lymphoma
EBER, Burkitt's Lymphoma
72

Lymphatic System (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions