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Anesthesia Pharm > Local Anesthetics > Flashcards

Local Anesthetics Flashcards

1
Q

Esters

A

Procaine
Chloroprocaine
Tetracaine

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2
Q

Which Ester is most potent?

A

Tetracaine

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3
Q

Which Ester has the most rapid onset?

A

Chloroprocaine

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4
Q

Duration after Infiltration: Procaine

A

45-60min

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5
Q

Chloroprocaine: Duration after infiltration

A

30-45min

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6
Q

Tetracaine: Duration after Infiltration

A

60-180min

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7
Q

Procaine: max single dose for infiltration

A

500mg

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8
Q

Chloroprocaine: max single dose for infiltration

A

600mg

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9
Q

Tetracaine: max single dose for infiltration

A

100mg (topical)

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10
Q

Procaine pK

A

8.9

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11
Q

Chloroprocaine pK

A

8.7

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12
Q

Tetracaine pK

A

8.5

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13
Q

Amides

A

Lidocaine
Prilocaine
Mepivacaine
Bupivacaine
Levobupivacaine
Ropivucaine

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14
Q

Lidocaine: Duration after infiltration

A

60-120min

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15
Q

Prilocaine: duration after infiltration

A

60-120min

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16
Q

Mepivacaine: duration after infiltration

A

90-180min

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17
Q

bupivacaine, levobupivacaine, & ropivacaine duration after infiltration

A

240-480min

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18
Q

Benzocaine Onset & Duration

A

onset: rapid
duration: 30-60min

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19
Q

Cocaine peak & duration

A

peak: 30-45min
duration: 60min after peak

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20
Q

Lidocaine: max single dose for infiltration

A

300mg

w/ epi: 500mg

spinal: 100mg

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21
Q

Prilocaine: max single dose for infiltration

A

400mg

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22
Q

mepivacaine: max single dose for infiltration

A

300mg

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23
Q

Bupivacaine & Levobupivacaine: max single dose for for infiltration

A

175mg

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24
Q

Ropivacaine: max dose for single infiltration

A

200mg

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25
Q

Lidocaine & prilocaine pK

A

7.9

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26
Q

Mepivacaine pK

A

7.6

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27
Q

Bupivacaine, levobupivacaine, ropivacaine pK

A

8.1

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28
Q

Benzocaine pK

A

WEAK ACID - pKa 3.5

29
Q

Procaine % protein bound

A

6%

30
Q

Tetracaine % PB

A

76%

31
Q

Lidocaine % PB

A

70%

32
Q

Prilocaine % PB

A

55%

33
Q

Mepivacaine % PB

A

77%

34
Q

Bupivacaine % PB

A

95% alpha1 acid glycoprotein

35
Q

levobupivacaine % PB

A

97%

36
Q

Ropivacaine % PB

A

94% alpha1 acid glycoprotein

37
Q

Procaine lipid solubility

A

0.6

38
Q

Tetracaine lipid solubility

A

80

39
Q

lidocaine lipid solubility

A

2.9

40
Q

Prilocaine lipid solubility

A

0.9

41
Q

Mepivacaine lipid solubility

A

1

42
Q

Bupivacaine lipid solubility

A

28

43
Q

Procaine E 1/2 time:

A

9 minutes

44
Q

Chloroprocaine E 1/2 time:

A

7 minutes

45
Q

Lidocaine & Prilocaine E 1/2 time:

A

96 minutes

46
Q

Mepivacaine E 1/2 time:

A

114 minutes

47
Q

Bupivacaine E 1/2 time:

A

210 minutes

48
Q

Levobupivacaine E 1/2 time:

A

156 minutes

49
Q

Ropivacaine E 1/2 time:

A

108 minutes

50
Q

Lidocaine, Prilocaine, and Mepivacaine Toxic Plasma levels

A

> 5mcg/mL

51
Q

Bupivacaine toxic plasma level

A

> 3mcg/mL

52
Q

Ropivacaine toxic plasma level

A

> 4mcg/mL

53
Q

Epi 1:200,000

A

5mcg/mL

54
Q

Epi 1:500,000

A

2mcg/mL

55
Q

Epi 1:10,000

A

100mcg/mL

56
Q

Epi 1:1,000

A

1000mcg/mL

57
Q

LA 0.25%

A

2.5mgs/mL

58
Q

LA 0.5%

A

5mgs/mL

59
Q

LA 1%

A

10mgs/mL

60
Q

LA 2%

A

20mgs/mL

61
Q

LA 4%

A

40mgs/mL

62
Q

Lidocaine Regional Max Dose

A
  1. 5mg/kg
  2. w/ epi: 7mg/kg
63
Q

Prilocaine Regional Max Dose

A
  1. 6mg/kg
  2. w/ epi: 8.5mg/kg
64
Q

Mepivacaine Regional Max Dose

A
  1. 5mg/kg
  2. w/ epi: 7mg/kg
65
Q

Bupivacaine Regional Max Dose

A
  1. 2.5mg/kg
  2. w/ epi: 2.5mg/kg
66
Q

Ropivacaine Regional Max Dose

A
  1. 3mg/kg
  2. w/ epi: 4mg/kg
67
Q

Procaine Regional Max Dose

A
  1. 7mg/kg
  2. w/ epi: 8.5mg/kg
68
Q

Chloroprocaine Regional Max Dose

A
  1. 6mg/kg
  2. w/ epi: 14mg/kg
69
Q

Tetracaine Regional Max Dose

A
  1. 3mg/kg
  2. w/ epi: 3mg/kg

Anesthesia Pharm (1 decks)

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