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Anesthesia Pharm > Local Anesthetics > Flashcards

Local Anesthetics Flashcards

1
Q

Esters

A

Procaine
Chloroprocaine
Tetracaine

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2
Q

Which Ester is most potent?

A

Tetracaine

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3
Q

Which Ester has the most rapid onset?

A

Chloroprocaine

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4
Q

Duration after Infiltration: Procaine

A

45-60min

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5
Q

Chloroprocaine: Duration after infiltration

A

30-45min

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6
Q

Tetracaine: Duration after Infiltration

A

60-180min

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7
Q

Procaine: max single dose for infiltration

A

500mg

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8
Q

Chloroprocaine: max single dose for infiltration

A

600mg

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9
Q

Tetracaine: max single dose for infiltration

A

100mg (topical)

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10
Q

Procaine pK

A

8.9

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11
Q

Chloroprocaine pK

A

8.7

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12
Q

Tetracaine pK

A

8.5

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13
Q

Amides

A

Lidocaine
Prilocaine
Mepivacaine
Bupivacaine
Levobupivacaine
Ropivucaine

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14
Q

Lidocaine: Duration after infiltration

A

60-120min

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15
Q

Prilocaine: duration after infiltration

A

60-120min

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16
Q

Mepivacaine: duration after infiltration

A

90-180min

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17
Q

bupivacaine, levobupivacaine, & ropivacaine duration after infiltration

A

240-480min

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18
Q

Benzocaine Onset & Duration

A

onset: rapid
duration: 30-60min

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19
Q

Cocaine peak & duration

A

peak: 30-45min
duration: 60min after peak

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20
Q

Lidocaine: max single dose for infiltration

A

300mg

w/ epi: 500mg

spinal: 100mg

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21
Q

Prilocaine: max single dose for infiltration

A

400mg

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22
Q

mepivacaine: max single dose for infiltration

A

300mg

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23
Q

Bupivacaine & Levobupivacaine: max single dose for for infiltration

A

175mg

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24
Q

Ropivacaine: max dose for single infiltration

A

200mg

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25
Lidocaine & prilocaine pK
7.9
26
Mepivacaine pK
7.6
27
Bupivacaine, levobupivacaine, ropivacaine pK
8.1
28
Benzocaine pK
WEAK ACID - pKa 3.5
29
Procaine % protein bound
6%
30
Tetracaine % PB
76%
31
Lidocaine % PB
70%
32
Prilocaine % PB
55%
33
Mepivacaine % PB
77%
34
Bupivacaine % PB
95% alpha1 acid glycoprotein
35
levobupivacaine % PB
97%
36
Ropivacaine % PB
94% alpha1 acid glycoprotein
37
Procaine lipid solubility
0.6
38
Tetracaine lipid solubility
80
39
lidocaine lipid solubility
2.9
40
Prilocaine lipid solubility
0.9
41
Mepivacaine lipid solubility
1
42
Bupivacaine lipid solubility
28
43
Procaine E 1/2 time:
9 minutes
44
Chloroprocaine E 1/2 time:
7 minutes
45
Lidocaine & Prilocaine E 1/2 time:
96 minutes
46
Mepivacaine E 1/2 time:
114 minutes
47
Bupivacaine E 1/2 time:
210 minutes
48
Levobupivacaine E 1/2 time:
156 minutes
49
Ropivacaine E 1/2 time:
108 minutes
50
Lidocaine, Prilocaine, and Mepivacaine Toxic Plasma levels
>5mcg/mL
51
Bupivacaine toxic plasma level
>3mcg/mL
52
Ropivacaine toxic plasma level
>4mcg/mL
53
Epi 1:200,000
5mcg/mL
54
Epi 1:500,000
2mcg/mL
55
Epi 1:10,000
100mcg/mL
56
Epi 1:1,000
1000mcg/mL
57
LA 0.25%
2.5mgs/mL
58
LA 0.5%
5mgs/mL
59
LA 1%
10mgs/mL
60
LA 2%
20mgs/mL
61
LA 4%
40mgs/mL
62
Lidocaine Regional Max Dose
1. 5mg/kg 2. w/ epi: 7mg/kg
63
Prilocaine Regional Max Dose
1. 6mg/kg 2. w/ epi: 8.5mg/kg
64
Mepivacaine Regional Max Dose
1. 5mg/kg 2. w/ epi: 7mg/kg
65
Bupivacaine Regional Max Dose
1. 2.5mg/kg 2. w/ epi: 2.5mg/kg
66
Ropivacaine Regional Max Dose
1. 3mg/kg 2. w/ epi: 4mg/kg
67
Procaine Regional Max Dose
1. 7mg/kg 2. w/ epi: 8.5mg/kg
68
Chloroprocaine Regional Max Dose
1. 6mg/kg 2. w/ epi: 14mg/kg
69
Tetracaine Regional Max Dose
1. 3mg/kg 2. w/ epi: 3mg/kg

Anesthesia Pharm (1 decks)

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