Logical Approach to Diarrhea in Dogs and Cats Flashcards

1
Q

What can diarrhea commonly be confused with (by owner usually)?

A

Can be confused with constipation (straining)

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2
Q

How do you classify diarrhea?

A

Acute vs Chronic
Small bowel vs. large bowel vs. mixed

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3
Q

How do you usually treat acute diarrhea?

A

Symptomatically

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4
Q

How do you usually treat chronic diarrhea? What proportion of cases are in specialty vs general practice?

A

Requires investigation - complicated causes
Small proportion in GP, high proportion in specialty

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5
Q

Why is a thorough history essential for patients with diarrhea?

A

Physical exam often unremarkable

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6
Q

Describe small bowel vs. large bowel diarrhea consistency/appearance/color

A

Small bowel - soft, typical diarrhea, MUCOUS (irritation), NO FRANK BLOOD, digested blood (melena)
Large bowel - frank blood indicates large bowel issue,

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7
Q

Is frank blood or melena a sign of a bigger issue?

A

MELENA - BIG PROBLEM

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8
Q

Weight loss in small bowel vs. large bowel diarrhea?

A

Small bowel - can occur, but doesn’t have to
Large bowel - no weight loss, as digestion of nutrients occurs in SI (in small animals)
*Opposite in horses

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9
Q

Vomiting in in small bowel vs. large bowel diarrhea?

A

Small bowel - vomiting receptors in SI, common
Large bowel - usually no, but can be associated with inflammatory bowel disease

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10
Q

What are some physical signs seen in the patient in small bowel vs. large bowel diarrhea?

A

Small bowel - borborygmus, flatulence
Large bowel - tenesmus (straining, very uncomfortable) *can also occur in SI diarrhea

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11
Q

Frequency in small bowel vs. large bowel diarrhea?

A

Small bowel - can be small amounts frequently or large amounts infrequently
Large bowel - easier to recognize - small amounts frequently

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12
Q

How is need to defecate triggered in large bowel diarrhea?

A

When colon is inflamed receptors in tissue send signal to poo over and over again (similar to cystitis) - animal feels need to defecate frequently, but there is little formed stool in colon = diarrhea
- Defecation reflex not triggered by amount of feces in colon, but by irritation of receptors in the colon

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13
Q

Appetite in small bowel vs large bowel diarrhea?

A

Small bowel - can be increased or decreased
Large bowel - normal

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14
Q

Water balance in small bowel vs large bowel diarrhea?

A

Small bowel - Water lost in diarrhea/vomit
Large bowel - usually not (absorption in small bowel)

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15
Q

Physical exam in small bowel vs large bowel diarrhea?

A

Small bowel - history key! Often unremarkable
Large bowel - also unremarkable, uncomfortable on rectal exam

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16
Q

What is the difference between primary vs secondary GI disease?

A

Primary - Structural
Secondary - Functional

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17
Q

How does secondary GI disease usually present?

A

Diarrhea usually not the primary presenting complaint (except exocrine pancreatic insufficiency)
Usually has same characteristics as small bowel disease

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18
Q

If Large bowel diarrhea is the main presenting sign, what should you think of as the cause?

A

Primary GI lesion

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19
Q

If mixed bowel diarrhea is the major clinical sign what should you think of as the cause?

A

Primary GI disease

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20
Q

Is BW usually helpful in diagnosing chronic GI disease? What can you use to help you diagnose the cause of diarrhea?

A

BW usually not helpful - No “easy” blood tests
Must rule out secondary GI disease
Fecal exam, therapeutic trials, and biopsy can all help

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21
Q

What are the causes of acute small bowel diarrhea?

A

Diet-related
Parasites
Infection (viral, bacterial)
AHDS (Acute Hemorrhagic Diarrhea Syndrome)

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22
Q

What are the causes of chronic small bowel diarrhea?

A

Toxins
Parasites
Diet-related
Bacteria/Protozoa
Deep Mycoses (fungal disease)
Dietary hypersensitivity
Neoplastic
Lymphangiectasia
Brush border enzyme biochemical defects
IBD

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23
Q

Give examples of the following causes of acute small bowel diarrhea:
- Diet-related
- Parasites
- Protozoa
- Viral
- Bacterial

24
Q

Give examples of the following causes of chronic small bowel diarrhea:
- Parasites
- Diet-related
- Bacteria
- Protozoa
- Fungal disease

25
What is AHDS? What is another name for this syndrome?
Acute hemorrhagic diarrhea syndrome Hemorrhagic Gastroenteritis (HGE)
26
How fast is the onset of clinical signs in HGE? What are the clinical signs?
Acute onset of vomiting and bloody diarrhea
27
How does PCV and plasma protein change in AHDS/HGE?
Significant hemo-concentration (increased PCV) with normal or low plasma protein
28
What are the breed predispositions for AHDS/HGE?
- Typically described in small breed dogs but any size/breed can be affected
29
What is the cause of AHDS/HGE?
Cause may be necrotizing toxin produced by Clostridia perfringens Type A
30
Do antimicrobials help in the treatment of AHDS/HGE?
antimicrobial therapy does not improve outcome unless the patient is septic
31
What macronutrient causes dietary hypersensitivity that leads to chronic small bowel diarrhea
PROTEIN - Dog - beef, lamb, chicken, wheat (gluten) - Cat - fish, milk, dairy
32
What clinical signs does dietary sensitivity cause? Where are the skin signs typically seen in dogs vs cats?
Chronic intermittent diarrhea, vomiting, pruritis - Cat (ears, face) - Dog (axillary region, feet)
33
Which neoplasias cause chronic small bowel diarrhea?
Diffuse lymphosarcoma Adenocarcinoma Mstocytoma (and others)
34
What is lymphangiectasia?
Pathological dilation of lymph vessels Rare disorder that causes loss of special proteins from intestines
35
What is the NEW name for IBD?
Chronic Enteropathy (CE)
36
What are the 4 types of chronic enteropathy? Which is probably the "real" IBD?
Diet Responsive CE Abx Responsive CE Immunosuppressive responsive CE (probably real IBD) Non-responsive CE
37
What is the etiology of antibiotic responsive CE?
- Abnormal/unbalanced bacterial population - Abnormal gut reaction to normal bacterial population - Combination of both
38
Does detection of gut inflammation indicate IBD that NEEDS immunosuppressive therapy? What should you try first?
No - A good proportion of patients will respond to dietary change - A small number to antibiotics - A small number need immunosuppressive therapy
39
What are the factors which contribute to chronic enteropathy?
40
What are the requirements of CE Diet treatment trials?
Dietary trial must be novel protein or hydrolyzed - If one doesn’t work, try another!
41
What are the secondary GI causes of chronic small bowel diarrhea?
Hypoadrenocorticism Hyperthyroidism Exocrine pancreatic insufficiency (EPI) Chronic pancreatitis Liver disease
42
Which secondary condition typically has no other clinical signs besides diarrhea?
Exocrine pancreatic insufficiency
43
What is protein losing enteropathy?
Syndrome rather than a specific disease Occurs when diffuse SI disease results in excessive loss of serum proteins into the gut causing hypoproteinemia
44
What are the main causes of protein losing enteropathy?
Immunosuppressive-responsive or non-responsive chronic enteropathy (IBD) Lymphangiectasia Lymphoma
45
What are the most common clinical signs associated with PLE?
GI signs (vomiting, diarrhea) Weight loss Effects of hypoproteinemia (ascites, effusion, peripheral edema)
46
Which parasites are responsible for causing large bowel diarrhea?
Truchuris vulpis (dogs) Ancylostoma caninum
47
Which protozoa are responsible for causing large bowel diarrhea?
Giardia Entamoeba Tritrichomonas fetus (cats)
48
Which bacteria are typically responsible for causing large bowel diarrhea? Which of these are zoonotic?
Campylobacter (zoonotic) Clostridium Salmonella (zoonotic) Granulomatous colitis (E. coli)
49
What are some diet-related reasons an animal would develop large bowel diarrhea?
Toxicity (garbage, etc) Fiber responsive Dietary hypersensitivity and intolerance
50
What are some inflammatory causes of large bowel diarrhea?
Idiopathic Eosinophilic Granulomatous
51
How does STRESS cause large bowel diarrhea?
Can cause changes in gut microbiome
52
What is mixed bowel diarrhea?
Mixture of small intestinal and large intestinal diarrhea signs
53
What are the most common causes of mixed bowel diarrhea?
- Giardia, Campylobacter, Tritrichomonas fetus (cats) - Dietary indiscretion/intolerance/hypersensitivity - Acute hemorrhagic diarrhea syndrome (AHDS/HGE) - Inflammatory
54
What are the best diagnostic tools for diagnosing EPI as a cause for small bowel diarrhea?
Serum Trypsin-like Immunoreactivity TLI
55
If B12 and Folate are low at diagnosis, what does this indicate for a patient with IBD?
May be a poor prognostic marker
56
What should you do before considering biopsy in cases with small bowel diarrhea?
Rule out secondary GI disease
57
What are the aims of diagnostic approach for chronic diarrhea?
Aim to go from least invasive/expensive to most invasive/expensive Consider dietary trial, only changing one element at a time so you know what worked Treat for parasites Only try abx as last resort