Long Term Conditions Flashcards

(56 cards)

1
Q

Define diabetes mellitus

A

Metabolic disorder group

Persistent hyperglycemia is caused by deficient insulin secretion =/- resistance to insulin

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2
Q

Define type 1 diabetes

A

Absolute insulin deficiency causes persistent hyperglycaemia

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3
Q

Define type 2 diabetes

A

Insulin resistance and a relative insulin deficiency result in persistent hyperglycaemia

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4
Q

Define gestational diabetes

A

Hyperglycaemia develops during pregnancy

- usually resolves after delivery

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5
Q

Causes of type 1 diabetes

A

Destruction of beta-cells in pancreatic islets of Langerhans

- autoimmunity

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6
Q

Complications of type 1 diabetes

A
Microvascular
- nephropathy
- retinopathy
- chronic painful neuropathy
- autonomic neuropathy
Macrovascular
- CVD
Metabolic
- DKA
- dyslipidaemia
Increased risk for other autoimmune conditions
Reduced QoL
Skin complications
Infections
Reduced life expectancy
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7
Q

Presentation of type 1 diabetes

A
Ketosis
Rapid weight loss
Under 50 years
BMI below 25
Personal/FH of autoimmune disease
Random plasma glucose over 11
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8
Q

Precipitating factors of DKA

A
Infection
Physiological stress
Inadequate insulin or non-adherence
Drugs
- corticosteroids
- diuretics
- salbutamol
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9
Q

Presentation of DKA

A
Increased thirst and urinary frequency
Weight loss
Inability to tolerate fluids
Persistent vomiting +/-diarrhoea
Abdominal pain
Lethargy/confusion
Fruity smell of acetone on breath
Acidotic breathing - deep sighing respiration
Dehydration
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10
Q

Treatment targets for type 1 diabetics

A

HbA1c at 48 mmol/mol (6.5%) or lower
Advise routine self-monitoring of blood glucose
- fasting 5-7 mmol/L
- random of 4-9 mmol/L

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11
Q

Causes of type 2 diabetes

A

Insulin resistance/insensitivity and insulin deficiency

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12
Q

Risk factors for type 2 diabetes

A

Obesity and inactivity
FH
Ethnicity - Asian, African and Black communities at greater risk
History of gestational diabetes
Poor dietary habits - low fibre, high GI diet
Drug treatments - statins, corticosteriods
PCOS
Metabolic syndrome
Low birth weight for gestational age

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13
Q

Complications of type 2 diabetes

A
Macrovascular
- CVD
Microvascular
- nephropathy
- retinopathy
- chronic painful neuropathy
- autonomic neuropathy
Metabolic
- dyslipidaemia
Psychological
Reduced QoL
Infections
Reduced life expectancy
Dementia
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14
Q

Drug management of type 2 diabetes

A
Metformin
- gradually increase dose over several weeks to reduce GI side effects
- monitor renal function
If metformin contrindicated or not-tolerated
- gliptin
- pioglitazone
- sulfonylurea
- SLGT-2i
Statin - reduce CVS risk
ACEi/ARB if hypertensive
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15
Q

Lifestyle management of type 2 diabetes

A
Emphasise importance of healthy balanced diet
- high fibre
- low GI index
- low-fat dairy 
- oily fish
Regular exercise - lowers blood glucose levels
- reduced CVS risk
- help with weight management
Max 14 units alcohol a week
- may exacerbate hypoglycaemic effects of drugs
Smoking
- CVS risk
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16
Q

Risk factors for diabetic foot

A
Neuropathy
Limb ischaemia
Ulceration
Callus formation
Infection/inflammation
Deformity
Gangrene
Charcot arthropathy
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17
Q

Define COPD

A

Chronic Obstructive Pulmonary Disease

  • emphysema = loss of parenchymal lung texture
  • chronic bronchitis = cough and sputum production for at least 3 months for 2 consecutive years
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18
Q

Risk factors for COPD

A
Tobacco smoking
Occupational exposure
- dusts - coal, grains, silica
- fumes or chemicals - welding fume, dyes
Air pollution
Genetics
- alpha1-antitrypsin deficiency
Lung development
- maternal smoking
- pre-term birth
Asthma
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19
Q

Complications of COPD

A
Reduced QoL 
Increased morbidity and mortality
Depression and anxiety
Cor pulmonale
Frequent chest infections
Secondary polycythaemia - overproduction of RBCs
Respiratory failure - increased airway resistance
Pneumothorax - bulla
Lung cancer
Muscle wasting and cachexia
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20
Q

Clinical presentation of COPD

A

Breathlessness - persistent, progressive over time, worse on exertion
Chronic/recurrent cough
Regular sputum production
Frequent lower respiratory tract infections
Wheeze
Cyanosis
Raised JVP
Cachexia
Hyperinflation of chest
Use of accessory muscles/pursed lip breathing

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21
Q

Features of spirometry of COPD

A

Post bronchodilator FEV1/FVC less than 0.7

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22
Q

Clinical features of cor pulmonale

A
Peripheral oedema
Raised JVP
Systolic parasternal heave
Loud pulmonary second heart sound
Hepatomegaly
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23
Q

Investigations for COPD

A

Chest x-ray
Full blood count - anaemia, polycythaemia
Spirometry

24
Q

MRC dyspnoea scale

A

1 - not troubled by breathlessness except during strenuous exercise
2 - short of breath when hurrying or walking up slight hill
3 - walks slower than contemporaries on level because of breathlessness, has to stop for breath
4 - stops for breath after 100m or few mins on level
5 - too breathless to leave house

25
Differential diagnosis of COPD
``` Asthma Bronchiectasis Heart failure Lung cancer ILD Anaemia TB Cystic fibrosis Upper airway obstruction ```
26
Define acute exacerbation of COPD
Sustained worsening of person's symptoms from usual stable state - acute in onset
27
Causes of acute exacerbations of COPD
Respiratory tract infections - commonly rhinovirus Smoking Enviromental pollutants
28
Clinical presentation of acute exacerbations of COPD
Increased breathlessness Increased cough Increased sputum production and change in colour
29
Differential diagnosis of acute exacerbations of COPD
``` Pneumonia PE Pneumothorax Acute heart failure Pleural effusion Cardiac ischemia/arrhythmia Lung cancer Upper airway obstruction ```
30
Management of COPD
``` Stop smoking Pneumococcal and influenza vaccinations Pulmonary rehabilitation SABA or SAMA to increase exercise tolerance LABA or LAMA ```
31
Management of acute exacerbations of COPD
``` Increase dose or frequency of SABA Oral corticosteroids - 30mg oral prednisolone Antibiotics - amoxicillin - doxycycline - clarithromycin ```
32
Define asthma
Chronic respiratory condition associated with airway inflammation and hyper-responsiveness
33
Risk factors for asthma
``` PMH/FH of atopic disease Male sex for pre-pubertal asthma Female sex for persistence of asthma from childhood to adulthood Respiratory infections in infancy Exposure to tobacco smoke Premature birth and low birth weight Obesity Social deprivation Exposure to inhaled particles Workplace exposure ```
34
Complications of asthma
``` Death Respiratory complications - irreversible airway changes - pneumonia - pulmonary collapse - respiratory failure - pneumothorax Imparied QoL - fatigue - underperformance and time off school/work ```
35
Clinical presentation of asthma
``` Wheeze - expiratory polyphonic Cough Breathlessness Chest tightness Episodic, diurnal and triggered/exacerbated by exercise, viral infections or exposure to cold air or allergens ```
36
Spirometry of asthma
FEV1/FVC greater than 70% Bronchodilator reversibility Variable peak expiratory flow readings
37
Differential diagnosis of asthma
``` Bronchiectasis COPD Ciliary dyskinesia Cystic fibrosis Dysfunctional breathing Foreign body aspiration GORD Heart failure ILD Lung cancer Pertussis PE TB Upper airway cough syndrome Vocal cord dysfunction ```
38
Definition of complete control of asthma
``` No daytime symptoms No night-time waking No need for rescue medication No asthma attacks No limitations on exercise Normal lung function Minimal side effects from medication ```
39
Management of asthma
``` Personalised asthma plan Routine vaccinations Inhaler technique Inhaled SABA - reliever ICS - preventer LTRA ```
40
Define MI
Necrosis of section of myocardial tissue due to ischaemia
41
Risk factors for MI
``` Male sex Advancing age Socioeconomic status Geographical location - highest in scotland, lowes in england Obesity Smoking Hyopetesnion Hypercholesterolaemia DM FH ```
42
Complications of MI
``` Acute heart failure Chronic heart failure Post-infarction angina Stroke Depression Anxiety Sudden death ```
43
Secondary prevention of previous MI
``` Relevant lifestyle changes reduce risk - stop smoking - cardioprotective diet - physically active - weight loss - alcohol less than 14 units Cardiac rehabilitation programme Medications - ACEi - aspirin + clopidogrel/ticagrelor - beta-blocker - statin ```
44
Definition of hypetension
Systolic over 140 | Diastolic over 90
45
Stages of hypertension
1 - 140/90 to 159/99 2 - 160/100 to 180/120 3 - over 180/120
46
Risk factors for hypertension
``` Age Sex Ethnicity Social deprivation Lifestyle Anxiety and emotional stress ```
47
Complications of hypertension
``` HF Coronary artery disease Stroke Chronic kidney disease Peripheral arterial disease Vascular dementia ```
48
Investigations for target organ damage due to hypertension
``` Haematuria Urine albumin:creatinine ratio HbA1c Electrolytes, creatinine and eGFR 12-lead ECG Serum total cholesterol and HDL cholesterol - CVS risk ```
49
Secondary causes of hypertension
``` Renal disorders - chronic pyelonephritis - diabetic nephropathy - glomerulonephritis - PCKD - obstructive uropathy - renal cell carcinoma Vascular - coarctation of aorta - renal artery stenosis Endocrine - primary hyperaldosteronism - phaeochromocytoma - cushing's syndrome - acromegaly - hypothyroidism - hyperthyroidism Drugs - alcohol - ciclosporin - COCP - corticosteroids - erythropoietin - NSIADs ```
50
Management of hypertension
``` Lifestyle advice - diet and exercise - reduce caffeine - reduce dietary sodium - smoking cessation - reduce alcohol consumption Drug management - ACEi/ARB - CCB - over 55 or black African/Afro-Caribbean - thiazide-like diuretic ```
51
Define heart failure
Ability of heart to maintain the circulation of blood is impaired as a result of structural or functional impairment of ventricular filling or ejection
52
Classification of heart failure
``` Ejection fraction - heart failure with reduced ejection fraction (HR-REF) - heart failure with preserved ejection fraction (HR-PEF) Time course - acute - chronic Symptomatic severity - 1-4 ```
53
Causes of heart failure
``` Myocardial disease - coronary artery disease - hypertension - cardiomyopathies Valvular heart disease Pericardial disease Congestive heart disease Arrhythmias High output states - anaemia - thyrotoxicosis - phaeochromocytoma - septicaemia - liver failure - thiamine deficiency Volume overload - end-stage chronic kidney disease - nephrotic syndrome Obesity Drugs - alcohol - cocaine - NSAIDs ```
54
Complications of heart failure
``` Cardiac arrhythmias - AF - ventricular arrhythmias Depression Cachexia CKD Sexual dysfunction Sudden cardiac death ```
55
Clinical features of chronic heart failure
Breathlessness Fluid retention Fatigue, decreased exercise tolerance, increased recovery time after exercise Light headedness or history of syncope Tachycardia Laterally displaced apex beat, heart murmurs or 3rd/4th heart sounds Raised JVP Enlarged liver Tachypnoea, basal crepitations, pleural effusions
56
Management of heart failure
Relive fluid overload - loop diuretic ACEi Beta-blocker Consider statin and antiplatelet