LONG TEST

Question 1

Testing for weakened expression of the D antigen is done by:

a. Enzyme techniques, in conjunction with an IgM anti-D
b. Performance of an IAT using an IgG anti-D
c. Increasing the time for the incubation of the saline phase d. Don’t need to do it in a blood bank

Answer 1

Performance of an IAT using an IgG anti-D

Question 2

The immunogenicity of the common Rh antigens may be described from greatest to least:

a. D>C>E>c>e
b. c>D>C>E>e
c. D>c>E>e>C
d. D>c>E>C>e

Answer 2

D>c>E>C>e

Question 3

Individuals who do not have the Rh(D) factor are classified as:

a. Rh null
b. Du
c. Rh (-)
d. Rh (+)

Answer 3

Rh (-)

Question 4

A patient’s red cells are typed as follows: Anti-D=4+; Anti-C=0; Anti-E=0 Which of the following genotypes would correspond to these results?

a. R2r
b. R1R2
c. R1r
d. R0R0

Answer 4

R0R0

Question 5

These are solutions used to increase the degree of sensitization at 37 C incubation phase:

a. Enhancement media
b. Potentiators
c. Either A or B
d. Neither A nor B

Answer 5

Either A or B

Question 6

Which of the following genotype may demonstrate position effect.

a. DcE/DCE
b. DCE/DcE
c. Dce/Dce
d. DCe/Dce

Answer 6

DcE/DCE

Question 7

Which of the following indicates for the absence of an antigen:

a. C
b. c
c. d
d. E
e. e

Answer 7

d

Question 8

Maternal IgG antibody can remain in the circulation of the newborn and continually destroy the RBCs for how long?

a. 6 days
b. 24 hours
c. 7 days
d. 25 days

Answer 8

25 days

Question 9

Rh HDFN demonstrates what type of hemolysis?

a. Intravascular hemolysis
b. Extravascular hemolysis
c. Either a or b
d. Neither a nor b

Answer 9

Intravascular hemolysis

Question 10

Antibody considered as the most clinically significant next to Rh antibodies.

a. Anti Jka
b. Anti I
c. Anti-Kell
d. Anti-i

Answer 10

Anti-Kell

Question 11

Which of the following IgG subclass can severely cause HDFN?

a. IgG1
b. IgG2
c. IgG3
d. IgG4
e. Both A and C
f. Both A and B

Answer 11

Both A and C

Question 12

Rh null individuals would demonstrate depression of the following antigens, EXCEPT:

a. Ss
b. MN
c. U
d. All of the above
e. None of the above

Answer 12

All of the above

Question 13

Which of the following Theories is not accepted in the Rh blood group:

a. Wiener
b. Fisher-Race
c. Molecular studies
d. A and B
e. B and C

Answer 13

Molecular studies

Question 14

Which of the following condition cannot be transfused with Rh positive blood:

a. C in trans to RHD
b. Del
c. Partial D
d. Weak D

Answer 14

Partial D

Question 15

f antigen is present if these compound antigens are also present:

a. CE
b. Ce
c. ce
d. rhi
e. None of the above

Answer 15

ce

Question 16

Convert Dce/DCE to rosenfield:

a. Rh:1, 2,3,4,5
b. Rh:1,2,-3,4,5
c. Rh:1,2,3,-4,5
d. Rh:1,-2,-3,4,5

Answer 16

Rh:1, 2,3,4,5

Question 17

Which of the following cases will demonstrate HDFN:

a. Rh (-) mother and Rh (+) fetus
b. Rh (+) mother and Rh (-) fetus
c. Rh (+) mother and Rh (+) fetus
d. Rh (-) mother and Rh (-) fetus e. None of the above

Answer 17

Rh (-) mother and Rh (+) fetus

Question 18

Which of the following genotype of parents will give rise to an Rh negative offspring:

a. Dd, DD
b. DD, DD
c. Dd, Dd
d. Dd,dd
e. A and B
f. C and D

Answer 18

C and D

Question 19

Which of the following genes is/are responsible for the expression of D,C,E,c,e:

a. RHD
b. RHCE
c. RHAG
d. All of the above
e. None of the above

Answer 19

All of the above

Question 20

90.Which of the following RH terminologies has no genetic basis:

a. ISBT
b. Rosenfield
c. Fisher-race
d. Wiener
e. A and B
f. C and D

Answer 20

A and B

Question 21

IgG coated RBCs in vivo are destroyed by what organ?

a. Kidney
b. Spleen
c. Thymus
d. Lymph nodes

Answer 21

Spleen

Question 22

The antibody class implicated in hemolytic disease of the newborn.

a. IgM
b. IgG
c. IgD
d. IgE

Answer 22

IgG

Question 23

Which of the following instance wherein Rhogam can be introduced to a patient:

a. 28th weeks of gestation
b. 72 hours after deliver
c. A and B
d. None of the above

Answer 23

A and B

Question 24

An individual that is Rh (-) can elicit immune response by introducing D positive RBCs as little as:

a. 2 ml
b. 5ml
c. 1ml
d. .5 ml
e. None of the above

Answer 24

1 ml

Question 25

Which of the following IgG subclass can severely cause HDFN? a. IgG1 b. IgG2 c. IgG3 d. IgG4 e. Both A and C f. Both A and B

Answer 25

Both A and C

Question 26

Blood test used to measure the amount of fetal hemoglobin transferred from a fetus to a mother's bloodstream. a. Rosette test b. Kleihauer-Betke acid elution test c. Cord blood sampling d. None

Answer 26

Kleihauer-Betke acid elution test

Question 27

Test that demonstrate D positive RBC of fetus, suspended in D negative suspension. a. Kleihauer-Betke test b. Rosette test c. Rh typing d. Weak D testing

Answer 27

Rosette test

Question 28

A 36 year old woman is pregnant for the second time and prenatal testing shows the following result Rh(-), blood type A, IAT(-). Husband tested as Rh (-). a. Candidate for RhIg b. No need for RhIg c. Low dose of RhIg should be given d. Either A or B

Answer 28

No need for RhIg

Question 29

In Kleihauer-Betke acid elution test, 50 fetal cells are counted in _____ adult cells. a. 1,500 b. 200 c. 2000 d. 20

Answer 29

2000

Question 30

Effect of having a bilirubin level of 18-20 mg/dL will lead to what specific condition in a fetus: a. Hepatosplenomegaly b. Kernicterus c. Splenomegaly d. None of the above

Answer 30

Kernicterus