Lower Gastrointestinal Surgery Flashcards

1
Q

What causes an enterocutaneous fistula?

A

An enterocutaneous fistula is an abnormal communication between the bowel and the skin, that is often accompanied by intra-abdominal abcesses. Most cases develop after surgery for imflammatory bowel disease, cancer, or lysis of adhesions. These complications usually occur in patients who are poorly prepared, who have had radiation therapy, in emergency surgery, or because of poor surgical judgement. Anastomotic breakdown, sepsis, and traumatic enterotomy (incision into bowel) are common predisposing procedures. Less commonly, enterocutaneous fistulas occur as part of the disease process in Crohn’s disease or diverticulitis. They often develop in patients who have done poorly for 4-6 days post-op. There is fever, persistant ileus, development of abcesses, dehydration, aneamia, malnourishment, and leakage of intestinal contents from the wound.

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2
Q

What are the main complications of enterocutaneous fistulas?

A
  • Electrolyte disturbances
  • Malnutrition
  • Severe Sepsis (anastomotic leaks, abcesses, and cutaneous sepsis caused by irritation of enteric effluent)
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3
Q

How do you classify enterocutaneous fistulas?

A

Low Output: less than 200mL per 24 hours
Moderate Output: between 200-500mL per 24 hours
High Output: greater than 500mL per 24 hours
Moderate or high output fistulas are usually related to the small bowel. Higher output fistulas are more prone to electrolyte imbalance and malnutrition.

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4
Q

How do you manage an enterocutaneous fistula?

A
  • Provide Bowel Rest. Consider enteral and parenteral nutrition
  • Carefully monitor fluid output from the fistula
  • Carefully monitor and manage electrolytes.
  • Somatostatin (Octreotide) to reduce fistula output
  • H2 antagonists may prevent bleeding from gastric stress ulceration
  • Skin care management via a enterostomal nurse
  • Control of sepsis (tx with broad spectrum gram negative and anearobe cover if indicated)
  • Ambulation/TEDs/subcut heparin.
  • CT scan to detect abcesses
  • Sinography
  • Contrast small bowel follw through, or contrast enema to investigate for any distal obstruction.
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5
Q

What factos help predict whether or not an enterocutaneous fistula is likely to close?

A
  • Ileal and gastric fistulas are less likely to close than lateral oesophageal, lateral duodenal, and jejunal fistulas, or pancreatic and biliary fistulas.
  • High output worse than low output
  • Worse with IBD, radiation, malignancy
  • Loss of intestinal continuity
  • Persistant intestinal obstruction distal to the fistula
  • Large adjacent abcess cavity
  • Presence of a foreign body (eg. sutures, gauze, or prothesis)
  • Epithelialisation of fistula
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6
Q

What are the anatomic features associated with rectoal prolapse?

A

Anatomic features associated with rectal prolapse include:
-deep peritoneal cul-de-sac
-a long mesorectum and poor posterior fixation of the rectum
-a redundant rectosigmoid
-a lax and atonic levator ani
In some cases functional disturbances result from chronic and prolonged straining against a pelvic floor that does not relax concomitantly. The pelvic muscles become stretched, the perineum descends stretching over the pudendal nerve. Pudendal neuropathy leads to further deenervation of anal sphincters and puborectalis. In 50% of patients, feacal incontinence occurs due to progressive deenvervation of the internal and external anal sphincters.

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7
Q

What is an occult rectal prolapse?

A

An occult rectal prolapse is caused by intersussception of the full thickness of the rectum, which does not protrude through the anal canal and may represent an early stage of complete prolapse.

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8
Q

What is a mucosal rectal prolapse?

A

A mucosal rectal prolapse is a protrusion of the rectal mucosa through the anal canal, and may be circumferential.

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9
Q

What is a complete rectal prolapse?

A

A complete rectal prolapse (proincidentia) is defined as a full-thickness rectal protrusion through the anal orifice.

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10
Q

What is the typical presentation of a rectal prolapse?

A

-Prolapsing anorectal lump, which may occur only at defeacation or may occur with coughing or walking or even spontaneously.
-Rectal Bleeding
-Mucous discharge
-Tenesmus
Associated feacal incontinence (50%), constipation causing straining, concomitant uterine prolapse or cystoceale, solitary rectal ulcer syndrome.

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11
Q

How do you differentiate between rectal prolapse and rectal heameorrhoids?

A

Rectal prolapse can be difficult to distinguish from extensive prolapsing heamorrhoids. With rectal prolapse, concentric rings of mucosa line the prolapsed tissue, and a sulcus is present between the anal canal and the rectum. Two layers of the rectal wall are palpated. Heamorrhoids are seperated by radial grooves and the sulcus is absent.

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12
Q

How do you treat rectal prolapse?`

A

Conservative management is generally prescribed for occult or mucosal rectal prolapse.
Elastic band ligation of the prolapsing anterior rectal mucosa can be helpful.
Those with persistant or unacceptable symptoms are treated surgically.

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13
Q

What are the main types of intestinal stomas?

A
  • Ileostomies: end, loop. loop-end
  • Colostomies; end, loop
  • Ceacostomy
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14
Q

What is an end Ileostomy?

A

An end ileostomy is usually formed from the end of the terminal ileum. The end ileostomy can be revesible or permanent. It can be temporary when done inc onjunction with a subtotal abdominal colectomy for toxic colitis, left sided large bowel obstruction, or ischeamic bowel. The terminal ileum is drawn through an elliptical incision in the right lower quadrant, and a muscle splitting incision in the rectus muscle. A full thickness eversion of the bowel is then performed to obtain primary Brooke-Type maturation between the distal edge of the ileum and the dermis of the skin.

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15
Q

What is a proctocolectomy?

A

A proctocolectomy is the surgical removal of the rectum, and all or part of the colon. It can be used for Crohn’s disease of familial adenomatous polyposis. It used to result in a permanent end Ileostomy. However, there are now sphincter-saving procedures, such as a restorative proctocolectomy, that are used instead.

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16
Q

What is a loop ileostomy?

A

A loop Ileostomy is used temporarily to protect a distal anastomosis such as an ileal pouch-anal anastomosis or low colorectal anastomosis, or to divert stool from the distal anorectum such as for perianal Crohn’s disease, fungating anorectal cancer, severe perineal trauma or sepsis, and feacal incontinence. It is formed using a loop of the distal ileum delivered through the abdominal wall , usually in the right lower quadrant as for end ileostomy. A supporting rod is usually inserted through the mesentery under the apex of the ileal loop to releive tension. The afferent loop will be the larger of the two stomas. The afferent loop allows passage of stool output and the efferent loop allows passage of flatus and mucous discharge from the distal defunctioned portion of the bowel.

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17
Q

How do you manage an ileostomy?

A

Normal colour ranges from pink to deep red. Intestinal peristalsis usually recommences 2-5 days post surgery. Sometimes there is an early output of watery fluid (bowel sweat) before the return of bowel function. Oral feeding should be deferred until paralytic ileus has stopped. the rod of a loop ileostomy is removed 4-5 days post surgery.
As oedema subsides, the stoma is remeasured for new appliances about 4 weeks after construction. Ostomates should avoid nuts, popcorn, string vegetables, cabbage, oranges, or fruit peels.

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18
Q

What is the normal output for an ileostomy?

A

The normal ileostomy output ranges from 500mL-1000mL, higher outputs may result in dehydration, low output may indicate obstruction. A partial bowel obstruction may be associated with a high output of watery intestinal content.

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19
Q

What are the common comlications of an ileostomy?

A

Ischeamia, mucocutaneous seperation, parastomal abcess, fistula, bleeding, high output, ileostomy retraction, parastomal hernia or prolapse,small bowel obstruction, parastomal ulcer, skin irritation, ileostomy stricture.

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20
Q

What is an end sigmoid colostomy?

A

An end sigmoid colostomy may be temporary or permanent. The end stoma is permanent following an abdominoperineal resection of the rectum for malignant disease or for severe feacal incontinence not appropriate for a perineal repair. It may serve as a temporary stoma for feacal diversion in radiation proctitis, or following a Hartmann’s procedure for resection of the rectosigmoid with benign or malignant disease. The colostomy effluent is usually solid and non irritating as it has travelled through the colon. Thus is can be made flush with the skin without a spout.

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21
Q

What is a loop colostomy?

A

A loop colostomy may be constructed using a loop of the transverse or sigmoid colon. It serves as a temporary feacal diversion following a low colorectal anastomoses or for obstruction, inflammation, trauma, or perineal wounds. The loop may be brought through either the lower quadrant or the right upper quadrant. Whilst most loop colostomies are fully diverting in the first few months after construction, feacal diversion becomes incomplete in 20% of patients because of recession of the stoma.

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22
Q

What is a ceacostomy?

A

A tube ceacostomy using a No. 30 Fr Foley catheter is usually performed rather than a primary stoma. It is done for either colonic decompression or ceacal volvulus. The tube can be removed after 7-10 days and the ceacutaneous fistula should close spontaneously in the absence of a distal obstruction. However, a ceacostomy is not fully diverting and it is difficult to manage becuase of dislodgement or blackage of the tube. This procedure is rarely performed.

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23
Q

How do you manage a colostomy?

A
  • Preoperative stoma siting and counselling
  • Ileus 2-3 days post surgery
  • Unlike an ileostomy (where you wait for passage of gas and effluent), colostomies need stimulation by ingestion of food before it begins to function.
  • Ischeamia more common in colostomy
  • Bulking agents
  • Some patients may choose to undertake daily colostomy irrigations.
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24
Q

What are the complications of a colostomy?

A

Complications associated with a colostomy are similar to those associated with ileostomy but they differ in frequency. Parasternal hernias and stoma prolapse are more common. Strictures also occur more frequently. Food bolus obstruction and skin irritation are less common.

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25
Q

What is an anal fissure?

A

An anal fissure is a linear tear or superficial ulcer of the anal canal, extending from just below the dentate line to the anal margin. It usually occurs midline posteriorly, or sometimes anteriorly in females, particularly after a pregnancy. It presents with severe anal pain during and immediately after defecation and anal outlet bleeding. The pain is so intense that the patient avoids opening their bowels. The pain has been attributed to the spasm of the internal anal sphincter.

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26
Q

On inspection, what sign suggests that an anal fissure is chronic?

A

A chronic anal fissure will be associated with a sentinel skin tag at the anal margin, and a hypertrophied anal papilla at the upper end of the anal canal.

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27
Q

What is the differential diagnosis for anal fissures?

A

Differential diagnosis of anal fissures includes fissures due to Crohn’s disease, and neoplastic fissure. Fissures due to Crohn’s disease are usually not in the midline. They are deep, with indolent edges, tend to be multiple, painfree, and occur at atypical sites. Neoplastic ulcers are usually due to squamous cell carcinoma. The ulcer is deep and has heaped up edges. Also consider syphilis and HIV.

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28
Q

How do you treat anal fissures?

A

Conservative: apply topical anaesthetic and hydrocortisone ointment. High fibre diet to increase stool bulk (so the stool itself dilates the sphincter). 50% healed after 4 weeks. High recurrence rate. Glycerine trinitrate paste can be used to relax the internal sphincter.
Surgical: Lateral internal anal sphincterotomy; the distal internal sphincter is divided under anaesthesia. The large sentinel skin tag and hypertrophied anal papilla are excised. Recurence is <3%. Problems controlling flatus in 10%.

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29
Q

What is a Perianal abscess?

A

Perianal abscess is a common condition that is usually due to a blocked anal gland that subsequently becomes infected (cryptoglandular origin). There are usually no predisposing factors, but patients with diabetes, Crohn’s or are immunocomprimised are susceptible. The abcess may discharge spontaneously to the skin, and if communication to the skin is established then a fistula may result in up to 50% of patients. Patients present with throbbing pain, localised swelling, tenderness, and redness. May also have signs of fever and sepsis.

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30
Q

How do you treat perianal abscesses?

A

Incise and drain the abscess under local anaesthesia. Use antibiotics if the sepsis is extensive or if the patient is immunocompromised. If it usual to leave a small drain or packing gauze in the abscess cavity for a few days post operatively. A sigmoidoscopy should also be done of the rectal mucosa.

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31
Q

What is a fistula-in-ano?

A

A fistula is a communication between any two epithelial lined surfaces. A fistula-in-ano implies a direct communication between the anorectum and the perineal skin. The patient may present with recurrent perianal abscesses or with a bloody and purulent discharge. Pain and discomfort are usual. The external opening is usually visible on examination.

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32
Q

What is Goodall’s law?

A

Goodsall’s law indicates that fistulas with an anterior external opening drain directly into the anus at the dentate line, and those with a posterior external opening take a curved course to enter the anal canal in the midline. While the majority of fistulas probably conform to Goodsall’s law, there are some exceptions.

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33
Q

How do you treat fistula-in-ano?

A

Fistula-in-ano rarely heals spontaneously. Low Fistula: identify internal and external openings and ‘lay open’ the intervening track by fistulotomy (allowing the tract to heal by secondary intention).
High fistula: A fistulotomy may be contraindicated if there the internal opening is above the levator mechanism. In this patients, fistulotomy would include division of the levator, which would result in incontinence. Insert a seton in between the two openings, and it may act as a drain whilst being progressively tightened so that the tissue can heal.
For very complex fistulas, a proximal stoma may be formed to divert the faecal stream, in addition to other surgical manoeuvres.

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34
Q

What are the different causes of fistula-in-anos?

A

Idiopathic, anal gland infection, Crohn’s disease, iatrogenic, carcinoma, trauma (especially obstetric), foreign body (fish bone), radiation damage, tuberculosis, actinomycosis.

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35
Q

What is the typical presentation of anovaginal and rectovaginal fistulas?

A

The patient passes flatus or feaces via the vagina. Most commonly caused by obstetric trauma. Diagnosis made via examination under anaesthesia.

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36
Q

What are the most common types of anal cancers?

A

Most anal cancers are malignant epithelial tumours of the anal canal. The majority are squamous cell carcinomas (SCCs). HPV is a risk factor for anal cancer.

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37
Q

What is the anal transitional zone?

A

The anal transitional zone comes fro the epithelia that lines the upper third of the anal canal. It has a variable proximal extension into the lower rectum that is age dependent (broader in the elderly). It consists of a mixture of stratified squamous epithelium, stratified columnar epithelium, and cuboidal epithelium.

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38
Q

What is the typical presentation of anal cancer?

A

Anal cancer typically presents with bleeding or symptoms of pruritis ani, such as moisture, perianal itch, a burning sensation or pain after defecation, if the tumour is ulcerated and infected. It usually presents as an ulcer with typically rolled edges. The diagnosis must always be confirmed with incisional biopsy. It generally spreads upwards, and may spread via the lymphatics. It has a tendency to present at a late stage.

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39
Q

What is a pilonoidal sinus?

A

A pilonoidal sinus is an acquired chronic inflammatory condition in which hair becomes embedded in a midline pit or track, usually between the buttocks around the coccygeal region. It affects young hirsute males. They can present asymptomatically, with an abscess, or with chronic sepsis with discharge and discomfort.

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40
Q

What is pruritis ani?

A

Patient complains of itching around the anus that is not relieved by scratching. Symptoms are worse at night. Itch leads to repeated scratching and skin trauma. Treat by excluding any obvious causes and malignancy.

41
Q

What is hidranitis suppurrativa?

A

Hidradenitis supprativa is a chronic, debilitating inflammatory condition of the apocrine glands. The axillae, groin, perineum, and perianal skin are primarily involved. Apocrine glands begin to function at puberty and their secretions are thick and foul smelling. It is thought that an increase in androgens leads to abnormal The glands then become infected. The infected glands are painful and discharge maloderous fluid.

42
Q

What are condylomata acuminata?

A

Condylomata acuminata are perianal warts. They are sexually transmitted. They are caused by HPV genotype 6. Perianal warts may undergo malignant change and become a squamous cell carcinoma. Treat with diathermy and scissor excision.

43
Q

What is levator syndrome?

A

Patients describe the onset of severe perineal pain that is self limiting, lasting from only a few minutes to less than half an hour, often after sexual activity or upon waking from sleep (proctalgia fugax). They may also present with ball like rectal pressure radiating from the rectum towards the cocyx or buttock. Occurs more frequently in anxious women. It is caused by an idiopathic self limiting painful spasm of the pelvic floor muscles.

44
Q

What are the causes of small bowel obstruction?

A

Most common: adhesions, then hernias (ventral, inguinal, femoral, internal). Also:

  • Neoplasms (malignant:primary/metastatic, benign)
  • Strictures (Crohn’s disease, ischeamia)
  • Radiation Enteritis
  • Intersussception
  • Volvulus
  • Gallstone ileus
  • Bezoar
  • Superior mesenteric artery syndrome
45
Q

How does a small bowel obstruction typically present?

A

A small bowel obstruction typically presents with crampy abdominal pain, nausea and vomiting, abdominal distension, and constipation. Patients with a proximal obtruction are likely to present within a day with pain and vomiting. Patients with a distal obstruction present with a 2-3 day history of crampy abdominal pain prior to vomiting, distension and constipation are prominent features. Bowel sounds are initially hyperactive and high pitched. In a dlayed presentation the bowel sounds may be reduced, indicating secondary ileus. If there is bowel ischeamia there will be constant and severe abdominal pain associated with gaurding, tachycardia, fever, and leucocytosis.

46
Q

What are your radiological findings for a small bowl obstruction?

A

Erect abdominal xray: dilated small bowel with air fluid levels, presence of colonic gas may indicate an incomplete obstruction or the presence of an adynamic ileus. May seen foreign bodies causing obstruction eg. gallstones.
NB: barium is unpopular as there is risk of inspissation of barium proximal to the obstruction and potential peritoneal contamination if perforation is present.
Gastrograffin small bowel follow through is use to establish complete vs incomplete obstruction. Gastrograffin may stimulate peristalsis and may dehydrate the patient.

47
Q

What sort of findings would you expect to see on laboratory studies in a small bowel obstruction?

A

If the small bowel obstruction has been present for long enough, it can present with a hypokaleamic, hypochloraemic metabolic alkalosis. There may be a leucocystosis if there is impending bowel ischeamia, and aneamia may indicate a malignant cause. Deranged LFT’s with hypoalbuminaemia may be associated with poor nutrition and sepsis.

48
Q

How do you treat a small bowel obstruction?

A
  • Fluid and electrolyte replacement
  • Monitor pulse, BP, tissue turgor, and urine output, central venous or pulmonary artery monitoring is considered in older patients with a history of cardiac disease.
  • NG tube to decompress the upper gastrointestinal tract
  • Prescribe analgesia with precaution so as not to mask the signs of peritoneal irritation which may indicate impending bowel ischeamia.
  • Non operative or Operative managment,
49
Q

Discuss operative versus non-operative treatment of an obstruction of the small bowel.

A

Non operative treatment (resuscitation, decompression, and monitoring) can be used for small bowel obstructions. If there is any sign of intestinal strangulation or if there has been no significant improvement for 48 hours, then surgery is indicated (nb: constant rather than intermittant pain suggests bowel ischeamia). In surgery, the junction between the collapsed and dilated areas of bowel is found. If the bowel is not viable, a simple resection and primary anastomoses is formed. Alternatively, a side-to-side bypass may be used.

50
Q

What is Ogilvie’s Syndrome?

A

Ogilvie’s Syndrome is a pseudo-obstruction where there is acute dilatation of the colon. It presents with the same clinical features as an organic obstruction with the same potential complications, but is usually associated with some other illness. Treat with repeated DRE and sigmoidoscopes. If not, give neostigmine . If this doesn’t work, move onto colonoscopic decompression.

51
Q

What are the typical features of a large bowel obstruction?

A

A large bowel obstruction typically presents with:
-Abdominal pain due to distension and colic
-Abdominal distension due to retention of feaces and flatus
-Constipation (if its a complete obstruction this will be absolute - no passage of flatus)
-Gaurding/Peritonism if perforation has occured
-Vomiting can be a late symptom.
-High pitched bowel sougnds and abdomen highly tympanic to percussion.
-DRE may shows bleeding or mass of carcinoma
Occurs in the elderly

52
Q

What are the causes of large bowel obstructions?

A
  • Carcinoma of the colon or rectum (at least 50% of bowel obstructions), occurs at the sigmoid colon and the splenic flexure
    -Sigmoid volvulus
    -Diverticular disease
    Less common causes include: strictures from IBD, ischemic and radiation strictures, intussusceptions, adhesions (much more likely to cause a small bowel obstruction), and feacal impaction.
53
Q

How do you investigate a large bowel obstruction?

A

A plain abdominal x ray will reveal the typical features of a sigmoid volvulus, with a distended colon in the right upper quadrant. Free intraperitoneal gas indicates colonic perforation.
A water soluble contrast enema should be used to define the level of the obstruction, and the nature of the obstructing lesion.

54
Q

How do you manage a large bowel obstruction?

A

Large bowel obstruction is managed surgically. If it is caused by a volvulus(rigid sigmoidoscope or colonoscope), then it can be managed by endoscopic decompression. If not, it is treated surgically in a three stage surgical management. Fist stage: establish a proximal colostomy. Within weeks folow with the second stage involving resection and anastomosis. Finally, close the colostomy weeks later.
Colorectal stenting can be used as a definitive palliative treatment for obstruction resulting from cancer.

55
Q

Discuss the blood supply to the bowel.

A

The intestinal tract has a generous overlapping blood supply. The three main vessels supplying the bowel include the cealiac axis, the superior mesenteric artery, and the inferior mesenteric artery. There are also important collaterals from the hypogastric vessels. The CA communicates with the SMA via the pancreaticoduodenal loop, and to a lesser extent, the dorsal pancreatic artery. The SMA communicates with the IMA via themarginal artery. In general, acute occlusion of any of the three main mesenteric vessels may lead to acute bowel infarct. However, gradual occlusion will lead to the creation of collaterals and will not cause injury.

56
Q

What are the causes of non-occlusive intestinal ischeamia?

A

Non occlusive intestinal ischeamia is caused from inadequate perfusion secondary to hypotension, spasm, or intestinal distension.

57
Q

What are the causes of occlusive intestinal ischeamia?

A

Occlusive intestinal ischeamia is caused by SMA embolism, thrombus, and venous thrombosis. Mesenteric embolus is uncommon.

58
Q

Describe the pathology of Acute Mesenteric Ischeamia?

A

In acute mesenteric ischeamia, acute intestinal ischeamia leads to intense loss of circulating blood volume and metabolic acidosis (early reversible stage). Vasoactive substances are released in response to ischeamia to further diminish perfusion. Partial reduction of molecular oxygen results in the production of oxygen free radicals. These supraoxide radicals lead to increased vascular permeability and mucosal injury. They are central to the reperfusion injury. The release of free radicals particularly occurs when the bowel is reperfused, causing the most damage upon reperfusion. Later in the process, mucosal disruption and bacterial invasion develop with endotoxin release, septiceamia and shock, indicating an irreversible injury.

59
Q

What are the radiographic changes seen in mesenteric ischeamia?

A

Early stage plain xray is normal. LAter, features of ileus develop and air is found in the portal vein and liver. The dignosis of acute limb ischeamia can be confirmed with visceral angiography of the CA, SMA, and IMA via the femoral artery. A mesenteric angiogram will pick up an occlusive obstruction. However, if the ischeamia is ‘non-occlusive’ in nature then it will not be found on imaging. Diagnosis can also be made by laparotomy.

60
Q

How do you manage mesenteric ischeamia?

A
  • IV Rehydration
  • Monitor vital signs, urine output and central venous or wedged pulmonary arterial pressure.
  • IV antibiotics and blood cultures
  • Correct metabolic acidosis
  • Heparin (prevent clot progression and counteract DIC)
  • Consider thrombolytic therapy, vasodilation, or laparotomy
61
Q

What is mesenteric venous thrombosis?

A

Mesenteric venous thrombosis is a less common cause of mesenteric infarction. Causes: idiopathic, portak hypertension, heamatological diseases, malignancy, inflamatory bowel diseases, Presentation is insidious in onset and presents with vague abdominal discomfort, distension, altered bowel habits, and nausea. Later will develop features of acute abdomen such as tenderness, gaurding and leucocytosis. X ray usually features an ileus with dilated air loops of small bowel and air fluid levels. Angiography is less useful. Diagnostic peritoneal lavage may reveal serosagnuinous fluid.

62
Q

What is the consequence of resection of the ileum so that there is less then 100cm of ileum?

A

The ileum is responsible for reabsorbing bile salts. With less than 100cm of ileum, the enterohepatic circulation of bile salts in impairedleading to fat malabsorption and steathorrea. This, in turn, leads to malabsorption of fat soluble vitamins A, D, E, and K. The ileum is also the site for absoprtion of intrinsic factor bound vitmain B12.

63
Q

What is chronic mesenteric vascular disease and how do it present?

A

Chronic mesenteric vascular disease is poorly defined and poorly understood. High grade arterial stenosis may be present with a poor correlation to symptoms of ischeamia. Presents with weight loss, malabsorption and post prandial pain that occurs soon after a meal and may last several hours.

64
Q

What are the two regions of the bowel that are anatomically susceptible to gut ischeamia?

A
  • Griffith’s Point: occurs at the splenic flexure between the SMA and IMA.
  • Sudeck’s Critical Point: occurs midway through the sigmoid colon between the IME and the hypogastric vessels.
65
Q

What are the phases of ischeamic colitis?

A

1) Transient Ischeamia: Reversible inflammation of the mucosa and submucosa. ‘Thumb printing’ of bowel lumen seen on radiograph.
2) Ischeamic Stricture; Partial thickness injury to the mucosa and muscular layers of the bowel leading to delayed presentation with fibrosis and strictures.
3) Gangrene: due to full thickness necrosis and infarction. Perforation, sepsis and death ensure.

66
Q

What is the typical presentation of ischeamic colitis?

A

Ischeamiccolitis can present with left iliac fossa pain, bloody diarrhoea, fever, and abdominal distension. The patient is usually not grossly ill or shocked.

67
Q

What is the typical clinical features of appendicitis?

A

Abod pain: periumbilical, progresses to the right iliac fossa. Nausea, vomiting, norexia. Atypical presentations can include right upper quadrant pain from a long appendix, or a right loin pain from a restroceacal appendix. Patients may have one or two loose bowel movements. Tenderness over McBurney’s Point (1/3 of the way from the ASIS and the umbilicus), board like rigidity/gaurding, Rovsing’s Sign, Psoas Sign (extension of the right leg to irritate psoas, positive in retrocecal appendicitis). Pain may also be in RUQ for pregnancy.

68
Q

In appendicitis, what causes the initial periumbilical pain? What causes the right iliac fossa pain?

A

The inital periumbilical pain is caused from obstruction and inflammation of the appendix and is mediated through visceral pain fibres as a mid-gut pain. When the appendicitis becomes transmural, the serosa of the appendix and the perietal peritoneum are involved, causing a localised pain mediated through the somatic pain fibres in the right iliac fossa.

69
Q

What are the various positions of the appendix?

A

Retroceacal, pelvic, and ileal.

70
Q

How do you investigate appendicitis?

A

Leucocytosis: 11,000 017000/mL with a neutrophilia
Urinanalysis and micropscopy (dx UTI)
Plain abdominal xrays are rarely helpful. May detect localised ileus, free intraperitoneal air, or a feacolith in the appendix area.
Ultrasound may show a thick walled appendix with a dilated lumen.
Ct scan with ingestion of oral contrast agent 80% sensitive and specific.

71
Q

What is mesenteric adenitis?

A

Mesenteric adenitis refers to an inflammation of the lymph nopdes. The process may be acute or chronic. Most common in children. Presents similar to acute appendicitis, often with a history of recent sore throat with fever.

72
Q

What is a Meckel’s Diverticulum?

A

Meckel’s Diverticulum is a congenital condition that arises from a failure of embryonic obliteration of the omphalomesenteric duct connecting the feotal gut to the yolk sac. Meckel’s diverticulum is antimesenteric, contains all layers fo the bowel wall and has its own blood supply. It is present in 2% ofthe population, and is commonly within 1m of the ileoceacal valve. In 20% of cases the mucosa contains heterotopic epithelium of gastric, colonic, or pancreatic in origin. Symptomatic cases are usually males.

73
Q

What is the typical presentation of a malignant small bowel tumour? What about a benign small bowel tumour?

A

Small bowel tumours are very rare, malignant small bowel tumours are even more rare. Small bowel tumours present with weightloss, abdominal pain, small bowel obstruction, gastrointestinal bleeding, and an abdominal mass. A benign tumour presents with abdo pain, small bowel obstruction and GI bleeding.

74
Q

What are the different types of benign small bowel tumours?

A

Leiomyomas (jejunum), Adenomas (duodenum, periampullary region), Lipomas (distal ileum). Also Peutz-Jager Syndrome.

75
Q

What are the four main type of malignant small bowel tumours?

A

There are four main types of malignant small bowel tumours: adenocarcinoma, carcinoid tumour, lymphoma, and leiomyosarcoma. There may also be metastatic tumours to the small bowel.

76
Q

What is a carcinoid tumour?

A

Carcinoid tumours arise from the enterochromaffin ells of the gastrointestinal tract. The majority of carcinoid tumours occur in the appendix. Aggressive carcinoid tumours are associated with carcinoid syndrome.

77
Q

What is carcinoid syndrome?

A

Carinoid syndrome is thought to be aused by the release of vasoactive substances into the systemic circulation, such as bradykinin, serotonin, tachykinins (substance P, neuromedin A), histamine, dopamine, and prostaglandins. Carcinoid syndrome occurs in lung, testes, and ovarian cancers, as well as GI cancers that have metastasised to the liver.

78
Q

What are the features of carcinoid syndrome?

A

Classic clinical features include diarrhoea, flushing of the face and upper trunk that lasts a few seconds to minutes, and bronchospasm; all precipitated by foods, alcohol, or emotional stress. Venous telangictasias, pellagra (diarrhoea, dementia, dermatitis), and right sided endocardial valvular fibosis may be caused by the circulating vasoactive amines. Progress to tricuspid insufficiency, pulmonary stenosis, and right sided heart failure may occur. Treat carcinoid syndrome using a somatostatin analogue (sandostatin). Chemotherapy may also be used.

79
Q

What is carcinoid crisis?

A

Carcinoid crisis is a rare, life threatening event invoving intense flishing, severe diarrhoea, cardiovascular abnormalities (tachycardia, arrythmias, hypertension, or hypotension) and central nervous system problems that range from dizziness to coma.

80
Q

What are the different types of benign small bowel tumours?

A

Leiomyomas (jejunum), Adenomas (duodenum, periampullary region), Lipomas (distal ileum). Also Peutz-Jager Syndrome.

81
Q

What are the four main type of malignant small bowel tumours?

A

There are four main types of malignant small bowel tumours: adenocarcinoma, carcinoid tumour, lymphoma, and leiomyosarcoma. There may also be metastatic tumours to the small bowel.

82
Q

What is a carcinoid tumour?

A

Carcinoid tumours arise from the enterochromaffin ells of the gastrointestinal tract. The majority of carcinoid tumours occur in the appendix. Aggressive carcinoid tumours are associated with carcinoid syndrome.

83
Q

What is carcinoid syndrome?

A

Carinoid syndrome is thought to be aused by the release of vasoactive substances into the systemic circulation, such as bradykinin, serotonin, tachykinins (substance P, neuromedin A), histamine, dopamine, and prostaglandins. Carcinoid syndrome occurs in lung, testes, and ovarian cancers, as well as GI cancers that have metastasised to the liver.

84
Q

What are the features of carcinoid syndrome?

A

Classic clinical features include diarrhoea, flushing of the face and upper trunk that lasts a few seconds to minutes, and bronchospasm; all precipitated by foods, alcohol, or emotional stress. Venous telangictasias, pellagra (diarrhoea, dementia, dermatitis), and right sided endocardial valvular fibosis may be caused by the circulating vasoactive amines. Progress to tricuspid insufficiency, pulmonary stenosis, and right sided heart failure may occur. Treat carcinoid syndrome using a somatostatin analogue (sandostatin). Chemotherapy may also be used.

85
Q

What is carcinoid crisis?

A

Carcinoid crisis is a rare, life threatening event invoving intense flishing, severe diarrhoea, cardiovascular abnormalities (tachycardia, arrythmias, hypertension, or hypotension) and central nervous system problems that range from dizziness to coma.

86
Q

What are the different types of benign small bowel tumours?

A

Leiomyomas (jejunum), Adenomas (duodenum, periampullary region), Lipomas (distal ileum). Also Peutz-Jager Syndrome.

87
Q

What are the four main type of malignant small bowel tumours?

A

There are four main types of malignant small bowel tumours: adenocarcinoma, carcinoid tumour, lymphoma, and leiomyosarcoma. There may also be metastatic tumours to the small bowel.

88
Q

What is a carcinoid tumour?

A

Carcinoid tumours arise from the enterochromaffin ells of the gastrointestinal tract. The majority of carcinoid tumours occur in the appendix. Aggressive carcinoid tumours are associated with carcinoid syndrome.

89
Q

What is carcinoid syndrome?

A

Carinoid syndrome is thought to be aused by the release of vasoactive substances into the systemic circulation, such as bradykinin, serotonin, tachykinins (substance P, neuromedin A), histamine, dopamine, and prostaglandins. Carcinoid syndrome occurs in lung, testes, and ovarian cancers, as well as GI cancers that have metastasised to the liver.

90
Q

What are the features of carcinoid syndrome?

A

Classic clinical features include diarrhoea, flushing of the face and upper trunk that lasts a few seconds to minutes, and bronchospasm; all precipitated by foods, alcohol, or emotional stress. Venous telangictasias, pellagra (diarrhoea, dementia, dermatitis), and right sided endocardial valvular fibosis may be caused by the circulating vasoactive amines. Progress to tricuspid insufficiency, pulmonary stenosis, and right sided heart failure may occur. Treat carcinoid syndrome using a somatostatin analogue (sandostatin). Chemotherapy may also be used.

91
Q

What is carcinoid crisis?

A

Carcinoid crisis is a rare, life threatening event invoving intense flishing, severe diarrhoea, cardiovascular abnormalities (tachycardia, arrythmias, hypertension, or hypotension) and central nervous system problems that range from dizziness to coma.

92
Q

What are the different types of staging of colorectal cancer?

A
UICC TNM staging, and
Modified Dukes Staging (A-C)
A: Tumour confined to bowel wall
B: Tumour invading through the serosa
C: Lymph node involvement.
93
Q

What is the typical presentation of a ceacal or right sided carcinoma?

A

The typical presentation of a ceacal or right-sided carcinoma generalyl consists of insidious onset of iron deficiency aneamia due to occult feacal blood loss. May present with distal ileal obstruction (late sign as intestinal contents is liquid at this stage). Palpable right iliac fossa mass. Lethergy or fever of unknown origin. Acute appendicitis from occlusion of the appendiceal orifice by ceacal cancer.
Right sided colonic cancer is more common in women, and tends to have a better prognosis than left sided colon cancer.

94
Q

What is the typical presentation of Left sided colon or sigmoid carinoma?

A

Left sided colon cancer presents with a change in bowel habits (constipation with periods of diarrhoea), altered blood mixed in with stools and some possible mucous, and possibly a palpable mass in the let side of the abdomen. The patient may experience lower abdominal colic, distension, and a desire to defecate.

95
Q

What is the typical presentation of rectal cancer?

A

Rectal bleeding, Changes in bowel habit (frequent bowel movements or diarrhoea), tenesmus or frequnt urge to defecate, and anal and perineal pain.

96
Q

What are the different types of staging of colorectal cancer?

A
UICC TNM staging, and
Modified Dukes Staging (A-C)
A: Tumour confined to bowel wall
B: Tumour invading through the serosa
C: Lymph node involvement.
97
Q

What is the typical presentation of a ceacal or right sided carcinoma?

A

The typical presentation of a ceacal or right-sided carcinoma generalyl consists of insidious onset of iron deficiency aneamia due to occult feacal blood loss. May present with distal ileal obstruction (late sign as intestinal contents is liquid at this stage). Palpable right iliac fossa mass. Lethergy or fever of unknown origin. Acute appendicitis from occlusion of the appendiceal orifice by ceacal cancer.
Right sided colonic cancer is more common in women, and tends to have a better prognosis than left sided colon cancer.

98
Q

What is the typical presentation of Left sided colon or sigmoid carinoma?

A

Left sided colon cancer presents with a change in bowel habits (constipation with periods of diarrhoea), altered blood mixed in with stools and some possible mucous, and possibly a palpable mass in the let side of the abdomen. The patient may experience lower abdominal colic, distension, and a desire to defecate.

99
Q

What is the typical presentation of rectal cancer?

A

Rectal bleeding, Changes in bowel habit (frequent bowel movements or diarrhoea), tenesmus or frequnt urge to defecate, and anal and perineal pain.