Lower Urinary Tract Carcinoma - Pathoma Flashcards Preview

CRRAB II Week 4 - WLB > Lower Urinary Tract Carcinoma - Pathoma > Flashcards

Flashcards in Lower Urinary Tract Carcinoma - Pathoma Deck (16):

What are the three types of cancer that can arise in the lower urinary tract?

  1. Urothelial carcinoma
  2. Squamous cell
  3. Adenocarcinoma


What is the most common type of lower urinary tract cancer?

Urothelial Carcinoma

(usually arises in the bladder)


What is Urothelial Carcinoma?

  • Malignant tumor arising from the urothelial lining of renal pelvis, ureter, bladder, or urethra
    • usually arises in the bladder


What is the #1 risk factor of Urothelial Carcinoma?

Cigarette Smoke

(particularly polycyclic aromatic hydrocarbons)


What are the other risk factors for Urothelial Carcinoma?

  • Naphthylamine
    • (carcinogen in cigarette smoke)
  • Azo dyes
  • Long term cyclophosphamide or phenacetin


What is the classic presentation of Urothelial Carcinoma?

  • Painless hematuria
    • generally seen in older adults


What are the two pathways in which Urothelial Carcinoma arises?

  • Flat
    • starts as high-grade thelilal carcinoma → flat lesions → progresses to invading tumor
    • associated with early p53 mutations
  • Papillary
    • fibrovascular core with blood vessel running through it
    • tumor starts as low grade → progresses to high grade → then invades


What does the term "Field Defect" mean?

  • Entire urothelial lining has been mutated
    • exposure to carcinogens throughout lower urinary tract over a long period of time
    • mutations present throughout, only a matter of time before multiple tumors develop
      • often have recurrence


Why is squamous cell carcinoma of the lower urinary tract interesting?

  • Lower urinary tract does not normally have any squamous cell epithelium
    • must develop squamous metaplasia
    • urothelial cells → dysplasia → squamous cell


What area of the lower urinary tract does Squamous Cell Carcinoma usually involve?



What are the three key risk factors for Squamous Cell Carcinoma?

  1. Chronic cystitis
  2. Schistosoma hematobium
  3. Long-standing nephrolithiasis


What is Schistosoma hematobium?

  • Seen in Middle East
  • Young male
  • Bug embeds in bladder wall → chronic inflammation ⇒ squamous metaplasia
    • results in squamous cell carcinoma


What is adenocarcinoma?

Malignant proliferation of glands


What does an Adenocarcinoma of the lower urinary tract arise from?

  • Urachus remnant
    • do not normally have glandular tissue in bladder
    • embryological structure that helps fetus drain waste from bladder into the yolk sac
      • lined with glandular cells → most commonly at the dome of the bladder


How is cystitis glandularis a risk factor for Adenocarcinoma?

  • Chronic inflammation of the bladder 
    • get columnar metaplasia from chronic inflammation
      • becomes adenocarcinoma


What is bladder exstrophy? How is it associated with Adenocarcinoma of the lower urinary tract?

  • Congenital failure to form caudal (lower) portion of bladder wall & abdominal wall
    • exposes surface of bladder to outside
    • increased risk for adenocarcinoma later in life