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Flashcards in Lumps and Bumps Deck (23):
1

What is botryomycosis?

NOT fungal!
- also called bacterial granuloma, staphylococcal pseudomycetoma
-> nodules and non-healing wounds

2

What are nodular lesions usually caused by?

- cutaneous neoplasia
- inflammatory process (diffuse or nodular inflam pattern, or panniculitis) usually granulomatous (may be sterile [FB] but usually infection [bacteria/mycobacteria/viral/funghi/parasites])
- trauma
- depositional disease eg. amyloidosis

3

Diagnositcs for nodular lesions? Exception?

- histology (biopsy)
- cytology (FNA)
- macerated tissue culture
> exception sarcoids where invasive procedures may stimulate further invasion

4

What is panniculitis?

- inflam subcutaneous fat and connective tissue
-usually infective

5

Which neoplasia affects the interfollicular epithelium?

- papilloma
- squamous cell carcinoma

6

What 4 main sites give rise to skin neoplasia?

- epithelium
- mesenchyme
- round cells (MCT, histiocytes, lymphocytes)
- mets

7

What may appear like a nodule in horses but isnt?

wheals/hives - will be oedematous (pitting)

8

3 most common skin neoplasia in dogs and cats?

> dogs
- hepatoid gland adenoma (perianal, testosterone dependant)
- sebaceous adenoma
- trichoepithelioma
> cats
- basal cell tumour
- SCC
- aprocrine duct/gland/ceruminous gland adenoma

9

What type of neoplasm will regress on its own?

Histiocytoma

10

What may epithelial cells in the skin be 'destined' to become?

- basal keratinocytes -> squames
- inner and out root sheaths of follicle
- adnexal glands and ducts

11

Are majority of epithelial tumours malignant?

No - mostly benign

12

3 tumours of the epidermis

- papilloma (warty, young dogs)
- inverted papilloma
- SCC (white cats face tips, keratin pearls/swirls on histo)

13

What types of tumour show adnexal differentiation?

- hair follicle
- sebaceous (+ modified sebaceous) glands
- sweat (+ modified) glands

14

5 hair follicle tumours

- infundibular keratinising acanthoma
- tricholemmoma
- trichoblastoma (=basal cell tumour)
- trichoepithilioma
- pilomatricoma

15

3 tumours of sebaceous glands/modified sebaceous glands?

- sebacious hyperplasia/adenoma/epithelioma/adenocarcinoma
- hepatoid gland adenoma/adenocarcinoma
- meibomian gland adenoma/epithelioma/adenocarcinoma

16

4 tumours of sweat glands/modified?

- apocrine gland adenoma/ductal adenoma/adenocarcinoma
- eccrine (atrichial) adenoma/adenocarcinoma
- ceruminous gland adenoma/adenocarcinoma
- anal sac adenoma/adenocarcinoma

17

Which tumours do not have squamous or adnexal differentiation?

- basal cell tumour (tichoblastoma)
- basal cell carcinoma

18

Which species has a higher risk of malignant skim neopasia?

Cats (dogs usually benign)

19

5 types of mesenchymal tumour

- fibrous
- vascular/perivascular
- muscle
- neural and pernineural
- lipcytic

20

Clinical presentation of mast cell tumours?

- varies massively!!
-single/multiple
- small/large
- well demarcated/imfiltrive
- firm/soft
- ulcerated/epithelialised
- oedematous/inflam
- pigmented/non-pigmented
> fluctuant swelling and erythema should ^ suspicion
> affect dermis and subcutis
> usually back half of body (perineum, dital limbs, perpuce)
> Boxers, pugs, weimeranas predisposed
- concurrent signs due to histamine, heparin and other vasoactive mediator release: bleeding disorders, immune-mediated thrombocytonpaenia, GI ulceration

21

Are MCT considered benign?

Should be considered potentially malignant

22

Diagnostics

- cytology
- imaging
- buffy coats + BM aspirate
> difficult to interpret

23

Tx MCT

Standard neoplasia surgery, chemo, radiation
-surgery gold stand woith nonode involvement
- intermediate 2cm margins and one deep facial plane
- some dirty margins will not regrow