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Q3 Clin Med II Test 2 (Resp) > Lung CA > Flashcards

Flashcards in Lung CA Deck (31)
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1
Q

Solitary Pulmonary Nodule (SPN) is?

A

“coin lesion” (U) benign

<3cm
defined edges
dense, central calcification

2
Q

SPN risks for malignancy, epidemiology?

A

> 60yo
lifestyle
co-existing lung dz
infection risk/exposure

3
Q

SPN risks for malignancy, physical findings?

A

weight loss
LAD
fixed/local wheeze
joint tenderness

4
Q

SPN imaging findings?

A

Review old films for stability (growth)

↑ risk of malig if:

Φ calcification
poor definition
> 3 cm

5
Q

Small Cell CA characteristics?

A

Bronchial origin (central)
Compresses bronchi
Micrometastases
Poor prog (Φ surgery)

6
Q

Non-small Cell CA (NSC):

Adenocarcinoma characteristics?

A

Most common,
Mucous gland origin (peripheral),
Met to distant organs,
Nodules or masses

7
Q

NSC Squamous Cell CA characteristics?

A

Bronchi epith origin (central),
Hemoptysis common,
Met to regional lymph nodes,
(P) cavitation

8
Q

NSC Large Cell CA characteristics?

A

Lung periphery,
Met to distant organs,
Undifferentiated,
Rapid/aggressive

9
Q

Lung CA presentation:

Primary Lesion sxs?

A
Cough
Sputum
Dyspnea
Hemoptysis
Chest pain
Unilat/Local wheeze
10
Q

Lung CA presentation:

Intrathoracic Spread sxs?

A

Pleural effusion
Pericardial effusion
Hoarseness (compressed laryn n, U L side tumors)

11
Q

Superior Vena Cava Synd is?

A

compression/invasion of SVC

(U) a/w small cell

12
Q

SVC Synd sxs?

A
HA
Dyspnea
Facial/extrem swelling
Plethora
Venous pattern on chest
13
Q

Pancoast Synd is?

A

compression of brachial plexus/cervical sympathetic nn

14
Q

Pancoast Synd sxs?

A
Horner's: Ipsilateral of tumor
miosis
anhidrosis
ptosis
sunken eyeball

Rib destruction
Hand atrophy
Pain C8 - T2

15
Q

Lung CA presentation:

Paraneoplastic Syndromes

A
anorexia
weight loss
wasting
fever
↓ immunity
16
Q

Paraneoplastic Syndromes are?

A

disorders from tumor secretions

hormones, peptides, cytokines

17
Q

Paraneoplastic Syndrome presentation: Hematologic?

A

thrombophlebitis (e.g. Trousseau’s)

hypercoaguability

18
Q

Paraneoplastic Syndrome presentation: Endocrine?

A

PTH-like: hyperCa2+
HCG (gonad): gynecomastia
SIADH: hypoN+
Cushing’s: ACTH

19
Q

Paraneoplastic Syndrome presentation: Neurologic?

A

Eaton-Lambert: NMJ antibodies -> mm weakness

peripheral neuropathy

20
Q

Most common metastasis sites?

A

Liver
Bone
Adrenal gland
Brain

21
Q

Lung CA workup?

A

Tissue dx
Staging
Performance status

22
Q

Staging of SCLC?

A

Limited: in ipsil hemithorax

Extensive: beyond hemi, includes effusion

23
Q

Staging of NSC?

A

TNM system

T - primary tumor
N - nodal involvement
M - distant mets

24
Q

Stage 1?

A

localized

25
Q

Stage 2?

A

in lymph nodes at top of lung

26
Q

Stage 3?

A

into chest wall

27
Q

Stage 4?

A

met elsewhere

28
Q

Performance status: post-op complication predictor is?

A

FEV < 60%

29
Q

Positive Emission Tomo (PET) used for?

A

staging

30
Q

Lung CA management: small cell

A

chemo always

(P) whole brain prophy radiation

31
Q

Lung CA management: non-small cell

A

surgery

Stage IIIa-IV: radiation/chemo