Lung cancer

Question 1

SCLC high yield

Answer 1

Agressive
Sensitive to chemotherapy
Smoking
Surgery is not commonly used

Question 2

Which patients with NSCLC are candidates for surgical resection

Answer 2

Patient diagnosed in early stages (Until stage IIIA)

Question 3

Which lung cancer form is the most common in women?

Answer 3

Adenocarcinoma

Question 4

Adenocarcinoma is frequently (location)

Answer 4

Peripheral

Question 5

Squmous cell carcinoma is more often found in which population?

Answer 5

Smokers

men

Question 6

T1 stage

Answer 6

Tumor < 3 cm

Not involving main bronchus

Question 7

T2 stage

Answer 7

Tumor > 3 cm
or
Involving main bronchus

Question 8

T3 stage

Answer 8

Tumor into the chest wall/diaphragm but nor beyond carina or mediastinum

Question 9

T4 stage

Answer 9

Tumor into the carina and/or mediastinal structures, heart, great vessels

Question 10

N0

Answer 10

No lymph node involvement

Question 11

N1

Answer 11

Ipsilateral peribronchial or hilar nodes

Question 12

N2

Answer 12

Ipsilateral mediastinal or subcranial nodes

Question 13

N3

Answer 13

Contralateral mediastinal/Hilar, supraclavicular, bilateral or scalenus lymph node bil.

Question 14

M0

Answer 14

No metastasis

Question 15

M1

Answer 15

Distant metastasis (Beyond regional lymph nodes)

Question 16

SCLS stage I-III first line of treatment

Answer 16

Ciplatin/ Carboplatin + Etoposide
Chemotherapy 6 cycles
Thoracic radiotherapy is given after the 3rd course

Question 17

SCLS stage IV second line of treatment

Answer 17

Topotecan OR
Epirubicine-Cyclophosphamis-Vincristine
4 cycles

Question 18

NSCLC surgucal treatment is for what stages

Answer 18

IA-IIIA

Question 19

What is Adjuvent chemotherapy?

Answer 19

After surgery to improve the outcome

For patients with stage IB-IIIA

Question 20

What is Neo-Adjuvent chemotherapy?

Answer 20

Before surgery to make the lesion resecable (IIIA)

Question 21

What does Palliative mean?

Answer 21

Relieving pain without dealing with the cause of the condition

Question 22

NSCLC- Contraindication for surgery

Answer 22

Old
MI in past 3 months
Arrhythmias
Pulmonary HTN
Severe COPD

Question 23

NSCLC stages IIIB-IV chemotherapy is based on what?

Answer 23

Platinum

Question 24

When will we give second/third line of treatment?

Answer 24

Id first line fails
or
Progression occurs within 6 months after previous line

Question 25

second/third line of treatment drugs

Answer 25

Docetaxel | Pemetrexed monotherapy

Question 26

Chemotherapy MOA

Answer 26

Kills cells that divide rapidly

Question 27

Chemotherapy side effects

Answer 27

Bone marrow- Myelosuppression GI- Nausea, Vomiting Hair Fatigue Neuropathy

Question 28

Molecular targeted therapy in locally advanced IIIB and metastatis IV adenocarcinoma

Answer 28

Bevacizumab- VEGF inhibitor (With chemotherapy) | Gefitinib, Erlotinib- EGFR Antag. (Tyrosine-Kinase inhibitor)

Question 29

Bevacizumab- VEGF inhibitor side effects

Answer 29

Bleeding Haemoptysis HTN

Question 30

VEGF inhibitor drug name

Answer 30

Bevacizumab

Question 31

What is ALK+

Answer 31

Anaplastic Lymphoma Kinase + Cancer may grow more quickly

Question 32

ALK+ occurs in what % in NSCLC?

Answer 32

5%

Question 33

NSCLC types and %

Answer 33

Adenocarcinoma 40% SCC 25-30% LCC 10-15% Others 15-25%

Question 34

SCLC is usually treated with what and Why?

Answer 34

Chemotherapy | High sensitivity

Question 35

Origin of SCLS

Answer 35

Neuroendocrine cells

Question 36

TNM staging

Answer 36

T 1-4 N 0-3 M 0/1

Question 37

Adenocarcinoma can manifest in what syndrome and why?

Answer 37

Horner syndorme | Pancoast tumor that compress nearby vessels and nerves- Brachial plexus, Cervial symp. chain

Question 38

Horner syndrome

Answer 38

Ptosis Miosis Anhydrosis

Question 39

Which hormone can be released by SCC

Answer 39

Parathyroid hormone

Question 40

Symptoms in case of carcinoid lung cancer

Answer 40

Serotonin/Carcinoid syndrome | Serotonin induced valvular fibrosis and bronchoconstriction, Flushing

Question 41

Most common metastasis sites of lung cancer

Answer 41

``` Bone Liver Lymph Adrenal Brain ```

Question 42

What causes hoarseness?

Answer 42

Recurrent laryngeal nerve palsy

Question 43

If the cancer lesion is present in the middle of the lung, how can we take biopsy?

Answer 43

VATS | Video Assisted Thoracic Surgery