Lung Cancer Drugs

Question 1

What is the MOA & S/E of Cisplatin

Answer 1

DNA alkylating agent
nephrotoxicity, Ototoxicity

Question 2

What is the MOA & S/E of Gemcitabine?

Answer 2

Inhibits DNA synthesis; N/V, Myelosuppression

Question 3

What is the MOA & S/E of Pemetrexed?

Answer 3

inhbiits TS, DHFR; Hand-foot syndrome, Myelosuppression

Question 4

What is the MOA & S/E of Docetaxel/Paclitaxel

Answer 4

binds to tublin; Neuropathy, myelosuppression, hypersensitivity

Question 5

What is the MOA & S/E of Bevacizumab

Answer 5

binds to VEGF isoform and prevents the interaction with its receptors on endotheial cells inhibiting new vessel formation inhibit invasion and metastasis of solid tumor cancer cells
GI perforation thromboembolism

Question 6

What is the MOA & S/E of Erlotinib

Answer 6

EGFR overexpression
skin rash, diarrhea