Lung Cancer -Rajukar Flashcards Preview

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Flashcards in Lung Cancer -Rajukar Deck (17):

Which cancers more commonly present with a cough? Why?

squamous cell and small cell carcinomas

central airway involvement


What cancers will more commonly present with bronchorrhea or cough productive of large volumes of thin, mucoid secretions?

Bronchioalveolar cell carcinoma

indicated advanced disease


What will superior vena cava syndrome present with?

prominent venous pattern on the chest, facial edema and a plethoric appearance

from SVC obstruction from lung cancer


What is Pancoast Syndrome?

When lung cancers arise in the superior sulcus

pain in the shoulder

Horner's syndrome (ptosis, miosis and anhydrosis)

bony destruction

atrophy of hand muscles


Where does lung cancer like to spread to?

*adrenals (asymptomatic)

liver (can elevate liver enzymes)

bone (elevated all phis and Ca2+)

brain (HA, vomiting, visual field loss)


Does a negative pleural fluid cytology rule out involvement of the pleura by lung cancer?



What causes hypercalcemia in lung cancer?

bony metastasis or tumor secretion of PTHrP

Tx: IV fluids and bisphosphonates


What lung cancer can lead to SIADH?

small cell lung cancer

too much ADH secreted --> hyponatremia and dec Urine output


In a diagnosis of lung cancer, what should be checked?

scan of the brain for metastasis

changes treatment and most lung cancer presents in the advanced stages


What lab tests should be ordered in lung cancer?

●Complete blood count
●Alkaline phosphatase
●Alanine aminotransferase (ALT) and aspartate aminotransferase (AST)
●Total bilirubin


What is the sequence of imaging for a suspected lung cancer pt?

Chest X Ray

Computerised Tomography (CT) scan of the Chest with IV contrast

Whole Body (PET) Positron Emission Tomography/CT scan

MRI Brain with Gadolinium


What is the treatment for Stage I and II NSCLC?

Surgery (if adequate lung function)

Stereotactic body radiation therapy

Radio-frequency Ablation

Adjuvant Chemotherapy if Stage II


What is the treatment for Stage III NSCLC?

- Concurrent Chemotherapy and Radiation


What is the treatment for stage IV NSCLC?

Chemotherapy or Targeted therapy

Brain mets: Whole Brain XRT or Gamma-knife XRT

Bone mets: Zoledronic acid or Denosumab


What is the treatment for stage I -III small cell lung cancer?

Cisplatin + Etoposide with Radiation therapy

*Prophylactic Whole-Brain Radiation if good response to Chemoradiation


What is the treatment for Stage IV small cell lung cancer?

Cisplatin/Carboplatin + Etoposide

*Prophylactic Whole-Brain Radiation if good response to Chemotherapy

Irinotecan, Topotecan, Paclitaxel


What is the ECOG performance scale?

scale from 0-4 of how to treat lung cancer

3-4 recommend hospice care--> can't self care --> body can't handle chemo