Lymphedema Flashcards
(39 cards)
What compromises the lymphatic system?
Lymphatic organs:
- Lymph nodes (600-700 in the body): filtering stations that produce WBC and regulate proteins in the lymph
- Lymph vessels: provide intrinsic contractions 6-10x/minute
- Thymus gland
- Spleen
- Tonsils
- Peyer’s patches
Approximately how many lymph nodes are located in the axillary area?
30-40 lymph nodes
What comprises lymphatic vessels?
- Capillaries
- Pre-collectors
- Collectors
- Trunks
Vessels are all different sizes and carry the lymph differently
What are mechanisms of lymph transportation?
- Intrinsic contraction
- Respiration
- Arterial/venous pulsation
- Skeletal movement
- New lymph creates pressure
Where is 3/4 of the body’s lymph drained?
- Into the left side of the thoracic duct
Which direction to lymph valves go?
- Only one way
- Lymph nodes affect the front and back of the body
What makes up lymph fluid?
- Proteins: 75-100 g of proteins are transported by the lymph vessels per day
- Water
- Cells: RBC, WBC, lymphocytes
- Waste products and other foreign substances
- Fat (instestinal lymph, chyle)
How many liters of lymph does the body transport in one day?
- 2-2.5 L/day
How does fluid move from place to place?
- Through pressure gradients
- Diffusion: movement of fluid from high concentration to low concentration
- Osmosis: passage of fluid through semipermeable membrane
- Ultrafiltration: mechanical pressure separates water from protein and pushes water through membrane
Filtration = resorption and lymph flow
What are physiological factors to consider when treating someone with lymphedema?
- Lymphatic Load (LL): how much water, proteins, cells, etc. normally need to move
- Lymph Time Volume (LTV): amplitude and frequency of intrinsic contractions = lymph load
- Transport Capacity (TC) = Max LTV or 10x LL intact system
- Functional Reserve (FR): difference between TC and LL
What is considered normal in the lymphatic system?
- LL (lymphatic load) < TC (transport capacity)
What is dynamic insufficiency?
- The lymphatic system is overloaded: venous insufficiency, cardiac edema, DVT, etc.
- The lymphatic system is still able to move most proteins after swelling
- LL (lymphatic load) > TC (total capacity)
What is mechanical insufficiency?
- TC (total capacity) = LTV (lymph time volume) and LL (lymphatic load is greater than both)
- Lymphedema always includes mechanical insufficiency
- May be due to surgery, trauma, radiation, etc.
- Body is not capable of moving proteins out
What is combined insufficiency?
- Lymphatic load is high and system is damaged
- May be due to obesity, CVI, lipedema
What is the definition of lymphedema?
- An abnormal collection of protein-rich fluid in the interstitium, which causes chronic inflammation and reactive fibrosis of the affected tissues
- The lymph load (LL) exceeds the total capacity of the system
- Can occur anywhere in the body
What is the prognosis for lymphedema?
- There is no cure
- Early detection and management, and patient ability to self-manage yields a good prognosis
- If left untreated, or if poorly managed, then elaphantiasis will occur
What are risk factors for developing lymphedema?
- Axillary, inguinal, etc. surgery
- Radiation
- Partial or total mastectomy
- Node dissection
- Obesity/overweight: less space for lymphatic vessels and they collapse
- Lipedema
- History of infection in at-risk limb
- Constriction
- Tumor causing lymphatic obstruction
- Scarring lymphatic ducts by either surgery or radiation
- Intra-pelvic or intra-abdominal tumors
- Chronic venous insufficiency
- Draining complications
- Burns create compression from scarring so lymphedema is not typically seen in people with burns
- *Tourniquets can damage lymphatic vessels and create lymphedema distal to tourniquet
What are primary causes of lymphedema?
- Mechanical insufficiency of the lymphatic system
- Malformation of lymphatic vessels
- Congenital or hereditary
What are secondary causes of lymphedema?
- Surgery
- Radiation
- Trauma
- Filariasis (parasitic infection)
- Cancer/tumor
- Infection
- Obesity
- Self-induced
What are early signs and symptoms of lymphedema?
- Limb feels heavy
- Skin feels tight
- Limb is achy but not painful
- Clothing or jewelry becomes tight
- Wrinkles in skin are not present
- Fatigue
*There is typically a 30% increase in lymph volume before it is detectable by the human eye
What are the different stages of lymphedema?
- Latency: no visible/palpable edema, subjective complaints possible (heavy and feels tired)
- Stage 1: reversible (elevation), pitting edema often present, increased limb girth and heaviness, no fibrosis. Or edema goes away while sleeping. No skin changes but there may be some pitting
- Stage 2: consistent swelling, does not change with elevation, spongy tissue feeling and often fibrotic changes, pitting becomes progressively more difficult
- Stage 3: lymphostatic elephantiasis, non-pitting, fibrosis, and sclerosis, skin changes (hyperkeratosis)
What are characteristic skin changes that occur with lymphedema?
- Hyperkeratosis
- Lichenification (leathery and hard)
- Peau d’orange texture: can see hair follicles and looks like the peel of an orange. Can be a problem because it may indicate cancer reoccurrence or infection
- Ulcers: may be more common with arterial, neutrotrophic, venous, or traumatic conditions
- Vesicles (cysts or blisters)
- Lymphorea: “weeping”, fluid leaks out of skin and can become stuck to skin - looks yellow
What are complications of lymphedema?
- Infection: a medical emergency (cellulitis, dermatitis, lymphangitis, etc.)
- Reflux
- Lymphorea
*It is important to educate pts with lymphedema that they are at an increased risk of infection
What are lymphedema medical diagnostics and management?
- Medications: no evidence of medication aiding treatment
- Surgeries: currently, there are no surgeries to cure lymphedema. There are lymph node transplants and there used to be debulking (very dangerous and intense)
Tests and Measures:
- Lymphoscintoigraphy: nuclear imaging method, tissue injection is transported by lymphatic system and allows assessment of superficial and deep lymphatics, no damage to lymph vessels
- Venography and Doppler US: to rule out venous problems/DVT
- Lymphedema is normally determined by clinical diagnosis
*Diuretics can cause fibrosis