Lymphocytes and Co-stimulatory receptors

Question 1

What type of immune response do T & B cells have?

Answer 1

Adaptive

Question 2

What type of immune response do NK cells have?

Answer 2

Innate

Question 3

Three lymphocytes?

Answer 3

NK cells = innate
T cells = cellular
B cells = humoral

Question 4

Lymphocyte locations?

Answer 4

lymphoid organs, bone marrow, lymph nodes, intestine, peyers patches/ spleen, blood

Question 5

Lymphocytes originate from

Answer 5

bone marrow stem cells

Question 6

T cells from

Answer 6

thymus

Question 7

Plasma cells produce

Answer 7

antibodies

Question 8

B cells are from

Answer 8

Bursa

Question 9

All adaptive immune response starts in the

Answer 9

secondary lymphoid organs

Question 10

Memory B cells

Answer 10

recognize antigen & divide in plasma cells

Question 11

T helper cells that help trigger immune response

Answer 11

Th1, 2, 17

Question 12

Th1 stimulation will trigger

Answer 12

cellular immune response

Question 13

Th2 stimulation will develop

Answer 13

antibodies humoral immune response

Question 14

Th17 stimulation is only

Answer 14

humoral but not as important as Th2

Question 15

Thymus

Answer 15

• T cells
• Paracortex lymph nodes
• Periarteriolar lymphoid sheets of spleen
• interfollicular areas in peyers patches
• 60-80% lymphocytes in blood

Question 16

Bone marrow/ Bursa of Fabricus

Answer 16

• B cells
• Follicles in peyers patchs
• Cortex of lymph nodes
• Marginal zone in white pulp of spleen
• 10-40% lymphocytes in the blood

Question 17

Tolerance

Answer 17

lack of immune response

Question 18

Effector T cells

Answer 18

cytotoxic T cells to recognize infected cells w/ intracellular pathogens
-works on cancer cells, transplants, skin grafts rejected

Question 19

B cells

Answer 19

• BCR-immunoglobulin
• immunoglobulins
• free foreign proteins
• Difficult tolerance induction
• Plasma cells, memory cells progeny cells
• immunoglobulins secreted

Question 20

T cells

Answer 20

• TCR-protein (CD3, CD4, CD8)
• Processed foreign proteins in MHC antigens
• easy tolerance induction
• effector T cells, memory T cells progeny cells
• Cytokines secreted

Question 21

TCR (T cell antigen receptor) types:

Answer 21

TCR α/β

TCR γ/δ

Question 22

BCR (B cell antigen recpetor) types:

Answer 22

BCR α
BCR γ
BCR μ
BCR ε
BCR δ

Question 23

Antibodies and B cell receptors are the same except

Answer 23

antibodies are free and B cell receptors are attached to cell membrane

Question 24

What is the main function of T & B cell receptors?

Answer 24

to bind/recognize specific antigens

Question 25

CD3

Answer 25

present in all T cells

Question 26

CD4

Answer 26

present in all Th cells | -receptor for MHC II

Question 27

CD8

Answer 27

present in all cytotoxic T cells (Tc) | -receptor for MHC I

Question 28

T cell receptor function?

Answer 28

recognize the antigen

Question 29

Transport receptor

Answer 29

transferrin CD71

Question 30

Regulatory Receptors (T cells):

Answer 30

- Histamine-H3 - Immunoglobulins-FcR - Complement- CD35, C3b, C4b - IL-2 - CD25 - CD58 - CD2

Question 31

What could be the effects on T cells activation?

Answer 31

- cell division, proliferate - cell differentiation - macrophages are activated release of cytokines

Question 32

B cell receptors:

Answer 32

``` Complement receptors (IL-2, 4, 5) Antigen receptor (BCR) Cytokine receptors (C3b, C4b) Immunoglobulin receptors (IgM, IgG, IgE) ```

Question 33

B cell activation effects?

Answer 33

produce antibodies, dividing, differentiating plasma Vs memory cells

Question 34

Integrins

Answer 34

B1 (integrins, fibronectin, laminin, collagen) | B2 (integrins, intracellular adhesion molecule 1)

Question 35

Selectins in vascular endothelial cells

Answer 35

P-selectin L-selectin E-selectin

Question 36

Lymphocyte mitogens

Answer 36

``` Phyytohemagglitinin Concanavalin Pokeweed Lipopolysaccharide Bacille Calmette-Guerin Red Kidney Bean Jackbean Gram - bacteria Mycobacterium ```

Question 37

Molecules/receptors that can regulate the lymphocyte functions:

Answer 37

cytokines, antibodies, compliment, antigen- can all modify behavior of T & B cells

Question 38

CD4 & CD8 are expressed on

Answer 38

T cells, NOT B cells