Lymphocytic Cellular Maturation Flashcards Preview

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Flashcards in Lymphocytic Cellular Maturation Deck (8)
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1
Q

What are the different moleculars T-cells and B-cells can bind to and detect?

A

B-cells can bind anything in the plasma that is large enough from surface protein to chemicals in blood.
T-cells only bind to MHC molecules, Class I and II

2
Q

What kind of chains are used for B and T-cells?

A

B-cells – Heavy and Light Chains – Kappa/Lambda

T-cells – Alpha / Beta Chains

3
Q

How can B and T-cells make so many different combinations of antigenic receptors?

A
  • -VDJC gene segements with multiple versions of each kind
  • -Junctional Diversity, when nucleotides are added/subtracted
  • -Hypermutation of gene segments (due to high use)
4
Q

What is the interluken that is key to maturation of lymphocytes?

A

IL-7

5
Q

When is the IgD lost from the surface of B-cell?

A

IgD is present until it matures after exposure to antigen in the lymph tissue.

6
Q

What are the steps of positive and negative selection of T-cells in the Thymus?

A

Positive Selection – must bind to self antigens at least partially, then Negative selection if they bind too tightly.

7
Q

Where does positive and negative selection occur in the thymus?

A
Positive = Cortex
Negative = Medulla
8
Q

What is the difference between B and T-cell maturation and clonal expansion?

A
  • -B-cells leave the bone marrow and do not mature into plasma cells/clonal expansion until they encounter their corresponding antigen (Mantle–>Germinal Center)
  • -T-cells mature in the thymus and go to the paracortex in lymphnodes and expanding when needed instructed to.