Lymphoid Disorders Flashcards by Shirley Yancey

Q

CD20

A

Mature B cells

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Q

CD10

A

Precursor B ells, germinal center cells

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Q

CD3

A

Pan-T cell markers

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Q

CD34

A

Myeloid and lymphoid precursors

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Q

White pulp enlargement of spleen caused by:

A

B cell lymphomas

Lymphoid hyperplasia

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Q

Red pulp enlargement of spleen caused by:

A

Congestion
Leukemia
Autoimmune processes

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Q

Benign reactive processes of unknown etiology

A

Lymphadenopathies

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Q

Immunophenotype of reactive lymphoid hyperplasia

A

CD20+, CD10+, bcl 6+, **bcl-2- in germinal centers

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Q

Most common cause of lymph enlargement in adults

A

Neoplasia

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Q

Lymphoid neoplasias common in children and young adults

A

Hodgkins Lymphoma

Burkitt Lymphomas

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Q

Most common lymphomas (2)

A

Diffuse large B cell lymphoma

Follicular lymphoma

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Q

Follicular lymphoma Immunophenotype

A

CD20+, **Bcl 2+, **CD10+, CD3-

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Q

Follicular lymphoma cytogentics

A

Bcl 2 gene rearrangement: t(14;18)

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Q

Most common type of lymphoma

A

Diffuse large B cell lymphoma

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Q

Immunophenotype of Burkitt lymphoma

A

CD19+, CD20+, *CD10+, Bcl 6+, Bcl-2-

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Q

Cytogenetics of Burkitt Lymphoma

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A

t(8;14)

Q

Immunophenotype for Mantle Cell Lymphoma

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A

CD19+, CD20+, CD5+, cyclin D1+

Bcl-6-, *CD10-, CD23-

Q

Cytogenetics of Mantel Cell Lymphoma

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A

t(11;14)

Q

Associated w/ helicobacter pylori

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A

Marginal zone lymphoma

Q

Immunophenotype of Hodgkin Lymphoma

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A

CD30+, CD15+, CD45-

Q

Chronic Lymphocytic leukemia/small lymphocytic lymphoma immunophenotype

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A

CD19+, CD20+, CD5+, Cd23+

Q

Low grade B cell lymphomas (4)

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A

Follicular
Marginal zone
Mantle
Small Lymphocytic

Q

CD5+, CD20+, CD23+, CD10-

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A

CLL/SLL

Q

CD10+ CD20+, CD5-, CD23-

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A

Follicular Lymphoma

CD5+, CD20+, CD10-, CD23-

Mantle Cell Lymphoma

CD10+, CD20+, CD5-, CD23-

Burkitt

CD20+, Cd5-, CD10-, CD23-

Mantle Zone Lymphoma

CD19

precursor B cells, mature B cells