Lymphoma

Question 1

Define Hodgkin’s lymphoma

Answer 1

Contagious malignant tumour of lymphatic system/spleen

Question 2

Abnormal B cells that are unique to Hodgkin lymphoma

Answer 2

Reed Sternberg cells

Question 3

Age distribution and peak of Hodgkin’s

Answer 3

• bimodal

- 20 & 75 yo

Question 4

Best prognosis type of Hodgkin’s

Answer 4

Lymphocyte predominant

Question 5

Worst prognosis type of Hodgkin’s

Answer 5

Lymphocyte depleted

Question 6

Good prognosis type of Hodgkin’s that is associated with a large number of Reed-Sternberg cells

Answer 6

Mixed cellularity

Question 7

Good prognosis type of Hodgkin’s that is common in women and is associated with lacunar cells

Answer 7

Nodular sclerosing

Question 8

Presentation of cervical and supraclavicular lymphadenopathy

Answer 8

• painless
• rubbery
• non-tender

Question 9

Pain in lymph nodes due to Hodgkin’s is worsened by

Answer 9

Alcohol

Question 10

Systemic effects of Hodgkin’s

Answer 10

• night sweats
• weight loss
• fever
• chest problem

Question 11

Virus that increases the risk of Hodgkin’s

Answer 11

EBV

Question 12

Chemical substance that increases the risk of Hodgkin’s

Answer 12

Benzene

Question 13

Gender more at risk of Hodgkin’s

Answer 13

Men

Question 14

Ann Arbor stage I

Answer 14

Single lymph node region

Question 15

Ann Arbor stage II

Answer 15

Two or > node regions. On same side of diaphragm

Question 16

Ann Arbor stage III

Answer 16

Node regions on both sides of diaphragm

Question 17

Ann Arbor stage IV

Answer 17

Dissemination to one or more extra lymphatic organs or tissues

Question 18

What are Reed Sternberg cells found in lymph nodes in core needle biopsy

Answer 18

Nuclei w/ nucleoli inside them

Question 19

CD changes in core needle biopsy

Answer 19

+CD15/CD30

Question 20

Why are low Hb & high LDH (lactate dehydrogenase) not good enough to diagnose lymphoma

Answer 20

Not specific

Question 21

FBC findings in hodgkin’s

Answer 21

• anaemia
• lymphopenia
• neutrophilia
• eosinophilia

Question 22

Chemotherapy agents

Answer 22

• adriamycin
• bleomycin
• vinblastine
• darcabazine

Question 23

SEs of chemotherapy

Answer 23

• leukaemia

- infertility

Question 24

SEs of radiotherapy

Answer 24

• hypothyroidism
• cancer
• nephrotic syndrome
• amyloidosis

Question 25

Definition of non-Hodgkin’s

Answer 25

Umbrella term for non-lymphoid

Question 26

Differential of Hodgkin’s from non-Hodgkin’s

Answer 26

No Reed-Sternberg cells

Question 27

Chemical exposure that increases the risk of non-Hodgkin’s

Answer 27

Trichloroethylene

Question 28

Viruses (& bac) that increase the risk of non-Hodgkin’s

Answer 28

- HIV - EBV - Hep B/C - H pylori

Question 29

H pylori in lymphoma is associated with

Answer 29

Gastric MALT (mucosa-associated lymphoma tissue)

Question 30

EBV in lymphoma is associated with

Answer 30

- Burkitt’s lymphoma - AIDS-related CNS lymphoma - malaria

Question 31

Hep C in lymphoma is associated with

Answer 31

- diffuse large B cell lymphoma | - splenic marginal zone lymphoma

Question 32

Human T cell lymphotropic virus type 1 is associated with

Answer 32

T-cell lymphoma

Question 33

Diffuse large B cell lymphoma in over 65 is characterised by

Answer 33

Rapidly growing

Question 34

Presentation of non-Hodgkin lymphoma

Answer 34

- painless lymphadenopathy - symmetrical - multiple sites - spread discontinuously across nodal sites

Question 35

Systemic and organ-specific symptoms of non-Hodgkin lymphoma

Answer 35

- fever - night sweats - weight loss - splenomegaly - hepatomegaly

Question 36

Blood films reveal what in NH lymphoma

Answer 36

- uncleared red cells | - left shift

Question 37

Tx options for NH lymphoma

Answer 37

- chemo/radio - stem cell transplant - monoclonal Ab (rituximab)