Lymphoma 2 Flashcards
(21 cards)
What cell type occurs classically with Classical HL?
Reed Sternberg cells
What does painless lymphadenopathy cause clinically if it is superficial?
Palpable lymph nodes
What does painless lymphadenopathy cause clinically if it is deep?
Obstructive symptoms
What are the types of Classical Hodgkin Lymphoma that can occur ?
Lymphocyte rich/depleting
Mixed cellularity
Nodular sclerosing
How does HL progress?
Starts in 1 lymph node
progresses continuously through lymph node route
What is the fastest growing human cance3r?
Burkitts (NHL)
How do you treat NHL?
More complex than with HL
Chemotherapy
Monitor (watch and wait)
Antibiotic eradication *H pylori(
How does curability relate to aggression of lymphoma?
The more aggressive the more CURABLE
What is tx of DLBCL
R CHOP
Rituximab Cyclophosphamide Doxorubicin Vincristine Prednisolone
What is the translocation in follicular NHL?
t(14,18)
What is the gene overexpressed in follic NHL?
Bcl2
What is treatment for follic NHL?
R CVP
Rituximab Cyclophosphamide Vincristine Prednisolone
What tissue is involved in a marginal zone NHL?
EXTRANODAL lymphoid tissue
What are examples diseases causing MZL?
Sjogrens = parotid lymphoma
H pylori = gastric MALToma
Hashimotos thyroiditi = thyroid
Psittaci infection = lacrimal gland
What is the usual number/letter presentation of MZL
Stage 1 E (single site, extranodal)
What are findings of CLL?
lymphocytosis
Smear cel;;s
Normocytic normochromic anaemia
Thrombocytopoenia
What kind of cancer is CLL (indolent or aggressive)???
INDOLENT
What antigen expression on B cells confirms CLL?
CD5 POSITIVE
CD19 negative
*CD5 is normally present only on immature B cells
What is supportive tx for CLL?
VACCINATION (flu, pneumococcus) - NOT VZV because live
Anti-infective prophylaxis &tx (acyclovir)
what chemo is given for TP53 intact CLL?
FCR
What therapy is given for TP53/17p deletion CLL?
Ibrutinib (bruton TK inhibitor)
Venetoclax (anti Bcl2)
