lymphoma general

Question 1

what means haematological cause instead of non-haematological

Answer 1

lymphocyte >20

Answer 2

leukemia - bone marrow
lymphocytoma - lymph nodes

Answer 3

acute leukemias and high grade NHL and hodgkins - curable but aggressive

chronic leukemias and low grade NHL - non aggressive but cant be cured

Question 4

differentiate test results

Answer 4

ALL:
- >20% blasts
- abnormal FBC
- anaemia
- low platelets
- WBB may be high

CLL:
- >5X10^9 lymphocytes
- Low everything else

hodgkins:
- anaemia
- high WBC + platelet
- raised ESR

high grade NHL:
- may be normal
can have cytopenia <10%
- raised LDH

low grade NHL:
- may be normal
- lymphoctosis can be seen
- cytopenias if marrow involvement

Question 5

which has philidelphia gene involvement?

Answer 5

ALL

Question 6

bone marrow biopsy

Answer 6

ALL

Question 7

Peripheral blood flow cytometry

Answer 7

CLL

Question 8

which have the like biphasic age

Answer 8

ACL
hodgkins

Question 9

serum LDH elevation?

Answer 9

high grade NHL

Question 10

raised ESR?

Answer 10

hodgkins

Question 11

reed sternberg

Answer 11

hodgkins

Question 12

contrast symtpoms

Answer 12

ALL:
all

CLL:
mostly assymptomatic

hodgkins:
rubbery, painless, worse w alcohol lymphadenopathy

low grade:
stomach issues

Question 13

starry sky appearance

Answer 13

burkitts lymtpoma

Question 14

translocation between chromosomes 8 and 14

Answer 14

burkitts lymphoma

Question 15

richters fransformation

Answer 15

progression of an aggressive lymphoma - usually diffuse B cell

Question 16

asymmetrical painless lymphadenopathy

Answer 16

hodgkins

Question 17

translocation between chromosomes 11 and 14

Answer 17

mantle cell

Question 18

best prognosis hodgkins

Answer 18

lymphocyte predominant

Question 19

smudge cells

Answer 19

CLL

Question 20

EBV

Answer 20

hodgkins

Question 21

H.pylori and hepC

Answer 21

low grade NHL