Lymphoma (Hodgkin + non-Hodgkin) Flashcards
(35 cards)
What cells does lymphoma affect?
lymphocytes
What percentage of lymphomas are non-Hodgkins?
What percentage of lymphomas are Hodgkins?
Give four risk factors for Hodgkins lymphoma
Exposure to pesticides and certain industrial chemicals is a risk factor for which type of lymphoma?
Helicobacter pylori and hep B + C are rick factors for which type of lymphoma?
What cells are affected in Hodgkin’s lymphoma?
What do B-cells mutate into in Hodgkin’s lymphoma?
What’s the main distinguishing feature between HL and NHL?
HL has presence of Reed-Sternberg cells
what are the two types of HL and how often are they both seen?
classical - presence of both RS cells and Hodgkin cells
nodular lymphocyte predominant - have lymphocyte-predominant cells (a variant of RS cells)
What are the four subtypes of classical HL?
What’s the most common symptom of HL?
painless, rubbery, enlarged lymph nodes
What are the B-symptoms associated with lymphoma?
fever
night sweats
weight loss > 10%
what two antigens are almost always expressed on RS cells in HL?
CD15 and CD30
What staging is used in HL?
Ann-arbor staging
What’s stage 1 in Ann-Arbor staging of HL?
What’s stage 2 in Ann-Arbor staging of HL?
What’s stage 3 in Ann-Arbor staging of HL?
What’s stage 4 in Ann-Arbor staging of HL?
What does the A suffix mean in Ann-Arbor staging of HL?
What does the B suffix mean in Ann-Arbor staging of HL?
What does the X suffix mean in Ann-Arbor staging of HL?
Give the name of the staging used in Hodgkin’s lymphoma and describe a patient who is diagnosed
with StageIIIB (4 marks)
- Ann Arbor Staging (1)
- Multiple lymph nodes affected (1)
- Above and below the diaphragm (1)
- Presence of B symptoms (1)
a.)
FBC - anaemia + high ESR (2)
CXR - wide mediastinum
blood film - Reed-Sternberg cells
b.)
HL
c.)
ABVD (chemotherapy combination)
bone marrow transplant (enables a higher dose of chemotherapy to be given)
NOTE: bone marrow transplant = stem cell transplant
