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Year 5 > Lymphomas > Flashcards

Lymphomas Flashcards

1
Q

Most common Lymphoma?

A

B-cell NHL

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2
Q

What are the subtypes of B-cell NHL?

A

There are 6:

  • Follicular
  • Small lymphocytic lymphoma
  • Marginal zone lymphoma (MALT)
  • Mantle cell lymphoma
  • Burkitt’s lymphoma
  • Diffuse large B-cell lymphoma
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3
Q

Follicular lymphoma

A

Type of B-cell NHL

Presentation

  • Elderly patients
  • Indolent

Features

  • t(14;18)
  • BCL2 +ve
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4
Q

Small lymphocytic leukaemia

A

CD23 +
CD5 +
Can undergo Richter transformation

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5
Q

Marginal zone lymphoma (MALT)

A

Due to chronic antigenic stimulation

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6
Q

Mantle cell lymphoma

A

t(11;14)
Cyclin D1 +ve
CD5 +ve

Middle aged men, poor prognosis

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7
Q

Burkitt’s lymphoma

A
  • Associated with EBV
  • STARRY SKY
  • BCL6 +ve
  • t(8;14) c-Myc translocation
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8
Q

Diffuse large B-cell lymphoma

A

Sheets of aggressive lymphocytes

Tx with CHOP

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9
Q

What are the types of T-cell lymphoma?

A
  • Anaplastic large cell lymphoma
  • Adult T-cell Leukaemia/Lymphoma
  • Cutaneous T-cell lymphoma
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10
Q

Anaplastic large cell lymphoma

A

Aggressive lymphoma in children and young adults
t(2;5)
ALK1 +ve

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11
Q

ATLL

A

HTLV1

Caribbean/Japanese

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12
Q

Cutaneous T-cell Lymphoma

A

associated with mycosis fungoides

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13
Q

Classical hodgkin’s Lymphoma

A

CD15 +ve

CD30 +ve

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14
Q

Nodular sclerosing Hodgkin’s lymphoma

A

CD15 -ve
CD30 -ve
CD20 +ve

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15
Q

Which is the most common type of Hodgkin’s lymphoma?

A

Nodular sclerosing

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16
Q

What staging system is used for lymphoma?

A

ANN ARBOR STAGING

  1. One group LNs affected
  2. Two groups LNs affected, same side of diaphragm
  3. Two groups of LNs affected, different sides of diaphragm
  4. Widespread disease i.e. multiorgan involvement

A - no FLAWS
B- FLAWS symptoms

Year 5 (22 decks)

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