Lysosomal jigsaw

Question 1

Describe the lysosomal system.

Answer 1

Question 2

Describe protein trafficking to lysosomes.

Answer 2

Question 3

Describe the secretory membrane system.

Answer 3

Question 4

Why is lysosomal degradation important?

Answer 4

Question 5

Describe autophagy with regards to the lysosomal pathway.

Answer 5

Question 6

What are the common lysosomal storage diseases?

Answer 6

Question 7

Why is autophagy important?

Answer 7

Question 8

Gaucher Disease

Answer 8

Question 9

What is the difference between GAGs and glycoproteins?

Answer 9

Question 10

What is the difference between o-linked and n-linked glycosylation initiation?

Answer 10

Question 11

Answer 11

D

Question 12

What are glycosaminoglycans (GAGs) and how are they formed?

Answer 12

Question 13

How are GAGs degraded in the body?

Answer 13

Question 14

What are the diseases associated with inability to degrade GAGs called? What are the most common ones?

Answer 14

Lysosomal storage disorders

Question 15

Answer 15

B and D

Question 16

What targets the lysosomal hydrolases to the lysosome? Where does this occur?

Answer 16

Question 17

What disease is associated with lysosomal hydrolase targeting?

Answer 17

Question 18

Answer 18

C

Question 19

How does the lysosome degrade compounds?

Answer 19

Question 20

Why do lysosomal storage diseases occur? What is the molecular basis of the symptoms?

Answer 20

Question 21

How are lipids classified? Which are important to Lysosomal storage disorders?

Answer 21

Question 22

What are sphingophospholipids and how are they formed?

Answer 22

Question 23

How are sphingophospholipids degraded? What lysosomal storage disorder is associated with this process?

Answer 23

Question 24

What is the difference between type A and type B Niemann-Pick disease?

Answer 24

Question 25

What are glycolipids and where are they found?

Answer 25

Question 26

How do glycolipids and sphingomyelin differ?

Answer 26

Question 27

What are the types of glycosphingophospholipids and how are they synthesized?

Answer 27

Question 28

How are glycosphingophospholipids degraded?

Answer 28

Question 29

lysosomal storage disease origin

Answer 29

Question 30

How does the dysfunction of glycolipids degradation lead to tay-sachs and gaucher disease?

Answer 30

Question 31

What are the disorders of degradation associated with sphingolipids?

Answer 31

Question 32

What is the histological presentation of tay-sachs disease?

Answer 32

Question 33

What is the histological presentation of Gaucher disease?

Answer 33

Question 34

How are lysosomal storage disorders diagnosed and treated?

Answer 34

Question 35

pathway of glycosphingophospholipid formation and degradatory issues

Answer 35