M1: Specific Proteins (additional)

Question 0

In plasma protein, 35-50g/L is

Answer 0

Albumin

Question 1

Concentration of plasma proteins

Answer 1

65-80g/L

Question 2

Amount of serum globulins which consist of transport proteins, reactants of acute phase & globulins

Answer 2

20-35g/L

Question 3

How albumin is degraded

Answer 3

Hepatocytes, mononuclear phagocytic system (complexes of antigen-antibody, hemoglobin-haptoglobin.

Question 4

Biosynthesis of plasma proteins: most responsible

Answer 4

Liver

Question 5

Biosynthesis of plasma proteins: immunoglobulins

Answer 5

Lymphocytes

Question 6

Types of plasma proteins

Answer 6

Albumin, Globulin & Fibrinogen

Question 7

Protein moves in an electric field according to their charge & size

Answer 7

Electrophoresis of plasma proteins

Question 8

Main component of the globulin which contain its bulk

Answer 8

Albumin

Question 9

Carry fatty acids, bilirubin, calcium & drugs

Answer 9

Albumin

Question 10

Colloidal and non diffusable and exert a coloidal osmotic preessure. Catalytic functions. Most impt in regulation of colloidal and oncotic pressure.

Answer 10

Albumin

Question 11

Protective function which combine with foreign antigens and remove them.

Answer 11

Immunoglobulins

Question 12

Protects the lung tissue

Answer 12

A1 antitrypsin

Question 13

Breaks down thrombin and dissolves clot

Answer 13

Plasmin

Question 14

Plasma proteins are mostly synthesized in the

Answer 14

Liver

Question 15

Immunoglobulins are synthesized in the

Answer 15

Plasma cells

Question 16

Exception as glycoprotein

Answer 16

Albumin

Question 17

Conditions like cell destruction, reversible cell damage & metabolic activation

Answer 17

Acute Phase Reactants

Question 18

Fraction that migrates in a position faster than albumin toward the anode. Tetrameric structure with a total MW of 62000 Da, each monomer can bind a molecule of thyroxine.

Answer 18

Prealbumin

Question 19

Small fraction of thyroxine is bound to TBPA because TBG has 100x greater affinity for thyroxine.

Answer 19

Transthyretin/TBPA (TTR)

Question 20

Role in metabolism in Vitamin which form a complex with RBP. Rich in tryptophan. Short half life 2 days.

Answer 20

Pre albumin

Question 21

Disease affecting pre albumin

Answer 21

Type I Familial Amyloidotic Polyneuropathy

Question 22

2/3 of total protein. Mobile repository of AA for incorporation into other proteins.

Answer 22

Albumin

Question 23

Biosynthesis of plasma proteins:

Answer 23

Analbuminemia

Question 24

Major component of the a1-globulins is the protease inhibitor AAT combine with and inactive trypsin

Answer 24

A1 antitrypsin

Question 25

Released following inflammation responding to irritants

Answer 25

Elastase

Question 26

Best procedure to measure albumin, haptoglobin & complement

Answer 26

Mephelometry

Question 27

Largest major nonimmunoglobulin in plasma, MW 725 000 Da comparable to that of the major protease inhibitor AAT, although women have higher levels than men in response to estrogen.

Answer 27

A2- macroglobulin

Question 28

A2- macroglobulin are high in what condition. More than 3g/dL

Answer 28

Nephrotic syndrome

Question 29

AM2 can be identified by

Answer 29

Isoelectric focusing

Question 30

Form a complex. No globin. See bubbles due to release of catalase.

Answer 30

Haptoglobin

Question 31

Bubbles of oxygen due to

Answer 31

Catalase

Question 32

Circulation of haptoglobin

Answer 32

Reticulo endothelial system

Question 33

Can fresh or stored. C3 cleaved to for C3c them migrate to go to b-globulins

Answer 33

Complement

Question 34

Complement deficient protein diseases

Answer 34

Autoimmune

Question 35

More appreciated in electrophoresis

Answer 35

C3

Question 36

Most abundant of the coagulation factors and which forms fibrin clot

Answer 36

Fibrinogen

Question 37

Produces covalent bonds between lysine and glutamine residues. A crosslinked clot is refractory to dissolution.

Answer 37

Factor XIII

Question 38

Functionally deformed fibrinogen. Bleeding problem and more prone to formation of thrombus or clot.

Answer 38

Dysfibrinogenemias

Question 39

Essentially no fibrinogen is synthesized results in hemorrhagic disorder

Answer 39

Congenital Fibrinogenemia

Question 40

Is a copper binding protein and exhibit oxidase activity. Low at birth and increases in pregnancy, blue color copper then react to yellow chromagens.

Answer 40

Ceruloplasmin

Question 41

Greenish if impaired

Answer 41

Ceruloplasmin

Question 42

Hepatolenticular degeneration

Answer 42

Wilson's dse

Question 43

Group specific component globulin. Decreased in sever liver disease. D binding protein. In middle of albumin and gamma. Can be found in nephrotic syndrome.

Answer 43

Vitamin D

Question 44

Methods for Vit D

Answer 44

Rocket, radioimmunoassay

Question 45

Orosomucoid High CHO content. Binds to drugs like lidocaine. Acute phase reactants.

Answer 45

A1 acid Glycoprotein

Question 46

Pneumococcal infections, rises strikingly whenever there is tissue necrosis. Capacity to precipitate the C substance.

Answer 46

CRP

Question 47

Highly specific for neutralizing chymotrypsin which cleaves peptide bonds at the carboxyl side of tyrosine and phenylalanine residue

Answer 47

AAC

Question 48

Response to inflammatory or stressful states that occur with infection or anything that has something to do with

Answer 48

APRs

Question 49

Due to malnutrition or gross loss of protein

Answer 49

Hypoproteinemia

Question 50

Cut off for nephrotic syndrome albumin

Answer 50

3

Question 51

Loss of transferrin

Answer 51

Iron deficiency anemia

Question 52

Transferrin band forms a narrow clonal

Answer 52

Myeloma protein