m2m section 1 drugs

Question 1

AZT

Answer 1

Inhibit reverse transcriptase DNA synthesis, lack 3’-OH. Treats hiv

Question 2

DDI

Answer 2

Inhibit reverse transcriptase DNA synthesis, lack 3’-OH. Treats hiv

Question 3

Cisplatin

Answer 3

DNA alkylating chemotherapy agent

Question 4

Actinomycin D

Answer 4

Binds DNA at transcription initiation complex, prevents elongation of transcription; intercalation into DNA, prevent replication

Question 5

Doxorubicin (adriamycin)

Answer 5

DNA intercalating chemotherapy agent, disrupts topoisomerase, very effective

Question 6

Etoposide

Answer 6

Disrupts topoisomerase so DNA remains broken

Question 7

Camptothecin

Answer 7

Disrupts topoisomerase so DNA remains broken

Question 8

Puromycin

Answer 8

Mimics tRNA structure, halts translation

Question 9

Tamoxifen

Answer 9

Mimics estrogen but when bound to receptor, halts recruitment of HATs

Question 10

Interferon (NOT DRUG, BUT PROTEIN?)

Answer 10

Phosphorylate eIF2, which shuts down translation; iniation by bringing in Methionine…also activates endonuclease activity

Question 11

Alpha-amanitin

Answer 11

Non-competitive inhibitor of RNA pol II, binds to bridge helix & halts translocation

Question 12

Rifampicin

Answer 12

Antibiotic, blocks RNA exit channel & elongation

Question 13

Gleevec

Answer 13

Inhibits BCR-ABL (Fusion Protein) tyrosine kinase and tumor cell proliferation. Used to treat CML

Question 14

Bortezomib

Answer 14

Proteosome inhibitor. Used to treat Multiple Myeloma

Question 15

Cyclosporin

Answer 15

Inhibits cyclophilin (PPI) and calceneurin, leading to immunosuppressant

Question 16

Rapamycin

Answer 16

Inhibits mTOR, which consequently allows dephosphorylation of eIF4e-BP. eIF4e-BP binds to eIF4e and prevents it from binding to 5’cap & translate.

Question 17

Ritonavir

Answer 17

A competitive inhibitor that targets HIV proteases.

Question 18

Penicilin

Answer 18

An irreversible inhibitor that inhibits bacterial cell wall growth (inhibits peptidoglycan formation).

Question 19

Streptomycin (aminoglycoside)

Answer 19

Inhibit prokaryote initation & elongation during translation

Question 20

Erythromycin (macrolide)

Answer 20

Inhibit prokaryote peptidyl transferase

Question 21

Tetracycline

Answer 21

Inhibit prokaryote aminoacyl tRNA binding

Question 22

Chloramphenicol

Answer 22

Inhibit prokaryote peptidyl transferase

Question 23

Vasopressin (Anti-diuretic HORMONE)

Answer 23

Anti-diuretic peptide hormone. Treats diabetes insipidus

Question 24

Quinolones

Answer 24

Inhibits gyrase

Question 25

Vorinostat

Answer 25

HDAC inhibitor