M4 QUALITATIVE PLATELET DISORDERS (ACQUIRED)

Question 1

structural and functional modifications of
arachidonic acid pathway enzymes

Answer 1

ASPIRIN-LIKE DEFECTS

Question 2

inhibition of cyclooxygenase

Answer 2

ASPIRIN-LIKE DEFECTS

Question 3

absence or abnormalities of the components of the
thromboxane pathway

Answer 3

ASPIRIN-LIKE DEFECTS

Question 4

Ibuprofen

Answer 4

Inhibits platelet function

Question 5

Thromboxane -

Answer 5

Activate neighboring platelets

Question 6

Bleeding caused by platelet dysfunction

Answer 6

UREMIA

Question 7

UREMIA:
Circulating ____ or ___ Interference

Answer 7

guanidinosuccinic acid (GSA) or
hydroxy phenolic acid

Question 8

GSA (Guanidinosuccinic Acid) is a ____

Answer 8

NO (Nitric Oxide)
donor which is a platelet inhibitor

Question 9

COX INHIBITOR

Answer 9

ACETYLSALICYLIC ACID (ASPIRIN)

Question 10

ACETYLSALICYLIC ACID (ASPIRIN)
Interferences:

Answer 10

1. Platelet membrane receptor sites
2. Prostaglandin synthesis
3. Phosphodiesterase activity

Question 11

competitive inhibitors of cyclooxygenase

Answer 11

IBUPROFEN AND RELATED COMPOUNDS

Question 12

COX-1 (Irreversible)

Answer 12

Aspirin

Question 13

COX-1 (reversible)

Answer 13

Naproxen
Sulfinpyrazone
Ibuprofen

Question 14

ADP P2Y12 (Irreversible)

Answer 14

Clopidogrel
Prasurgel

Question 15

ADP P2Y12 (reversible)

Answer 15

Ticagrelor
Cangrelor

Question 16

Thrombin PAR-1

Answer 16

Vorapaxar

Question 17

Sticky Platelet Syndrome

Answer 17

HYPERAGGREGABLE PLATELETS

Question 18

autosomal dominant, thrombophilic disorder that is
associated with venous and arterial thromboembolic
events.

Answer 18

STICKY PLATELET SYNDROME

Question 19

Overactivation of the agonist

Answer 19

STICKY PLATELET SYNDROME

Question 20

aggregation in response to
in vitro stirring only

Answer 20

spontaneous aggregation

Question 21

Stormorken

Answer 21

Fibrin Clot

Question 22

Sticky Platelet

Answer 22

Platelet Clot

Question 23

Autosomal
dominant

Answer 23

vWF disease
Quebec platelet
Sticky Platelet
Syndrome

Question 24

Autosomal
recessive

Answer 24

-Bernard-Soulier
syndrome
-Glanzmann
thrombasthenia
-Gray platelet
syndrome
-Thrombocytopenia absent radius (TAR)
syndrome
-Hermansky-Pudlak
syndrome

Question 25

X-linked

Answer 25

Wiskott-Aldrich syndrome Scott syndrome

Question 26

no aggregation with natural agonists - Because there is qualitative or quantitative defect of GP αIIbβ3

Answer 26

Glanzmann thrombasthenia (Abnormal Clot retraction)

Question 27

decreased Thrombin generation - Because phosphatidylserine cannot translocate to the outer layer

Answer 27

scott

Question 28

lack of adhesion to VWF and abnormal response to thrombin - Deficiency or mutation on GP: IX, Ibβ, and Ibα

Answer 28

Bernard-Soulier syndrome

Question 29

spontaneous binding of VWF to GP Ibα - Result of binding: they are removed from the circulation

Answer 29

Platelet-type VWD (Type 2B)

Question 30

Gray Platelet Syndrome Quebec Platelet Disorder α-Dense granule-storage pool deficiency Wiskott-Aldrich Syndrome

Answer 30

α-Granules

Question 31

G-proteins Phospholipases

Answer 31

Signaling pathways

Question 32

Hermansky-Pudlak syndrome Chediak-Higashi syndrome Dense granule-storage pool deficiency Wiskott-Aldrich Syndrome

Answer 32

Dense granules

Question 33

Cyclooxygenase TXA2 synthase Lipoxygenase (Drug induced)

Answer 33

Enzymes in dense tubular system

Question 34

Giant Platelet syndromes ● Large platelets Wiskott-Aldrich syndrome ● Micro Platelets or micro thrombocytes formation

Answer 34

Cytoskeleton