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Flashcards in main points of biochem Deck (14):
1

pt with

garlic breath

vomiting 

rice water stools

QT prolongation

arsenic poisoning. 

arsenic inhibits lipoic acid. which is needed for pyruvate dehydrogenase complex.

2

tx for

pyruvate dehydrogenase def

 

ketogenic amino acids 

(**Lysine, leucine)

vit supplementation if its caused by 

vit B def (thiamine)

 

"Lysine and Leucine - the onLy pureLy ketogenic AA)

3

what is the rate limiting enzyme for TCA cycle

Isocitrate dehydrogenase 

isocitrate --> a-ketoglutarate

4

what are the 3 key enzymes you need to know for TCA cycle?

citrate synthase

isocitrate dehydrogenase

a-ketoglutarate dehydrogenase

5

what 4 end products can be made from pyruvate

oxaloacetate

lactate

acetyl-CoA

Alanine

6

what 4 B vitamins are needed to make cofactor for pyruvate dehydrogenase

B1 (thiamine) --> TTP

B2 (riboflavin) --> FAD+

B3 (niacin) --> NAD+

B5 (pantothenic acid) --> Co enzyme A

7

cause of 

familial hypercholesteralemia

def of

LDL receptors

8

which apolipoprotein matches the statement

 

activates LCAT

ApoA-1

9

which apolipoprotein matches the statement?

 

mediates Chylomicron secretion

ApoB-48

10

which apolipoprotein matches the statement

mediates VLDL secretion

ApoB-100

11

which apolipoprotein matches the statement

 

cofactor for lipoprotein lipase

ApoC-II

12

which apolipoprotein matches the statement

mediates uptake of remnant particles 

ApoE

13

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