main points of biochem Flashcards
pt with
garlic breath
vomiting
rice water stools
QT prolongation
arsenic poisoning.
arsenic inhibits lipoic acid. which is needed for pyruvate dehydrogenase complex.
tx for
pyruvate dehydrogenase def
ketogenic amino acids
(**Lysine, leucine)
vit supplementation if its caused by
vit B def (thiamine)
“Lysine and Leucine - the onLy pureLy ketogenic AA)
what is the rate limiting enzyme for TCA cycle
Isocitrate dehydrogenase
isocitrate –> a-ketoglutarate
what are the 3 key enzymes you need to know for TCA cycle?
citrate synthase
isocitrate dehydrogenase
a-ketoglutarate dehydrogenase
what 4 end products can be made from pyruvate
oxaloacetate
lactate
acetyl-CoA
Alanine
what 4 B vitamins are needed to make cofactor for pyruvate dehydrogenase
B1 (thiamine) –> TTP
B2 (riboflavin) –> FAD+
B3 (niacin) –> NAD+
B5 (pantothenic acid) –> Co enzyme A
cause of
familial hypercholesteralemia
def of
LDL receptors
which apolipoprotein matches the statement
activates LCAT
ApoA-1
which apolipoprotein matches the statement?
mediates Chylomicron secretion
ApoB-48
which apolipoprotein matches the statement
mediates VLDL secretion
ApoB-100
which apolipoprotein matches the statement
cofactor for lipoprotein lipase
ApoC-II
which apolipoprotein matches the statement
mediates uptake of remnant particles
ApoE
