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Flashcards in Major Cytokines Deck (31)
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Interferons

Interfere with viral replication

-IFN-alpha, IFN-beta, IFN-gamma

1

G-CSF

Granulocytes hematopoeisis

2

M-CSF

Macrophage hematopoeisis

3

SCF

Differentiation of BM cells

4

GM-CSF

Granulocyte/macrophage hematopoeisis

5

IL-3

Hematopoeisis

6

IL-6

Hematopoeisis

7

IL-7

Hematopoeisis
-bcells/tcells

8

IL-11

Hematopoeisis, platelets

9

IL-5

Hematopoeisis for eosinophils

10

TNF-alpha

Induces fever, pro inflammatory

11

TNF-beta

Lymphotoxin, proinflammatory

12

RANTES

Chemokine

13

Eotaxin

Chemokine - eosinophil specific

14

IL-8

Chemokine (CXCL8)

15

SDF-1

Chemokine

17

IL-12

Drives TH1 formation from th0

18

IL-17

Drives inflammation

19

Bacterial septic shock & TSS

Overproduction of IL-1 & TNF-Alpha

20

IL-4

Induces th0 to form th2

21

Th1, TNF-B, IFN-gamma

Act on macrophages to induce cell mediated immunity

22

Th2, IL-4, IL-5, IL-13

Act on b-cells to induce antibody mediated immunity

23

IFN-alpha cytokine therapy

Hepatitis b, hep c, hairy cell leukemia, chronic myelogenous leukemia

24

IFN-B cytokine therapy

Multiple sclerosis

25

IFN-gamma cytokine therapy

Chronic granulomatous disease

26

IL-13

Anti inflammatory

27

IL-17

Inflammatory

28

IL-23

Generation of T-reg

29

TGF

Anti-inflammatory

30

IL-1

Inflammatory