malaria Flashcards Preview

unit 2 pharm > malaria > Flashcards

Flashcards in malaria Deck (10):
1

Quinoline Derivatives

  • Chloroquine, Mefloquine, Quinidine and Quinine
  • accumulate in parasite's food vacuole and disrupt heme polymerization to hemozoin --> oxidative damage to membrane and digestive proteases
  • prophylaxis and treatment of acute attacks

 

intracellular compartments of parasite become progressively more acidic --> drug gets trapped in protonated form in food vacuole

2

Primaquine

  • Quinolone derivative
  • only drug that inhibits exoerythrocitic schyzogony
  • don't give to patients with G6PD defiency!
  • drug oxidizes glutathione and G6PD replenishes reduced glutathione

3

Pyrimethamine, Chloroguanide (Progaunil)

  • inhibit dihydrofolate reductase
  • used in combo with Atovaquone

4

Atovaquone

  • depolarizes parasitic mitochondria and inhibits their electon transport (low incidence of resistance)
  • used in combo with Proguanil

5

Artemisinin Compounds

  • Artemether and Artesunate
  • inhibits SERCA of P. falciparum

**think artemiSinin = Serca

only works for P. falciparum!!

6

tetracycline, clindamycin, doxycycline

used to treat severe malaria, and uncomplicated chloriquine-resistant malaria

7

only strains that demonstrate chloroquine resistance

  • P. falciparum and P. vivax

8

chloroquine resistant P. falciparum

atavaquone and chloroguanide

9

chloroquine resistant vivax

Quinine and Primaquine + antibiotic

10

vivax and ovale chloroquine sensitive

chloroquine and primaquine (only vivax and ovale have hepatic stages)