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Conditions: Infection > Malaria > Flashcards

Flashcards in Malaria Deck (20):
1

What are the 5 causes of human plasmodium infection?

Plasmodium falciparum
Plasmodium ovale
Plasmodium vivax
Plasmodium malariae
Plasmodium knowlesi

2

Where in the world is falciparum most common?

Sub saharan africa

3

Where in the world is vivax most common?

IS THE MOST COMMON
But asia lmao

4

What mosquitos spread malaria?

Female anopheles

5

What are the phases of the plasmodium lifestyle that are considered the pre-patent period?

Asymptomatic phase

Sporozoites entering hepatocytes and performing asexual reproduction

6

How long is the pre patent phase for falciparum?

7 - 30 days

7

What point in the life cycle does the pre patent phase end?

Merozoites released into blood

Infect erythrocytes

8

What do the merozoites become in erythrocytes?

Trophozoites

9

What do trophozoites cause?

Erythrocyte rupture --> release of more merozoites

10

What happens when the erythrocyte fragments are detected by the immune system?

Cytokine release

11

What do some trophozoites become?

Gametozoites

12

What can gametozoites do?

Sexual reproduction and be transmitted back to mosquitos

13

Symptoms of malaria?

Fever
Myalgia
Headache
Anorexia
Anaemia

14

Gold standard diagnostic treatment?

Giemsa stain

15

What tests can be done in rural areas?

Rapid diagnostic test in 15 minutes but lots of false positives

16

FBC findings?

Thrombocytopenia
Hypoglycaemia

17

Treatment of uncomplicated malaria?

Chloroquine/hydroxychloroquine

18

What can you add with chloroquine/hydroxychloroquine for ovale and vivax infection in uncomplicated malaria?

Primaquine

19

What is the treatment for severe P.Falc infection?

IV quinine
IV doxycycline

20

What prevention methods exist for malaria?

Nets
Prophylactic chemo
- Chloroquinine
- Doxycycline