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NAPLEX BABY > Male & Female Health > Flashcards

Male & Female Health Flashcards

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1
Q

FDA rule with hormonal contraceptives

A

requires dispensing with patient package insert with ALL oral contraceptives

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2
Q

Drospirenone

A

a unique progestin, it is a mild potassium-sparing diuretic with lower androgenic activity = less bloating, weight gain, PMS symptoms, acne

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3
Q

Progestin-Only Pills (Mini-Pills)

A

28 day pack (all pills are active)

Primary uses:
–> women who are breastfeeding (estrogen dec milk production)
–> women who have migraines with aura (estrogen increases the risk of stroke)

*Adherence is essentail!
-take at the same time of day, daily
-id > 3 hrs have elapsed from the regularly scheduled time, a back up contraceptive is required for 48 hrs

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4
Q

Non-oral Hormonal Contraceptives

A

-Xulane contraceptive patch: higher estrogen exposure, less effective in women > 198 lb
-Vaginal contraceptive rings: inserted into the vagina once a month
-Injectable contraception: Depo-Provera (medroxyprogesterone acetate, DMPA), IM or SC q 3 months
-Intrauterine devices (IUDs): long acting

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5
Q

COCs: Seasonique

A

-extended cycle COC that has 84 days (12 weeks) of active hormone pills, bleeding occurs every 3 months
–> 84 days of EE and levonorgestral (LNG)

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6
Q

COCs: Amethyst

A

-continuous contraception, no inactive pills; no periods occur
–> 28 days of EE + LNG with no placebo pills

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7
Q

Contraceptive types/naming tips *

A

Lo: <35 mcg of estrogen (Loestrin)

Fe: includes an iron supplement (Junel Fe)

24: shorter placebo time, 24 active + 4 inactive (or Fe) pills (Minastrin 24 Fe)

Tri or 7/7/7: 3 diff hormone strengths for each “phase” or week (Tri-Sprintec, Nortrel 7/7/7)

Nor: contained the progestin norethindrone (Nora-BE)

Pro: contains a progestin (Depo-Provera)

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8
Q

AEs of hormonal contraceptives: Estrogen*

A

-Common and nonspecific: nausea, breast tenderness/fullness, bloating, weight gain, elevated BP (lower estrogen = less side effects but more breakthrough bleeding)

SEVERE & RARE:
-Abdominal pain (mesenteric or pelvic vein thrombosis)
-Chest pain (heart attack or pulmonary embolism
-Headaches (stroke)
-Eye problems (vision loss due to blood clot in the eye)
-Swelling (deep vein thrombosis)

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9
Q

AEs of hormonal contraceptives: progestin

A

late cycle breakthrough bleeding?
–> a higher dose of progestin needed

Drospirenone-containing products:
–> increased clotting risk, K+ retention

Depo-Provera:
–> bone density loss - take adequate calcium and vitamin D

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10
Q

Adverse effects of hormonal contraceptives: BBWs*

A

A. all estrogen containing products: do not use in women > 35 y/o who smoke due to risk of serious cardio events

B. Estrogen + Progestin patches (Xulane, Zafemy, Twirla): do not use in women with BMI > 30 due to increased risk of thromboembolism or decreased efficacy (T)

–> do NOT use estrogen with these conditions: hx of CVT/PE, stroke, CAD, hx of breast, ovarian, or liver cancer or migraines with aura

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11
Q

Considerations for drug selection: POP or non-hormonal method

A

-breastfeeding
-3-6 weeks postpartum
-CI to estrogen
-migraine w/ aura
-uncontrolled BP

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12
Q

Considerations for Drug selection: Drospirenone-Containing products

A

-acne
-fluid retention/bloating
-mood changes or disorder
-premenstrual dysphoric disorder (YAZ)

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13
Q

Considerations for drug selection: others

A

-mood changes or disorders: use mono phasic, extended or continuous style COCs (wont have changes in hormone levels)

-menorrhagia (heavy bleeding): Natazia or Mirena IUD

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14
Q

Drugs that decrease hormonal contraception efficacy

A

Strong inducers:
-Rifampin (requires a back up method for 6 weeks after d/c)
-Anticonvulsants (phenytoin, carbamazepine, topiramate)
-St. John’s wort
-Tobacco

Risk with hep C tx: Mavyret (liver toxicity)

Drospirenone: inc potassium risk

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15
Q

Starting BC pills

A

Combo Oral Contraception:
-takes ~ 7 days of tx to achieve efficacy (requires 7 days of non hormonal method)
-start today: maximizes protection from unintended pregnancy
-Sunday start: start the Sunday after onset of menstruation

Progestin-Only Pills:
-takes 48 hrs to achieve efficacy (use back up method for 48 hrs)
-start at any time, all come in 28 days packs and all pills are active

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16
Q

Instructions for late or missed Hormonal Contraceptive Pills

A

COCs:
–> 1 late or missed pill (< 48hrs): take missed pill ASAP & take next dose on schedule (even if it means 2 pills in 1 day)
-NO EC or back up method needed

–> 2 missed pills (> 48 hrs): take the most recent missed pill (discard the rest of missed pills), take the next dose as scheduled
- if missed 2 or more pills during week 3: omit hormone free week and start next pack
-back up contraception needed for 7 days, can consider EC if unprotected sex in last 5 days

POPS:
–> if > 3 hrs past scheduled time: take pill ASAP and take next dose on schedule
-back up method needed for 48 hrs, consider EC if unprotected sex in past 5 days

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17
Q

Long acting reversible contraceptives

A

IUDS: contain levonorgestrel
–> Mirena: inserted for up to 5 yrs, approved fro heavy menses
–> Skyla: inserted for up to 3 yrs
–> Paragard: copper-T IUD, inserted for up to 10 yrs, can be used for EC or regular BC

Implant:
–> Nexplanon: rod SC that releases estongesterel for 3 yrs

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18
Q

Emergency Contraception (EC)

A

A. Paraguard IUD: 99.9% effective, use within 5 days, placed by provider, good for up to 10 yrs

B. Ullipristal (Ella): less effective if > 195 lbs or BMI > 30, use ASAP or within 5 days. RX required, take after every episode of unprotected sex
–> 30 mg dose, taken up to 5 days, delays ovulation (chemical cousin to mifepristone - Ella is lower potency)

C. Levonorgestrel (Plan B): less effective if > 165 lb or BMI > 25, use ASAP or within 3 days, available OTC, use after every episode of unprotected sex
–> LGN 1.5 mg PO x 1 take within 72 hrs of sex (vomit within 2 hrs, repeat dose)

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19
Q

Infertility drugs*

A

-not being able to reproduce after 1 yr of sex
1st line: Clomiphene (SERM): ses- hot flashes, thrombosis
2nd line: gonadotropin : SC or IM

-inc LH/FSH = ovualtion/egg release
–> Clomiphene acts as estrogen to inc LH/FSH = causes ovulation
–> aromatase inhibitors suppress. estrogen to in FSH = causes ovulation
–> Gonadotropin durgs act as LH, FSH, or hcG = causes ovulation

Pros:
-infertility drugs trigger ovulation
-they can trigger the release of multiple eggs and inc risk of multiple births

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20
Q

Vitamin and Mineral supps in pregnancy

A

-vitamin D 600 IU/day
-folic acid 600 mcg/day (400 mcg daily for adults)
-calcium 1,000 mg/day

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21
Q

Immunizations in preganacy*

A

-Influenza vaccine (inactivated)
-Tdap x1 with each pregnancy (between weeks 27 and 36)
-live vaccines are CI

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22
Q

Teratogens: Danger in Pregnancy*

A

-Acne: Isotretinoin, topical retinoids
-Antibiotics: quinolones, tetracyclines
-Anticoagulants: Warfarin
-Dyslipidemia,HP,HTN: Statins, RAAS inhibitors, ARBs, aliskiren, valsartan
-Hormones: estrodial, progesterone, raloxifene, Duavee, testosterone, contraceptives
-Migrains: Dihydroergotamine, ergotamine
-Others: hydroxyurea, lithium, methotrexate, missoprostol, NSAIDs, Paroxetine, Ribavirin, Thalidomide, Topiramate, weight loss drugs, valproic acid, Divalproex

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23
Q

Management during pregnancy: Morning Sickness

A

1) lifestyle: eat smaller, more frequent meals, avoid spicy foods
2) vitamin B6 (pyridoxine) +/- doxylamine
RX: Bonjesta, Diclegis
-Doxylamine (Unisom) 25 mg tab
-Pyridoxine (B6) 25 mg daily 2-4 x daily

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24
Q

Management during pregnancy: Heartburn, Constipation, Gas

A

H: small meals, avoid trigger foods, calcium antacids (TUMs)

Gas: Simethicone (Gas-x, Mylican)

Constipation: inc dietary fiber, water, exercise, bulk forming laxatives (Metamucil, Fibercon), docusate

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25
Management during pregnancy: Cough, Cold and Allergies
1st line: Cromolyn 2nd line: 1st gen antihistamines (Chlopheniramine - preferred, diphenhydramine) --> if nasal steroids are needed: Budesonide (Rhinocort Allergy) or beclomethasone (Beconase AQ)
26
Management during pregnancy: Pain
acetaminophen is 1st line **DO NOT use NSAIDs, especially in 3rd trimester
27
Management during pregnancy: Asthma, Anemia
Asthma: maintain control! - budesonide (Respules for baby), albuterol if needed Anemia: Iron
28
Management during pregnancy: Hypertension and Diabetes
HTN: labetalol, methyldopa, nifedipine (low dose aspirin is rec for preeclampsia in high risk groups) Diabetes: Insulin is the drug of choice (glyburide and metformin are used), screen for gestatinal DM, dietary modifications -ADA: daily low dose aspirin for pregos w/ type 1 and type 2 dm to lower the risk of preeclampsia
29
Management during pregnancy: Infections
SAFE: penicillins, cephalosporins, erythromycin, azithromycin AVOID: Quinolones (cartilage damage), tetracyclines (tooth discoloration) --> vaginal fungal infections: topical antifungals x 7d --> UTI: -cephalexin 500 mg q6h x7d -ampicillin 500 mg Qy6h x7d (nitro & bactrim: should be considered LAST line during 1st trimester, and SHOULD NOT BE used in the last 2 weeks of pregnancy) *must treat bacteriuria, even if asymptomatic w/ neg urinalysis; leads to premature birth, pyelonephritis and neonatal meningitis
30
Management during pregnancy: Anticoagulation & Thyroid Disorders
Anticoagulation: Low molecular weight heparin -mechanical valve: LMWH, can go back to warfarin after 13th week of pregnancy, then back to LMH close to delivery Hypothyroidism: Levothyroxine- needs a 30-50% dose INCREASE Hyperthyroidism: ideal to normalize before pregnancy -1st trimester: propythiouracil (PTU)** -2nd and 3rd trimester: Methimazole ** **liver toxicity, crosses placenta & can cause congenital defects
31
Lactation
-breastfed bbys need 400 IU of vitamin D daily -need 1 mg/kg daily of iron during months 4-6 DRUGS TO AVOID: amphetamines, aminodarone, ergotamines, lithium, metronidazole, phenobarbital and statins --> HIV + females: breastfeeding is NOT recommended -drugs for lactation resources: Lactmed, Briggs, Hales
32
Treating pain during breast feeding
DO NOT use codeine and tramadol: risk of excessive sleepiness, breathing diffculty and/or death --> breastfed infant have died, esp in mothers who were CYP2D6 ultra-rapid metabolizers
33
Select factors conditions with Osteoporosis Risk*
-Patient characteristics: advanced age, ethnicity *white and asian women are at inc risk), family hx, gender (females), low body weight -Medical Diseases/Conditions: anorexia, DM, Gi diseases (IBD, celiac disease, gastric bypass), hyperthyroidism, hypogonadism in men, menopause, RA, epilepsy, HIV/AIDS, Parkinson's Disease -Lifestyle Factors: smoking, excessive alcohol intake (> 3 drinks/day), low calcium intake, low vit D intake, physical inactivity -Medications: anticonvulsants (carbamazepine, phenytoin, phenobarbital), aromatase inhibitors (letrozole), GnRH agonists, lithium, PPIs (dec calcium), steroids (> 5 mg daily for > 3 months), thyroid hormones, heparin, loop diuretics, SSRIs, TZDs
34
Diagnosis of Osteoporosis*
What is a T-score? --> compares the pts measured BMD to the average peak BMD of a healthy, young, white adult of the same sex -a DEXA (DXA) measured BMD so a T-score can be determined (T-scores are neg, > -1 = denser bones Who should have BMD measured? --> women > 65 y/o --> men > 70 y/o --> younger pts at high risk for fracture Interpreting T-score Results: --> normal = > -1 --> Osteopenia (low bone mass): -1 to -2.4 --> Osteoporosis: < - 2.5
35
Prevention of OS: calcium and Vit D supplementation *
CALCIUM: rec daily intake: 1,000-1,200 mg of elemental ca daily (do not exceed 500-600 mg/dose) --> Calcium Carbonate (TUMs): 40% elemental CA, acid dependent absorption, must take w/ meals --> Calcium Citrate (Citarcal): 21% elemental Ca, not acid dependent, can take w/ or w/o food VITAMIN D: required for Ca absorption, 600 IU daily -deficiency = serum Vit D (25(oh)D) < 30 ng/ml --> Cholecalciferal (D3) 125-175 mcg daily OR --> Ergocalciferl (D2) 1,250 mg weekly
36
*Osteoporosis treatment: Bisphosphonates
1st line for tx and prevention - stops osteoclasts (bone breakdown) -Alendronate (Fosamax) PO weekly -Ibandronate (Bonvia) monthly PO, IV q 3 mon -Zoledronic acid (Reclast) IV q year -take 1st thing in the am before you eat or drink w/ full glass of water, must sit or stand upright for 30 mins (60 mins w/ Ibandronate (Boniva)) and do not eat or drink SE: esophagitis, hypocalcemia, GI effects, bone pain Rare SEs: atypical femur fractures, osteonecrosis of the jaw -has PO given weekly or monthly, IV (Zoledronic acid (Reclast)) - IV once yearly *treatment duration is 3-5 yrs
37
*Osteoporosis treatment: Estrogen Antagonist-Antagonist Containing products
-alt to bisphosphonates if high risk of vertebral fractures --> both increase risk of VTE and stroke Raloxifine (Evista): SERM, can be used if low VTE risk or high breast cancer risk, d/c at least 72 hrs prior and during surgery or w/ prolonged bed rest -SEs: vasomotor symptoms Bazedoxifene/Estrogen (Duavee): can be used in women w/ an intact uterus for prevention -SEs: inc risk of breast cancer
38
*Osteoporosis treatment: Parathyroid Hormone 1-34
-Teriparatide (Forteo) inj- requires protection from light -Abaloparatide (Tymlost) recommended for very high risk pts only -daily SC -SEs: hypercalcemia, urinary stones, bone cancer, leg cramps,
39
*Osteoporosis treatment: Denosumab (Prolia)
-alt to bisphosphonates -SC admin every 6 months SE: hypocalcemia
40
*Osteoporosis treatment: last line or not recommended
-estrogen (with or w/o progestin) fro prevention only in postmenopausal women with vasomotor symptoms: use lowest possible dose for shortest duration of time -calcitonin for tx only if other options are not suitable (less effective and has a risk of cancer with long term use)
41
*Menopause hormone therapy: Estrogens
-most effective tx for vasomotor symptoms: use topicals when you can -women w/ a uterus use in combo with a form of progesterone; unopposed estrogen increases the risk of endometrial cancer -associated with significant safety risks: BBW for VTE, stroke, dementia and breast cancer
42
*Menopause hormone therapy: Progestin
-Progestins (norethindrone, levonorgesterol, drospirenone) can be given as part of combo pill w/ estrogen or as a separate tab (MPA) -can cause mood disturbances, spotting -micronized progestins (Premetrium) are considered safer than synthetic progestins (medroxyprogesterone)
43
*Menopause hormone therapy criteria
-healthy, symptomatic women who are within 10yrs of menopause, < 60 y/o and have no CI to use -extended tx beyond age 60 may be acceptable if the loest poss dose is used -pts with risk factors (age, time since menopause, risk of blood clots, heart disease, stroke and breast cancer) should use nonhormonal options: SSRIs, SNRIs, gabapentin or pregabalin
44
Other products for menopause
Natural products: black cohosh, red clover, soy, flaxseed, dong quai, st. johns wort and evening primrose oil SSRIs: Paroxetine (CYP2D6 inhibitor, bleeding risk) -Osphemifene (Osphena): oral estrogen agonsits/antagosnit for painful intercoutse (dyspareunia) - VTE risk
45
Testosterone BBWs- C-III
-reports of virilization of children d/t testosterone exposure (androgel- daily application on shoulders) -breast/prostate cancer risk -BPH symptoms would be expected to worsen w/ testosterone tx SEs: inc appetite, acne, edema, hepatotoxicity, reduced sperm count
46
Natural products for ED
-Yohimbe (GI, anxiety, CVD effects) -L-argninine (dizziness, HA & flushing) -Panax Ginseng
47
Drug that can cause erectile dysfunction*
-alcohol -antidepressants: SSRI/SNRIs -antihypertensives: BBs, clonidine, thiazides -antipsychotics: 1st gen (chlorpromazine), risperidone, paliperidone -BPH meds: finesteride, dutasteride and sildosin -nicotine -cimetidine -opioids (chronic use- methadone)
48
PDE-5 inhibitors for ED
-sildenafil (Viagra) -also used for PAH, 1 hr before sex -vardenafil (Levitra), 1 hr before sex -tadalafil (Cialis) - also used for PAH, 30 mins before sex -Avanafil (Stendra)- take 15-30 mins before sex CI: use with nitrates ("nitr" in the name, bidil) Warnings: impaired color discrimination, hearing loss, vision loss, hypotension, priapism SE: HA, flushing, dizziness, dyspepsia
49
PDE-5 inhibitor dosing guide*
reduce dose if: > 65 y/o, using an alpha blocker (doxazisin, tamsulosin), using a CYP3A4 inhibitor, severe renal or liver damage -Viagra - blue 50 mg --> 25 mg -Cialis (brown), Levitra (orange): 10 mg --> 5 mg -Stendra (yellow): 100 mg --> 50 mg
50
Alprostadil (Prostaglandin E1) for ED
-shot or pellet urethral suppository SEs: penile pain, priapism, HA, dizziness pp shot SE: hematoma, bruising at injection site
51
Hypoactive sexual desire disorder
poss causes: menstrual cycle, hormonal contraceptives, postpartum states and lactation, oophorectomy and hysterectomy, menopause things --> Fibanserin (Addyl): CI: w/ alcohol (REMS) Warnings: hypotension, syncope, CNS depression SEs: dizziness, somnolence, nausea, fatigue, dry mouth (not effective, bad effects)
52
Key drugs that can worsen BPH *
-anticholinergics (benztropine) -antihistamines (Diphenhydramine) -caffeine -decongestants (pseudoephedrine) -diuretics -SNRIs -TCAs (amitriptyline) -testosterone products Diagnosis: digital rectal exam + prostate specific antigen
53
BPH drug treatment: Alpha Blockers
--> Non-selective: terazosin, doxazosin (Cardura) -tirate slowly, give at bedtime --> Selective: Tamsulosin (Flomax): 0.4 mg daily, Alfuzosin- QT prolongation, Silodosin: retrograde ejaculation CI: hepatic and renal impairment Warnings: orthostatic hypotension/syncope, intraoperative floppy iris syndrome can occur in cataract surgery if on or previously used SE: dizziness, fatigue, headache, abnormal ejaculation
54
BPH tx: 5 Alpha-reductase Inhibitors
shrink the prostate and decrease PSA levels -Finasteride (Proscar) -Dutasteride (avodart) + tamsulosin (Jalyn) SEs: impotence, libido, breast enlargement/tenderness -hazardous drug
55
Risk factors for overactive bladder
-age > 40 -DM -prior vaginal delivery -obesity -neurological conditions -drugs that increase incontinence (alcohol, cholinesterase inhibitors, diuretics, sedatives)
56
Anticholinergics used for overactive Bladder
-Oxybutynin -Oxybutinin XL (Ditropan) -Oxybutynin patch (Oxytrol) -Oxybutynin 10% topical cream -Soliifenacin (VESIcare) -Tolterodine (Detrol)
57
Anticholinergics safety/SEs/Monitoring
CI: uncontrolled narrow angle glaucoma Warnings: agitation, confusion, drowsiness, dizziness, blurred vision SEs: dizziness and drowsiness, xerostomia, constipation Notes: --> Ditropan XL is OROS formulation = ghost shell in stool
58
Patches to be removed before an MRI*
-Clonidine (Catapres-TTS) -Diclofenac (Flector) -Estrogen -Rotigotine (Neupro) -Scopolamine (Transderm Scop) -Testosterone (Androderm)
59
Anticholinergic Side effects *
Peripheral: -Dry mouth -Dry eyes/blurred vision -Urinary retention -Constipation -Tachycardia Central: -Sedation -Dizziness -Cognitive impairment
60
Decreasing risk of dry mouth w/ anticholinergics *
-extended release formulations -oxybutynin gel or patch -beta 3 agonists have a lower incidence of dry mouth and can be helpful in pts who cannot tolerate anticholinergics -non drug options: avoid mouthwashes with alcohol, use ice chips, water, sugar-free candy or gum
61
Beta-3 Agonist for Overactive Bladder
-Mirabegron (Myrbetriq) -Vibegron (Gemtesa) --> relax the detrusor muscle + increase bladder capacity by activating beta-3 receptors (less dry mouth) SEs: hypertension, angioedema of face/lips/mouth -effective within 8 weeks -moderate inhibitor of CYP2D6
62
Last line tx for Overactive Bladder
-Onabotulinumtoxin A (Botox) Dose: 100 units total over 20 sites, max Q3 months SEs: UTIs, urinary retention, dysuria --> requires ab before and after administration
63
Nocturia Treatment for adults
Desmopressin (DDAVP) -antidiuretic hormone that temporarily decreases urine production BBW: hyponatremia

NAPLEX BABY (23 decks)

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