Male Sex Hormones & Their Antagonists

Question 1

What are the main indications for Androgens (Testosterone, Mesterolone)?

Answer 1

Testosterone replacement therapy for hypogonadism (low testosterone).
Mesterolone used in male infertility due to low androgen levels.

Question 2

What are the cautions when using Androgens (Testosterone, Mesterolone)?

Answer 2

Monitor for cardiovascular risks (hypertension, heart disease).
Risk of prostate enlargement or cancer progression.
May affect liver function and blood clotting.

Question 3

What are the contraindications for Androgens (Testosterone, Mesterolone)?

Answer 3

Prostate or breast cancer in men.
Severe liver or kidney disease.
High red blood cell count (polycythaemia).

Question 4

What are the common side effects of Androgens (Testosterone, Mesterolone)?

Answer 4

Acne, fluid retention, mood changes.
Increased red blood cell count (risk of clots).
Gynecomastia (breast enlargement) due to oestrogen conversion.

Question 5

What are the available forms of Androgens (Testosterone, Mesterolone)?

Answer 5

Oral (mesterolone).
Buccal (testosterone tablets).
Intramuscular (IM) injections (testosterone enanthate, undecanoate).
Transdermal (patches, gels).

Question 6

What are the main indications for Antiandrogens (Dutasteride, Finasteride)?

Answer 6

Benign Prostatic Hyperplasia (BPH) (to reduce prostate size and improve urination).
Androgenic alopecia (male pattern baldness) (finasteride).

Question 7

What are the cautions when using Antiandrogens (Dutasteride, Finasteride)?

Answer 7

Can cause sexual dysfunction (reduced libido, erectile dysfunction).
May lower PSA levels, masking prostate cancer diagnosis.
Dutasteride has a long half-life (takes months to clear).

Question 8

What are the contraindications for Antiandrogens (Dutasteride, Finasteride)?

Answer 8

Women of childbearing age (teratogenic effects on male fetuses).
Severe liver impairment

Question 9

What are the common side effects of Antiandrogens (Dutasteride, Finasteride)?

Answer 9

Reduced libido, erectile dysfunction, ejaculation disorders.
Breast tenderness/enlargement.
Depression and mood changes.

Question 10

What are the available forms of Antiandrogens (Dutasteride, Finasteride)?

Answer 10

Oral tablets/capsules (dutasteride, finasteride).