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Male Sex Steroids (Androgens) Flashcards

(6 cards)

1
Q

Describe Testicular Anatomy?

A

a. LH → Leydigcells → testosterone → (negativefeedbackonhypothalamus) → inhibition of GnRH release.
b. GH is synergistic with LH to increase the synthesis of testosterone

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2
Q

What increases Sex-Hormone binding globulin(SHBG)?

A

estrogen, thyroid hormone, pts with cirrhosis

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3
Q

What decreases Sex-Hormone binding globulin(SHBG)?

A

androgen and growth hormone, and in obese pts.

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4
Q

What is Androgen Binding Protein (ABP)?

A

i. Similar in structure to SHBG
ii. Binds testosterone in order to keep its intratesticular levels high
iii. FSH → Sertoli Cells → production of ABP

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5
Q

What is the metabolism of testosterone?

A

Testosterone in liver → androstenedione → andosterone

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6
Q

Which are the Synthetic Androgens that can be used orally?

A
Methyltestosterone
Fluoxymesterone (has intrinsic aromatase –blocking activity)
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