Male Sex Steroids (Androgens) Flashcards
(6 cards)
1
Q
Describe Testicular Anatomy?
A
a. LH → Leydigcells → testosterone → (negativefeedbackonhypothalamus) → inhibition of GnRH release.
b. GH is synergistic with LH to increase the synthesis of testosterone
2
Q
What increases Sex-Hormone binding globulin(SHBG)?
A
estrogen, thyroid hormone, pts with cirrhosis
3
Q
What decreases Sex-Hormone binding globulin(SHBG)?
A
androgen and growth hormone, and in obese pts.
4
Q
What is Androgen Binding Protein (ABP)?
A
i. Similar in structure to SHBG
ii. Binds testosterone in order to keep its intratesticular levels high
iii. FSH → Sertoli Cells → production of ABP
5
Q
What is the metabolism of testosterone?
A
Testosterone in liver → androstenedione → andosterone
6
Q
Which are the Synthetic Androgens that can be used orally?
A
Methyltestosterone Fluoxymesterone (has intrinsic aromatase –blocking activity)
