Management of Depressive Mood Disorders Flashcards

(49 cards)

1
Q

What is the DSM diagnostic criteria for diagnosing Major Depression

A

Pt must have 5/9 of the symptoms for at least 2 weeks, and one of them MUST be either: depressed mood or loss of interest or pleasure in doing things (and 4 others)

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2
Q

What are the 9 symptoms included in the major depression criteria

A
  1. Depressed mood
  2. Loss of interest or pleasure
  3. Significant change in weight or appetite
  4. Insomnia or hypersomnia
  5. Psychomotor agitation or retardation
  6. Fatigue or loss of energy
  7. Feelings of worthlessness or guilt
  8. Impaired concentration or ability to make decisions
  9. Thoughts of suicide or self harm
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3
Q

What patient population is most likely to experience symptoms of thoughts of suicide or self harm

A

Elderly are highest risk

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4
Q

What are the atypical symptoms of seasonal depression

A

A pt will experience increased appetite and increased sleep

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5
Q

What is the criteria for minor depression

A

Pt must have 2-4 of the 9 symptoms of major depression and it MUST include on of the following: depressed mood or loss of pleasure or interest

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6
Q

What does SIGECAPS stand for

A
Sleep disturbance
Interest
Guilt
Energy change
Concentration
Appetite
Psychomotor retardation or agitation
Suicidal
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7
Q

What is considered a score of severe depression on the PHQ-9

A

Score > or = to 20

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8
Q

What is considered a score of moderate/severe depression with the PHQ-9

A

15-19

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9
Q

What is considered a score of moderate depression with the PHQ-9

A

10-14

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10
Q

What is considered a score of minor depression with the PHQ-9

A

5-9

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11
Q

What is considered a normal PHQ-9 score

A

0-4

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12
Q

What are vegetative symptoms of depression

A

Vegetative symptoms of depression are physiological or are related to body function such as sleep/appetite/energy/sexual interest

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13
Q

What are the emotional symptoms of depression

A

Crying spells

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14
Q

What are the cognitive symptoms of depression

A

poor concentration

low self esteem

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15
Q

What are the treatment-resistant/depressive sub-types

A
atypical depression
double depression
psychotic depression
severe and melancholic depression
co-morbidity- psychiatric or medical
psychosocial stressors
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16
Q

How many patients with 1st depression have a 2nd depression

A

about half

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17
Q

How much does a second episode of depression increase the risk of getting a third

A

70-80%

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18
Q

How much does third depression increase the risk for a fourth

A

80-89%

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19
Q

What happens to depressive episodes with age

A

The get longer and more frequent

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20
Q

What is melancholic depression

A

Major depression with an emphasis on lack of pleasure or lack of reactivity to pleasure with three or more:

  • depressed mood worst in the morning
  • early morning awakening
  • psychomotor agitation or retardation
  • significant weight loss
  • inappropriate guilt
21
Q

What medications do melancholic depressive pts respond to best

A

TCA or Norepi reuptake inhibitors

22
Q

What are the s/s associated with melancholic depression

A
Depressed mood worst in the morning
Early morning awakening
Psychomotor agitation or retardation
Sig. WL
Inappropriate guilt
23
Q

What is required to have a dx of persistent depressive d/o

A
  • Depressed mood for most of the day, for more days than not, as indicated either by subjective account or observation of others, for at least to years and the presence of two or more of the classic depression sxs
  • During the 2 year period of the distrubance the person has never been without sx for more than 2 months at a time
  • No Major Depressive Episode has been present during the first 2 years
24
Q

What is the exception for dx persistent depressive disorder in pts that are <18 years old

A

The symptoms are only required to be persistent for 1 year, not two

25
What factors need to be considered when selecting an antidepressant
- Pts hx of response to an antidepressant/their preference - Hx of response in 1st degree relative - Cardiovascular and medical status of pt - Safety in OD if applicable - S/E - Drug interactions - Cost - does the pt have bipolar? - Does the pt need pain mgmt too? - Smoker? - Comorbities?
26
What medication has an extremely long half life
Prozac/fluoxetine
27
When prescribing an antidepressant to a pt with bipolar what should you always do
Make sure to prescribe with a mood stabilizer
28
What is a good med to RX a smoker with depression
Wellbutrin
29
What antidepressant should not be prescribed to someone who could get pregnant
Paxil
30
What antidepressants are also helpful for pain mgmt
TCAs
31
When should TCAs NOT be rxed
``` If a pt has a hx of: Ischemic heart disease Fall risks BPH Suicidal ideations ```
32
What are the uses of SSRIs
``` MDD Dysthmia (melancholic) SAD Panic d/o GAD PMDD OCD Substance Abuse Eating Disorders PTSD Premature ejaculation ```
33
What are common reasons pts d/c their antidepressants
Not being told about the s/e sexual dysfunction feeling better
34
How can you prevent initial anxiety/jitteriness that is commonly associated with initiating tx with SSRIs
Gradual titration
35
What are the important characteristics or s/e of SSRIs
- low cardiovascular effects - absence of anticholinergic activity or weight gain (except paxil) - Low OD and SZ potential - Nausea - Insomnia - Sexual Dysfxn - HA
36
What SSRI is rated D in pregnancy
paroxetine
37
What SSRI is considered the least activating
paroxetine
38
How do you prevent activation or insomnia associated with starting SSRIs
Start with tiny doses Switch to other agents Add Trazadone (for insomnia) Temporarily add clonazepam, xanax, or ambien (last choice)
39
What is a rare but serious s/e of trazodone
priapism
40
What are some tx options for sexual dysfunction associated with SSRIs
``` Yohimbine Amantadine Cyproheptadine Buspirone Buproprion Dose-Reduction Skipped Dose ```
41
What are the s/s of serotonin syndrome
``` Uncontrollable shivering Incoordination Restlessness in feet Hyperreflexia Frightened/diaphoretic/hyperarousal state Agitation Oculogyric Crisis Diarrhea Fever ```
42
What med is never recommended to mix with an SSRI and why
Triptans (can lead to serotonin syndrome)
43
What is FLUSH and what does it stand for
The sx associated with abruptly d/cing SSRIS ``` F-Flu-like symptoms L-Light headedness/dizziness U-Uneasiness S-Sleep disturbance H-HA ```
44
___________ and ____________ decreased suicidal thoughts and behavior for adult and geriatric pts
Fluoxetine/venlafaxine
45
Didn't know if we needed to know slide 34 and I am confused
Ask about attenuation in class
46
What will depression with psychotic fx increase the risk of
Suicide (by 66%) | Depressive symptoms
47
What is an additive tx that pts with depression with psychotic features should receive
Antipsychotics
48
What meds are typically less successful for depression with psychotic features
SSRIs- shouldnt be used as monotherapy
49
Left off on slide 38/44
Need to ask what the focus should be on since the last few slides were skimmed over