Marijuana

Question 1

what 3 things did ancient Egyptians use cannabis for?

Answer 1

1. glaucoma
2. inflammation
3. enemas

Question 2

THC can be administered to what 4 places

Answer 2

lung, intestine, colon, skin

Question 3

once absorbed, where does the THC concentration go?

Answer 3

extracellular water

Question 4

once in extracellular water, what 7 routes can THC take?

Answer 4

1. metabolism via liver
2. biliary excretion
3. renal excretion
4. cannabinoid receptors at site of action
5. hair, saliva, sweat
6. tissue storage (fat, protein)
7. serum protein binding lipoproteins (albumin)

Question 5

what was the first state to outlaw cannabis?

Answer 5

Massachusetts

Question 6

how many states have legal recreational cannabis use?

Answer 6

19

Question 7

how many states have legal medical cannabis use?

Answer 7

15

Question 8

what are the two receptors we have for endocannabinoids?

Answer 8

CB1 and CB2

Question 9

what G protein are CB1 and CB2 linked with?

Answer 9

Gi (inhibitory)

Question 10

where are CB1 receptors in high concentration? where are they low?

Answer 10

high: hippocampus, cortex, cerebellum, basal ganglia
low: brainstem and thalamus

Question 11

CB1 receptors in the brain are in high or low levels compared to many other brain receptors?

Answer 11

high

Question 12

where are CB2 receptors primarily located?

Answer 12

in the periphery on immune cells (has immune system functions)

Question 13

where does CB1 inhibit memory?

Answer 13

hippocampus

Question 14

what are two endogenous cannabinoids we produce in the body?

Answer 14

arachidonoulethanolamide (anandamide, AEA)
2-arachidonoylglycerol (2-AG)

Question 15

CB1 receptors are prevalent at nerve terminals in both the CNS and PNS, where they function to attenuate the release of several neurotransmitters including…
Hint: there’s 7

Answer 15

1. acetylcholine
2. dopamine
3. aminobutyric acid
4. glutamate
5. histamine
6. norepinephrine
7. serotonin

Question 16

delta 9 THC is a partial ______ for CB_ receptor in the brain and is the receptor that mediates the psychotropic effects of marijuana

Answer 16

partial agonist
CB1

Question 17

what are CB1 and CB2 receptors phosphorylated by?

Answer 17

GPCR kinases

Question 18

what are the two pathways used for cannabinoids

Answer 18

internalization and the beta-arresting pathway signaling

Question 19

CB1 receptors are expressed in the ________ ____ matter of the midbrain

Answer 19

periaqueductal gray (PAG)

Question 20

CB2 receptors are expressed primarily by ______ cells

Answer 20

immune
includes lymphocytes, monocytes, macrophages

Question 21

CB2 receptors inhibit what neuron?

Answer 21

TRPV1 in dorsal root ganglia

Question 22

what are 3 therapeutic effects of cannabis (that has substantial evidence)

Answer 22

1. treatment for chronic pain
2. N/V from chemotherapy
3. Improving multiple sclerosis spasticity symptoms

Question 23

there is limited evidence that cannabis is effective for….

Answer 23

increasing appetite and decreasing weight loss associated with HIV/AIDS

Question 24

the first strain approved in Florida was…

Answer 24

charlottes web

Question 25

CBD:THC strain of cannabis, charlottes web, reduced charlotte's seizure frequency from 50 per day to _____ per week

Answer 25

2-3

Question 26

______ is the first and only FDA-approved prescription cannabidiol (CBD). it is used for _________

Answer 26

epidiolex - for epilepsy

Question 27

Rimonabant is an ______ agonist for the CB_ receptor

Answer 27

inverse agonist CB1

Question 28

K2 or "spice" is a synthetic cannabinoid which is schedule __

Answer 28

schedule 1

Question 29

what is the feel good gene?

Answer 29

FAAH

Question 30

FAAH gene produces _________, our own natural marijuana in our brain

Answer 30

anandamide

Question 31

T or F: those with the FAAH gene mutation are less likely to become addicted to marijuana and possibly other drugs

Answer 31

true!

Question 32

those with the FAAH gene mutation have less of the enzyme ____ ______ _____ _____, which deactivates anandamide

Answer 32

fatty acid amide hydrolase

Question 33

T or F: those with the FAAH gene variant are less anxious and less inclined to like marijuana. They also have less pain

Answer 33

TRUE