marijuana Flashcards
(22 cards)
phytocannabinoids
delta 9 tetryhydrocannabinoid - dronabinol - active metabolites: cannabinol - analogues exert unique effects - metabolites exert unique effects lipid soluble
synthetic alternatives
name: K2 or spice
- affect same receptor we know marijuna does but could be different structure
stimulant and hallucinogenic properties
aminoalkylindoles
anti-inflammatory, anti-hyperalgesia
potency
hashish is more potent
more THC in hashish than marijuana
modern strains have different concentrations
dose dependant effects
light headed (buzz) - euphoric (high)- calm (stoned)
intake
inhalation- lose some THC to smoke and absorption in lungs
ingestion- lose some THC to metabolism deactivating
contact high
second hand inhalation resulting in psychoactive levels
cannabinoid as an agonist
partial agonist- endocannabinoid system
stimulating effect: motor inhibition, mood elevation, cognition, pain relief, appetite
NT in endocannabinoid
anadamide, 2-AG
behavioural effects of THC
low dose: increase motor activity decrease coordination
high dose: decrease motor activity increase reaction time
driving simulation
problem: generalizability and compensatory reactions
amotivational syndrome
lack of motivation to engage in productive activities
- no evidence for reward based strategies: opposite found
may be if self motivated or non-reward tasks
cognitive effects of THC
low dose: memory deficits with no attention impair
high dose: memory, reasoning and attention impair
diminished LTP in hippocampus
decelerated time
perception of time being slowed down
associated with stoned face- reduce blood flow to cerebellum
temporal disintegration
alteration in perceptions associated with time
flight of ideas
spontaneous seemingly random thoughts
subjectively reported as racing thoughts
executive function impairment
shown in abstinent chronic users
disorganized UWM/shift
long term effects
gateway: support for process but not likelihood of outcome, used as scare tactic
- no difference in verbal fluency and divided attention
correlated vulnerabilities
drug use accounted for by users reason for taking the drug
resident study
participants became suspicious, paranoid, agitated
- down reg of receptors
irritable when no access - appetite suppression and insomnia
cannabis dependance- substance
cannabis withdrawal syndrome- irritable/activity/anxiety
cannabinoid hyperemesis syndrome
nausea vomiting and colicky abdominal pain as a result of weekly cannabis use for years
relief: hot baths
drug discriminability
high drug discriminability
0 confound with opioids but not stimulants
