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neuropharmacology test 3 > maryam's flash card > Flashcards

maryam's flash card

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1
Q

non-selective antagonist for 5-HT2 receptor

A

mesulergine and dibenzyline

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2
Q

Maryam’s Flash card

selective antagonist for 5-HT2c

A

Ritanserin

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3
Q

Maryam’s Flash card

selective agonist for 5-HT2a

A

DMT, DOM

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4
Q

Maryam’s Flash card

selective antagonist for 5-HT2b

A

metergoline

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5
Q

Maryam’s Flash card

selective antagonist for 5-HT2a

A

ketanserin

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6
Q

Maryam’s Flash card

selective agonist for 5-HT2c

A

Agomelatine

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7
Q

Maryam’s Flash card

partial agonists for 5-HT2a

A

LSD-25 psilocybine/psilocin, pyschedetic-phenylethylamine

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8
Q

Maryam’s Flash card

migrane therapy (5-HT1b, 5-HT1d agonist)

A

Ergotamine, zolmitriptan, naratriptan, rizatriptan, sumatriptan

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9
Q

Maryam’s Flash card

G-protein for 5-HT1 receptors

A

Gi

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10
Q

Maryam’s Flash card

antagonist for all 5-HT1 receptors

A

pindolol

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11
Q

Maryam’s Flash card

selective antagonist for 5-HT1b

A

Isamoltane

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12
Q

Maryam’s Flash card

selective antagonist for 5-HT1a

A

spiperone

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13
Q

Maryam’s Flash card

selective agonist for 5-HT1b

A

Ergotamine, Sumatriptan

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14
Q

Maryam’s Flash card

selective agonist for 5-HT1a

A

buspirone

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15
Q

Maryam’s Flash card

ubiquitous agonist for all 5-HT receptor

A

serotonin, quipazine

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16
Q

Maryam’s Flash card

5-HT1d

A

autoreceptors, human neuronal

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17
Q

Maryam’s Flash card

5-HT1b

A

autoreceptors, rodent neuronal

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18
Q

Maryam’s Flash card

fenfluramine

A

blocks both vesicular SERT and cell membrane SERT

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19
Q

Maryam’s Flash card

non-selective antagonist for all B receptors

A

propranolol

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20
Q

Maryam’s Flash card

selective antagonist foe B2 receptors

A

butoxamine

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21
Q

Maryam’s Flash card

selective agonist for B2 receptor

A

albuterol, salmeterol

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22
Q

Maryam’s Flash card

selective antagonist for B1 receptor

A

atenolol

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23
Q

Maryam’s Flash card

selective agonist for B1

A

xamoterol

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24
Q

Maryam’s Flash card

non-selective agonist of B receptors

A

NE, EPI, isoproterenol, ephedrine , pseudoephdrine, clenbuterol

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25
# Maryam's Flash card non-selective antagonist for alpha-2
Yohimbine
26
# Maryam's Flash card suicide antagonist for alpha-1
Phenoxybenzamine
27
# Maryam's Flash card partial agonists for alpha-2A
LSD-25
28
# Maryam's Flash card non-selective agonist for alpha-2 receptor
NE, EPI, clonidine
29
# Maryam's Flash card alpha-2B function
Vasoconstriction
30
# Maryam's Flash card beta-Gamma subunit
inhibits VDCCs and activate CDKCs
31
# Maryam's Flash card alpha-2A function
autoreceptors
32
# Maryam's Flash card non-selective antagonist for all alpha-1 types
coryanthine
33
# Maryam's Flash card selective agonists for alpha-1A receptor
TETRAHYDRAZOLINE
34
# Maryam's Flash card non-selective antagonist for alpha receptors
phentolamine, prazosin
35
# Maryam's Flash card non-selective agonist for alpha-1 receptors
DA, NE, EPI, phenylephrine, ephedrine, pseudoephrine
36
# Maryam's Flash card MAOa and MAOb inhibitors
Iproniazid
37
# Maryam's Flash card MAOb inhibitors
deprenyl
38
# Maryam's Flash card MAOa inhibitor
befloxatone (reversible), harmaline (irreversable)
39
# Maryam's Flash card COMT-I inhibitor
tolcapone
40
# Maryam's Flash card NET reuptake inhibitor
atomoxetine, reboxetine, imipramine, amitriptyline
41
# Maryam's Flash card NET and SERT reuptake inhibitor
Venlafaxine, duloxetine
42
# Maryam's Flash card DAT, NET and SERT reuptake inhibitor
indafraline, cocaine
43
# Maryam's Flash card DAT and NET reuptake inhibitor
bupropion, nomifensine
44
# Maryam's Flash card mAch receptor agonist for M1 only
pilocarpine
45
# Maryam's Flash card mAch receptor agonist for all five types of receptors
acethylcholine, carbachol, muscarine, oxotremorine
46
# Maryam's Flash card brucine
enhance muscarinic agonist binding to Ach binding site
47
# Maryam's Flash card mAch receptor antagonist for all five types of receptors
atropine, scopolamine, cyclopentolate
48
# Maryam's Flash card antagonist for just M4
tropicamide
49
# Maryam's Flash card antagonists for M3
Aclidinium
50
# Maryam's Flash card mAch receptor antagonist for inhibitory receptors (M2, M4)
Himbacine
51
# Maryam's Flash card mAch receptor antagonist for M2 only
gallamine
52
# Maryam's Flash card mAch receptor antagonist for M1 only
pirenzepine
53
3 drugs interfere with the binding of Mg to the ATPase proton pump site
guanethedine (antihypertensive) guanadrel (antihypertensive) bretylium (blocks arrhythmias) they do not cross BBB
54
what is reuptake inhibitor for Dopamine and NE?
Nomifensin, Bupropion
55
NE reuptake inhibitors?
Atamoxetine (strattera) (are not tricyclic) (called atypicall drug) OCD/ANX/DEP Reboxetine (norebox) (are not tricyclic) (called atypicall drug) OCD/ANX/DEP Imipramine (deprenil) Tricyclic antiDEP Amitriptyline (Elavil) Tricyclic antiDEP
56
MAOa specific reversible blocker?
Befloxatone
57
MAOa specific irrevesible blocker?
Harmaline
58
MAOa or b non specific irrevesable blocker?
Iproniazid
59
MAOb sepcific irrevesable blocker?
Iproniazid
60
what is the degratory enzyme for DA, HA?
MAOb
61
what is the degratory enzyme for EN, 5-HT?
MAOa
62
Alpha 1 non-selective antagonist ?
Phentolamine Prazosin Coryanthine
63
suicide antagonist for alpha1?
Phenoxybenzamine
64
selectve agonist for Alpha1a receptors?
Tetrahydrazoline (• Eye drops – constricts blood flows in the eyes and increase blood flow) cause Dry mouth
65
non-selective agonist for alpha1 receptors?
DA NE EPI Phenylephrine Ephedrine Pseudoephedrine
66
Phenylethylamine hallucinogen relatives of NE?
* LSD-25 (partial agonist) * NE has some hallucinogenic properties * Yohimbine as hallucinogenic properties * Mescaline - partial agonists for alpha2 * Elimicin – comes from nutmeg * Ephedrine * Cathine
67
non-selectie agonist for beta 1,2,3 receptor?
NE EPI Isoproterenol Ephedrine Clenbuterol
68
selective agonist for beta1 receptors?
xamoterol
69
selective agonist for beta2 receptors?
albuterol salmeterol
70
selective antagonist for beta 2 receptor?
Butoxamine
71
selective anagonist for beta 1 receptors?
atenolol
72
non-selective antagonist for beta receptors?
propranolol
73
what is the G-protein for beta receptors?
Gs
74
what are the Vesicular Transport inhibitor?
reserpine, tetrahydrobenazine
75
what other ion are requiered for synaptic dopamin Transporter DAT? how is it blocked?
NaCl,
76
what are the Dopamin specific reuptake inhibitor?
amineptine methylphenidate amphetamine
77
what are the 2 NET and DAT reuptake inhibitor?
nomifensine, bupropion
78
Dopamin affect what kind of DA receptor?
affect all dopamin form D1 to D5 but affect D5 more
79
Apomorphine affect what kind of DA receptor?
affect D1 to D5
80
Bromocriptine affect what kind of DA receptor?
D2, D3, D4
81
pramipexole affect what kind of DA receptor?
affect 2 and 3 but has higher affinity for 3
82
Ropinirole affect what kind of DA receptor?
affect D2 and D3 but affect D3 more
83
Spiperone antagonist affect what kind DAR?
affect D1 to D5 but affect D1 and D2 more
84
Amisulpride antagonist affect what kind of DAR?
affect D2 and D3 but affect D2 more
85
Chlorpromazine antagonist affect what kind DAR? (neuroleptic)
affect D2,D3,D4
86
Trifluoperazine antagonist affect what kind of DAR?
affect D2,3,4 but more D2
87
Haloperidol antagonist affect what kind of DAR?
affect D2,3,4 but higher affinity for D2
88
Risperidone antagonist affect what kind of DAR?
affect D2,3,4 but higheraffinity for D2
89
Pimozide antagonist affect what kind of DAR?
affect D2,3,4 but affect D2 more
90
irriversable anti cholinestrase drug?
Sarin
91
long lasting anti cholinestrase?
DDT, Diazinon, Malathion
92
Vesamicol
- Drug that is often used clinically - Interferes with vesicular transporter for ACh - Binds to same site as ACh so it cannot be transported - Can cross BBB and get inside cell (very lipophilic drug)
93
inhibitory Ach receptor?
M2, M4 they act through Gi
94
excitatory Ach receptors?
M1, M3, M5 they act through Gq
95
amanita muscaria
Muscimol [GABAA] + Ibotenic acid [mGluR1,5] + muscarine
96
Differential expression of mAChRs?
* M1 expressed almost everywhere in nervous system * M3 are typically prominent in forebrain (all types of cortical structures) * M2 not as widely expressed – midbrain and brain stem * M4 are pretty common – basal ganglia and cortical areas

neuropharmacology test 3 (4 decks)

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