MCQ Flashcards

1
Q

observation that exposure to cowpox protected milkmaids from smallpox marked the beginning of

A

vaccination

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2
Q

‘immunital’ derived from

A

latin - ‘protection’

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3
Q

patient with recurrent infections - what should doctor suspect

A

immune disorder

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4
Q

we need at least two general mechanisms to fight infection: one extracellular, one intracellular

A

true

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5
Q

what is an ‘atopic’ subject

A

can over work sometimes

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6
Q

what was Jenner first to demonstrate systemically

A

that interspecies (cross) reaction could be used for protection

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7
Q

do other living organisms have an immune system

A

all have immune system

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8
Q

DNA restriction enzymes found in bacteria for

A

essential part of their immune system

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9
Q

primary purpose of immune reactions

A

defend against pathogen

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10
Q

can salt or water be haptens

A

never

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11
Q

what is a hapten

A

relatively small molecule that elicit immune response when attached to larger carrier e.g. protein

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12
Q

Gowan’s and co-workers using thoracic duct drainage where animal lymph diverted, observed test animals unable to respond to antigen challenges and failed to recognise grafts. what was function restored by

A

WBC replenishment

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13
Q

what is the primary site that supports differentiation of the I. D. stem cells

A

bone marrow - adults

liver - foetus

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14
Q

where is your thymus

A

near neck coronary arteries

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15
Q

peyers patch function

A

sampling and surveillance of Ag at intestine

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16
Q

what is considered ‘cemetery of RBC’

A

spleen

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17
Q

what is the thrombus mainly composed of

A

fibrin and platlets

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18
Q

where are albumin, fibrinolytic proteins and complement mainly synthesised in

A

liver

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19
Q

during break down of thrombus, which enzyme mainly causes fibrin degradation

A

plasmin

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20
Q

which AB isotype classes mainly involved in classical pathway of complement activation

A

IgG1, IgG3, IgM

21
Q

which list of functions best describe sequence of events in inflammation

A

white reaction, red reaction, flare, wheal

22
Q

diabetes type 1 in which insulin producing beta cells are destroyed by immune system is classical example of

A

autoimmune disease

23
Q

difference between adaptive and innate immunity

A

innate response not amplified

i.e. reaction is same with repeated infections

24
Q

opsonisation, anaphylatoxins and membrane cell lysis are main biological functions of

A

complement system

25
what neutralises free virus in body
antibody
26
which vaccine is safest to use
inactivated
27
indirect mechanism of tissue damage in kidneys by hep. malaria and most acute infections is forming
immune complexes
28
on skin, large number bacteria - why can't pathogenic ones colonise tissue
low pH, antibacterial, microflora present
29
what are: langerhans cells, veiled cells, Kupfer cells
DC
30
where are neutrophils made
in bone marrow
31
what are neutrophils like
weaker phagocytes
32
consequences of PAMPs being recognised by TLRs immune system
phosphorylation cascade and cytokine gene activation
33
where do T and B lymphocytes develop
primary lymphoid organs independently of antigens
34
what does interferin do
warn neighbouring cells of potential virus attack
35
are exo/endo toxins primary strategies used by pathogens to damage tissue
yes
36
Rh-ve woman and Rh+ve male
baby may be at risk of haemolytic jaudice if it is couple second pregnancy
37
during development in testes what are sperm normally exposed to
IgG
38
blood vessels endothelium express selectin E and P, what are they involved in
rolling adhesion leucocytes
39
in clonal selection hypothesis where do lymphoid clones mature
generative lymphoid tissues
40
when do lymphoid clones mature
antigen absence
41
what is TCR mainly made of
alpha and beta heterodimer chains CD3 zeta chain
42
in conventional monoclonal AB therapy, reaction in problems associated with immunogenicity is seen in what order (most severe to least)
murine chimera humanised human
43
what are anti idiotype AB
monoclonal AB that bind to another AB
44
example of passive AB therapy
intravenous fusion of antitoxin
45
virus neutralising AB induced by influenza vaccines detected against
virus HA
46
why are camels/llamas AB used in many immune techniques
only posses heavy chain
47
what is the main gut AB
IgA
48
what is the main blood AB
IgG