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MCQbank SBAs Flashcards

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1
Q

Chloramphenicol rare side effect

A

Bone marrow suppression

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2
Q

carcinoid tumours vitamin deficiency

A

Niacin - pellagra

(increased tryptophan metabolism - niacin is derived from tryptophan)

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3
Q

Waldenstrom’s Macroglobulinaemia is associated with

A

Non-Hodgkin’s Lymphoma

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4
Q

P450 inhibitors i.e INCREASE drug level

A

SICKFACES.COM Group

Sodium Valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol
Ciprofloxacin
Erythromycin
Sulphonamides
Chloramphenicol
Omeprazole
Metronidazole
Grapefruit Juice

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5
Q

P450 inducers i.e. DECREASE drug level

A

CRAP GPS

Carbamazepine
Rifampicin
Alcohol
Phenytoin
Griseofulvin
Phenobarbatone
Sulphonylurea

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6
Q

DMARD causing reduced visual acuity

A

Hydroxychloroquine

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7
Q

roseola infantum is caused by

A

HHV-6
‘sixth disease’

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8
Q

Myasthenia gravis treatment (in mild disease)

A

Pyridostigmine (acetylcholinesterase inhibitor)

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9
Q

SLE antibodies

A

ANA (screening, sensitivity 95%)
Anti-dsDNA
Anti-Sm (most specific, sensitivity only 30-40%)

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10
Q

Fragile X syndrome inheritance

A

X-linked dominant

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11
Q

Paeds: Murmurs occuring during …….. are always pathological

A

Diastole

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12
Q

Sodium valproate in early pregnancy is associated with

A

neural tube defects

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13
Q

Acute otitis media is most commonly caused by

A

RSV

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14
Q

Most common childhood epilepsy

A

Benign rolandic epilepsy

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15
Q

Treatment for Onychomycosis

A

Terbinafine

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16
Q

Centor criteria for ?abx in pts presenting with sore throat

A

Tonsillar exudate
Absence of cough
Fever
Lymphadenopathy

if >=3 present -> 50% chance 2ndry to Group A strep

10 days phenoxymethylpenicillin

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17
Q

What is Uhthoff’s phenomenon

A

Worsening of symptoms in demyelinating conditions with increase in temperature e.g. hot weather, exercise

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18
Q

Cause of pneumonitis in rheumatoid patient

A

Methotrexate pneumonitis

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19
Q

most common cause of septic arthritis

A

Staph aureus

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20
Q

sarcoidosis causes a …….. ventilatory defect

A

restrictive

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21
Q

CML monoclonal antibody treatment

A

Imatinib (against philadelphia chromosome)

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22
Q

Hyperthyroid treatment in pregnancy

A

1st timester PTU
2nd and 3rd CBZ

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23
Q

HLA-B27 association

A

Ank Spond

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24
Q

lower back pain improving with exercise

A

Ank Spond

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25
diagnosis of carcinoid syndrome
urinary 5-hydroxyindoleacetic acid (5-HIAA)
26
Slapped cheek syndrome otherwise known as, caused by
Erythema infectiosum, fifth disease, parvovirus B19 infection
27
Viagra side effect - vision
Blue discolouration
28
Down and out, blown pupil
CN III lesion - extrinsic compression e.g. PICA aneurysm
29
sickle cell disease causes a .......... anaemia
normocytic
30
vitamin deficiency: cracked red lips, angular cheilitis, inflammation of mouth and tongue
Riboflavin Vit B2
31
how long can a patient be legally detained for with a section 5(2)
72hrs
32
BP treatment caucasian <55
ACEi
33
Average age diagnosis 23, SBO/intussusception, pigmented lesions buccal mucosa, GI polyps
Peutz-Jeghers syndrome Autosomal dominant
34
History of gout, worsening of symptoms following introduction of anti-hypertensive agent
Thiazide diuretic e.g. bendroflumethiazide
35
Friedrich's ataxia most likely cause of death
Cardiomyopathy
36
koplik spots are associated with
Measles
37
Antibody found commonly in Primary biliary cirrhosis
Anti-mitochondrial antibodies
38
Spleen prevents infection by ......... bacteria
encapsulated e.g. strep pneumoniae, strep pyogenes, meningococcus, group b strep
39
Max dose of simvastatin in patients on Amlodipine
20mg Amlodipine is weak cytochrome p450 inhibitor
40
Wet/exudative Age-related Macular Degeneration is characterised by
Choroidal neovascularisation
41
Absence seizure treatment
Ethosuximide Lamotrigine Valproate
42
Antistreptolysin 0 titres are raised in
Henoch-Schonlein purpura
43
Treatment for Bell's palsy
50mg Pred OD 10 days if presents within 72hrs
44
How to distinguish Labyrinthitis and vestibular neuronitis
Labyrinthitis likely to present with tinnitus/deafness This does not occur in vestibular neuronitis
45
Most common side effect of sulphonylureas e.g. Gliclazide
Hypoglycaemia
46
Normal-pressure Hydrocephalus triad
Gait Disturbance Urinary Incontinence Dementia
47
Pellagra-like dermatitis (red, scaly photosensitive rash), neurological involvement (ataxia, dysarthria, tremors, spasticity)
Hartnup disease (inborn error of metabolism)
48
What is a Pterygium
Benign wedge-shaped growth of conjunctiva extending from nasal side
49
Drug that worsens glycaemic control
Thiazide diuretics
50
How many days after conception is urine pregnancy test positive
9
51
Stage 2 hypertension, black/african-caribbean, any age
Ca2+ blocker
52
Large erythematous herald patch followed by appearance of collection of smaller patches
Pityriasis Rosea
53
Hand foot mouth causative organism
Coxsackie A16
54
Haemochromatosis triad
Diabetes Cirrhosis Skin pigmentation
55
Horner's syndrome triad
Miosis Ptosis Enopthalmos
56
Pancoast tumour pathophysiology
Apical lung tumour that can compress sympathetic chain causing Horner's syndrome
57
Commonest cause of sciatica
Herniated intervertebral disc
58
B2-MICROglobulin is associated with
Multiple myeloma
59
Increased red cell osmotic fragility
Hereditary spherocytosis
60
Drug causing increased saliva
Clozapine Neostigmine
61
Primary biliary cirrhosis antibody
Anti-MITOCHONDRIAL antibody
62
Anion gap equation
(Na+K) - (Cl+HCO3)
63
First line treatment of Generalised tonic clonic seizures
Sodium Valproate UNLESS female of reproductive age
64
Shawl/cape-like distribution of pain and temperature sensory loss over arms, trunk, shoulders
Syringomyelia (fluid filled tubular cavitation)
65
Cancer risk COCP
Increased risk BREAST & CERVICAL cancer
66
Drug causing pulmonary fibrosis and corneal deposits
Amiodarone
67
Laxative - stains urine red
Co-danthramer
68
Severely painful red eye in association with a connective tissue disorder in a middle-aged woman
Scleritis N.b. association with Rheumatoid arthritis
69
POP - one pill missed - management
Take missed pill now, condoms for 48hrs
70
Bupropion mechanism of action
Nicotinic antagonist Noradrenaline and dopamine reuptake inhibitor
71
Bupropion mechanism of action
Nicotinic antagonist Noradrenaline and dopamine reuptake inhibitor
72
Short stature, short neck, short 4th and 5th metacarpals
Pseudohypoparathyroidism - resistance to PTH Low calcium High phosphate High PTH
73
Lupus vulgaris is caused by
Cutaneous tuberculosis infection
74
Stage 1 hypertension
140/90 - 160/100 ABPM 135/85 - 150/95
75
Stage 2 hypertension
160/100 - 180/120 ABPM >150/95
76
Stage 3 hypertension
BP >180/120
77
Accelerated hypertension
>180/120 with end-organ damage
78
Effect of Tamoxifen on bone health
Reduces risk of osteoporosis - acts as oestrogen agonist in bone
79
Lambert eaton syndrome pathophysiology
Paraneoplastic. Antibodies against pre-synaptic calcium channels in NMJ Causes limb muscle weakness
80
Medication that can precipitate an acute gout flare
Allopurinol
81
Pulmonary oedema and sensorineural deafness association
LOOP DIURETICS can be ototoxic
82
Meniere's triad
Tinnitus Vertigo Hearing loss
83
Bright green fluorescence after congo-red staining
Amyloidosis
84
IBD drug causing oligospermia
Sulfasalazine
85
Congenital rubella triad
Sensorineural hearing loss Congenital heart defects - PDA, pulmonary artery stenosis Ocular defects - cataracts, retinopathy
86
Commonest cause of severe diarrhoea in HIV positive patients
Cryptosporidium
87
Marcus Gunn pupil
RAPD
88
Low levels of C1 inhibitor
Hereditary angioedema
89
Toxoplasmosis - host
Cats
90
When is mid-luteal progesterone tested
1 week before period starts
91
osler weber rendu otherwise known as
Hereditary haemorrhagic telangiectasia

MSRA (4 decks)

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