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MCQOtherBloodGroupSys Flashcards

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1
Q 
1. The following phenotypes are written incorrectly except
for:
a. Jka+
b. Jka+
c. Jka(+)
d. Jk(a+)
A
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2
Q
  1. Which of the following characteristics best describes Lewis antibodies?
    a. IgM, naturally occurring, cause HDFN
    b. IgM, naturally occurring, do not cause HDFN
    c. IgG, in vitro hemolysis, cause hemolytic transfusion
    reactions
    d. IgG, in vitro hemolysis, do not cause hemolytic transfusion reactions
A
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3
Q
  1. The Le gene codes for a specific glycosyltransferase that transfers a fucose to the N-acetylglucosamine on:
    a. Type 1 precursor chain
    b. Type 2 precursor chain
    c. Types 1 and 2 precursor chains
    d. Either type 1 or type 2 in any one individual but not
    both
A
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4
Q 
4. What substances would be found in the saliva of a group
B secretor who also has Lele genes?
a. H, Lea
b. H, B, Lea
c. H, B, Lea, Leb
d. H, B, Leb
A
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5
Q
  1. Transformation to Leb phenotype after birth may be as
    follows:
    a. Le(a–b–) to Le(a+b–) to Le(a+b+) to Le(a–b+)
    b. Le(a+b–) to Le(a–b–) to Le(a–b+) to Le(a+b+)
    c. Le(a–b+) to Le(a+b–) to Le(a+b+) to Le(a–b–)
    d. Le(a+b+) to Le(a+b–) to Le(a–b–) to Le(a–b+)
A
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6
Q
  1. In what way do the Lewis antigens change during pregnancy?
    a. Lea antigen increases only
    b. Leb antigen increases only
    c. Lea and Leb both increase
    d. Lea and Leb both decrease
A
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7
Q
  1. A type 1 chain has:
    a. The terminal galactose in a 1-3 linkage to subterminal N-acetylglucosamine
    b. The terminal galactose in a 1-4 linkage to subterminal N-acetylglucosamine
    c. The terminal galactose in a 1-3 linkage to subterminal N-acetylgalactosamine
    d. The terminal galactose in a 1-4 linkage to subterminal N-acetylgalactosamine
A
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8
Q
  1. Which of the following best describes Lewis antigens?
    a. The antigens are integral membrane glycolipids
    b. Lea and Leb are antithetical antigens
    c. The Le(a+b–) phenotype is found in secretors
    d. None of the above
A
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9
Q
  1. Which of the following genotypes would explain RBCs typed as group A Le(a+b–)?
    a. A/O Lele HH Sese
    b. A/A Lele HH sese
    c. A/O LeLe hh SeSe
    d. A/A LeLe hh sese
A
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10
Q
  1. Anti-LebH will not react or will react more weakly with which of the following RBCs?
    a. Group O Le(b+)
    b. Group A2 Le(b+)
    c. Group A1 Le(b+)
    d. None of the above
A
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11
Q
  1. Which of the following best describes MN antigens and antibodies?
    a. Well developed at birth, susceptible to enzymes, generally saline reactive
    b. Not well developed at birth, susceptible to enzymes,
    generally saline reactive
    c. Well developed at birth, not susceptible to enzymes,
    generally saline reactive
    d. Well developed at birth, susceptible to enzymes, generally antiglobulin reactive
A
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12
Q 
12. Which autoantibody specificity is found in patients with
paroxysmal cold hemoglobinuria?
a. Anti-I
b. Anti-i
c. Anti-P
d. Anti-P1
A
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13
Q
  1. Which of the following is the most common antibody
    seen in the blood bank after ABO and Rh antibodies?
    a. Anti-Fya
    b. Anti-k
    c. Anti-Jsa
    d. Anti-K
A
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14
Q 
14. Which blood group system is associated with resistance
to P. vivax malaria?
a. P
b. Kell
c. Duffy
d. Kidd
A
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15
Q 
15. The null Ko RBC can be artificially prepared by which
of the following treatments?
a. Ficin and DTT
b. Ficin and glycine-acid EDTA
c. DTT and glycine-acid EDTA
d. Glycine-acid EDTA and sialidase
A
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16
Q 
16. Which antibody does not fit with the others with respect
to optimum phase of reactivity?
a. Anti-S
b. Anti-P1
c. Anti-Fya
d. Anti-Jkb
A
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17
Q
  1. Which of the following Duffy phenotypes is prevalent
    in blacks but virtually nonexistent in whites?
    a. Fy(a+b+)
    b. Fy(a–b+)
    c. Fy(a–b–)
    d. Fy(a+b–)
A
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18
Q 
18. Antibody detection cells will not routinely detect which
antibody specificity?
a. Anti-M
b. Anti-Kpa
c. Anti-Fya
d. Anti-Lub
A
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19
Q 
19. Antibodies to antigens in which of the following blood
groups are known for showing dosage?
a. I
b. P
c. Kidd
d. Lutheran
A
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20
Q 
20. Which antibody is most commonly associated with 
delayed hemolytic transfusion reactions?
a. Anti-s
b. Anti-k
c. Anti-Lua
d. Anti-Jka
A
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21
Q
  1. Anti-U will not react with which of the following RBCs?
    a. M+N+S+s–
    b. M+N–S–s–
    c. M–N+S–s+
    d. M+N–S+s+
A
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22
Q
  1. A patient with an M. pneumoniae infection will most
    likely develop a cold autoantibody with specificity to
    which antigen?
    a. I
    b. i
    c. P
    d. P1
A
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23
Q
  1. Which antigen is destroyed by enzymes?
    a. P1
    b. Jsa
    c. Fya
    d. Jka
A
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24
Q 
1. The following phenotypes are written incorrectly 
except for:
a. Jka+
b. Jka+
c. Jka(+)
d. Jk(a+)
A
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25
2. Which of the following characteristics best describes Lewis antibodies? a. IgM, naturally occurring, cause HDFN b. IgM, naturally occurring, do not cause HDFN c. IgG, in vitro hemolysis, cause hemolytic transfusion reactions d. IgG, in vitro hemolysis, do not cause hemolytic transfusion reactions
26
3. The Le gene codes for a specific glycosyltransferase that transfers a fucose to the N-acetylglucosamine on: a. Type 1 precursor chain. b. Type 2 precursor chain. c. Types 1 and 2 precursor chain. d. Either type 1 or type 2 in any one individual but not both.
27
4. What substances would be found in the saliva of a group B secretor who also has Lele genes? a. H, Lea b. H, B, Lea c. H, B, Lea, Leb d. H, B, Leb
28
5. Transformation to Leb phenotype after birth may be as follows: a. Le(a–b–) to Le(a+b–) to Le(a+b+) to Le(a–b+) b. Le(a+b–) to Le(a–b–) to Le(a–b+) to Le(a+b+) c. Le(a–b+) to Le(a+b–) to Le(a+b+) to Le(a–b–) d. Le(a+b+) to Le(a+b–) to Le(a–b–) to Le(a–b+)
29
``` 6. In what way do the Lewis antigens change during pregnancy? a. Lea antigen increases only b. Leb antigen increases only c. Lea and Leb both increase d. Lea and Leb both decrease ```
30
7. A type 1 chain has: a. The terminal galactose in a 1-3 linkage to subterminal N-acetylglucosamine. b. The terminal galactose in a 1-4 linkage to subterminal N-acetylglucosamine. c. The terminal galactose in a 1-3 linkage to subterminal N-acetylgalactosamine. d. The terminal galactose in a 1-4 linkage to subterminal N-acetylgalactosamine.
31
8. Which of the following best describes Lewis antigens? a. The antigens are integral membrane glycolipids b. Lea and Leb are antithetical antigens c. The Le(a+b–) phenotype is found in secretors d. None of the above
32
``` 9. Which of the following genotypes would explain RBCs typed as group A Le(a+b–)? a. A/O Lele HH Sese b. A/A Lele HH sese c. A/O LeLe hh SeSe d. A/A LeLe hh sese ```
33
``` 10. Anti-LebH will not react or will react more weakly with which of the following RBCs? a. Group O Le(b+) b. Group A2 Le(b+) c. Group A1 Le(b+) d. None of the above ```
34
11. Which of the following best describes MN antigens and antibodies? a. Well developed at birth, susceptible to enzymes, generally saline reactive b. Not well developed at birth, susceptible to enzymes, generally saline reactive c. Well developed at birth, not susceptible to enzymes, generally saline reactive d. Well developed at birth, susceptible to enzymes, generally antiglobulin reactive
35
``` 12. Which autoantibody specificity is found in patients with paroxysmal cold hemoglobinuria? a. Anti-I b. Anti-i c. Anti-P d. Anti-P1 ```
36
13. Which of the following is the most common antibody seen in the blood bank after ABO and Rh antibodies? a. Anti-Fya b. Anti-k c. Anti-Jsa d. Anti-K
37
``` 14. Which blood group system is associated with resistance to P. vivax malaria? a. P b. Kell c. Duffy d. Kidd ```
38
``` 15. The null Ko RBC can be artificially prepared by which of the following treatments? a. Ficin and DTT b. Ficin and glycine-acid EDTA c. DTT and glycine-acid EDTA d. Glycine-acid EDTA and sialidase ```
39
``` 16. Which antibody does not fit with the others with respect to optimum phase of reactivity? a. Anti-S b. Anti-P1 c. Anti-Fya d. Anti-Jkb ```
40
17. Which of the following Duffy phenotypes is prevalent in blacks but virtually nonexistent in whites? a. Fy(a+b+) b. Fy(a–b+) c. Fy(a–b–) d. Fy(a+b–)
41
``` 18. Antibody detection cells will not routinely detect which antibody specificity? a. Anti-M b. Anti-Kpa c. Anti-Fya d. Anti-Lub ```
42
``` 19. Antibodies to antigens in which of the following blood groups are known for showing dosage? a. I b. P c. Kidd d. Lutheran ```
43
``` 20. Which antibody is most commonly associated with delayed hemolytic transfusion reactions? a. Anti-s b. Anti-k c. Anti-Lua d. Anti-Jka ```
44
21. Anti-U will not react with which of the following RBCs? a. M+N+S+s– b. M+N–S–s– c. M–N+S–s+ d. M+N–S+s+
45
22. A patient with an M. pneumoniae infection will most likely develop a cold autoantibody with specificity to which antigen? a. I b. i c. P d. P1
46
23. Which antigen is destroyed by enzymes? a. P1 b. Jsa c. Fya d. Jka
47
``` 24. The antibody to this high-prevalence antigen demonstrates mixed-field agglutination that appears shiny and refractile under the microscope: a. Vel b. JMH c. Jra d. Sda ```
48
``` 25. Which of the following has been associated with causing severe immediate HTRs? a. Anti-JMH b. Anti-Lub c. Anti-Vel d. Anti-Sda ```
49
``` 26. Which of the following antibodies would more likely be found in a black patient? a. Anti-Cra b. Anti-Ata c. Anti-Hy d. All of the above ```
50
``` 27. Which of the following antigens is not in a blood group system? a. Doa b. Vel c. JMH d. Kx ```
51
``` 28. A weakly reactive antibody with a titer of 128 is neutralized by plasma. Which of the following could be the specificity? a. Anti-JMH b. Anti-Ch c. Anti-Kna d. Anti-Kpa ```
52
29. An antibody reacted with untreated RBCs and DTTtreated RBCs but not with ficin-treated RBCs. Which of the following antibodies could explain this pattern of reactivity? a. Anti-JMH b. Anti-Yta c. Anti-Kpb d. Anti-Ch
53
``` 30. The following antibodies are generally considered clinically insignificant because they have not been associated with causing increased destruction of RBCs, HDFN, or HTRs. a. Anti-Doa and anti-Coa b. Anti-Ge3 and anti-Wra c. Anti-Ch and anti-Kna d. Anti-Dib and anti-Yt ```
54
The ______ for RBC surface antigens provides a standardized numeric system for naming authenticated antigens that is suitable for electronic data processing equipment. This terminology was not intended to replace conventional terminology.
ISBT terminology
55
In the ISBT classification, RBC antigens are assigned a six-digit identification number: The first three digits represent the______, and the second three digits identify the _____. All antigens are catalogued into one of the following four groups: • A blood group system if controlled by a single gene locus, or by two or more closely linked genes • A collection if shown to share a biochemical, serologic, or genetic relationship • The high-prevalence series (901) if found in more than 90% of most populations • The low-prevalence series (700) if found in less than 1% of most populations
system, collection, or series | antigen
56
_______ are not synthesized by the RBCs. These antigens are adsorbed from plasma onto the RBC membrane.
Lewis blood group antigens
57
The_____ codes for L-fucosyltransferase, which adds | L-fucose to type 1 chains.
Le gene
58
The _____ is needed for the expression of Le^a substance, and _____ are needed to form Le^b substance.
Le gene | Le and Se genes
59
The ______ is more common among blacks than among whites and results in the Le(a–b–) phenotype.
lele genotype
60
The ______ is more common among blacks than among whites and results in the Le(a–b–) phenotype.
lele genotype
61
Lewis antigens are ____ expressed at birth.
poorly
62
_____ are poorly expressed at birth.
Lewis antigens
63
Lewis antibodies are generally ____ (naturally occurring) | made by Le(a–b–) individuals.
IgM
64
_____ are frequently encountered in pregnant | women.
Lewis antibodies
65
Lewis antibodies are frequently encountered in__________
pregnant women
66
Lewis antibodies are considered/not considered significant for transfusion medicine.
not considered

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