Measuring and Describing Disease Flashcards

(45 cards)

1
Q

Define Endemic

A

Diseases that reside within a population

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2
Q

Define Epidemic

A

Diseases that befall a population

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3
Q

What is Epidemiology

A

How often diseases occur in different groups of people and why

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4
Q

What is an exposure?

A

The variable we are trying to associate with a change in health status

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5
Q

What are the three types of disease prevention?

A
  1. Primary
  2. Secondary
  3. Tertiary
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6
Q

What is primary prevention? Give an example.

A

Prevention of disease through controlling exposure to risk factors.
Example: Reducing salt intake in the diet to reduce risk of hypertension.

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7
Q

What is secondary prevention? Give an example.

A

Application of available measures to detect early departures from health and to introduce appropriate treatment and interventions.
Example: Prescribing antihypertensives for a patient with newly diagnosed hypertension.

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8
Q

What is tertiary prevention? Give an example.

A

Application of measures to reduce/eliminate long term impairments, minimising suffering caused by existing departures from good health and promoting adjustments to life with the condition.
Example: Stroke rehabilitation

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9
Q

What 6 words should guide us in epidemiological investigation?

A
  1. Who
  2. What
  3. When
  4. Where
  5. Why
  6. How
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10
Q

What are the 4 stages of epidemiologic transition?

A
  1. Pestilence and Famine
  2. Receding Pandemics
  3. Degenerative and Man-Made Diseases
  4. Delayed Degenerative Diseases and Emerging Infections
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11
Q

What characteristics are associated with the ‘Pestilence and Famine’ stage of epiodemiological transition?

A
  • Urbanisation
  • Constraints on food supply
  • High birth rate and high mortality
  • Life expectancy low at birth
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12
Q

Define Life Expectancy

A

A period of time at a specific stage. Example: Life expectancy at birth = average length of time you can expect to live for based on everyone in the population.

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13
Q

What are the characteristics of the ‘Receding Pandemics’ stage of epidemiologic transition?

A
  • Agricultural development improves nutrition
  • Life expectancy increases
  • Improvements in water, sanitation and hygiene
  • Vaccination emerges
  • High birth rate with reducing mortality = INCREASE IN POPULATION
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14
Q

What are the characteristics of the ‘Degenerative and Man-Made Diseases’ stage in epidemiologic transition?

A
  • Emergence of NCDs
  • Environmental and global determinants driving risk factors
  • Tech reduces need for physical labour
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15
Q

Describe the characteristics of the ‘Delayed Degenerative Diseases and Emerging Infections’ stage of epidemiologic transition.

A
  • Health tech defers morbidity
  • Emerging zoonoses presenting new threats
  • Inequalities between countries come to the forefront
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16
Q

What does the epidemiologic transition model demonstrate?

A

How populations, health and disease change over time

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17
Q

What was the role of epidemiology in the history of HIV? Give two points

A
  • Describing the constellations of signs and symptoms
  • Identifying the causative pathogen
  • Inferring the mechanisms of transmission
  • Determining risk factors
  • Designing prevention strategies
  • Evaluating efficacy of intervention
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18
Q

What is a case series?

A

A document comprising multiple case reports drawn together.

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19
Q

What are the two different types of study design?

A
  1. Observational research

2. Interventional research

20
Q

Whatvare the two different research methods?

A
  1. Qualitative research

2. Quantatative research

21
Q

What are the different types of epidemiological approach?

A
  1. Descriptive epidemiology

2. Analytic epidemiology

22
Q

What are DALYs?

A

Disability Adjusted Life Years - a measure of disease burden that combines years of life lost from ill-health, disability or premature death.

23
Q

What is the definition of ‘odds’?

A

The ratio of the probability (P) of an event to the probability of its complement (1-P)

24
Q

What are the four measures of frequency?

A
  1. Odds
  2. Prevalence
  3. Cumulative Incidence
  4. Incidence Rate
25
How do we calculate odds?
Odds= Number of people with the disease / Number of people who don’t
26
What is Prevalence?
The proportion of individuals in a population who have the disease or attribute of interest at a specific timepoint
27
How do we calculate Prevalence?
Number of people with the disease / Total number of individuals in the population
28
What is a weakness of using prevalence?
- Provides no information of new cases of a disease | - Not useful if a disease has a short duration
29
Define Cumulative Incidence
The proportion of the population with a new event during a given time period
30
How do we calculate Cumulative Incidence?
Number of NEW cases during the period of interest / Number of disease-free individuals at the START of this time period
31
What does a cumulative incidence of 1 (100%) mean?
All individuals developed the disease during the given time period
32
What is a weakness of Cumulative Incidence?
- Only calculated if there is a follow up of the participants in the study - Follow up period must be the same for all participants
33
How is Incidence Rate calculated?
The number of new cases during the follow-up period / total person-time by disease-free individuals
34
What is cumulative incidence also known as?
Risk
35
What does Person-Time measure
The time participants spend in the study
36
Define Incidence Rate
Number of NEW cases per unit of person-time
37
What is a strength of using Incidence Rate?
- Accounts for the time of follow-up - Accounts for the time when the new event occurred - Suitable for studies where participants enter or leave at different times - Can deal with loss to follow-up
38
When is indirect standardisation used?
Where direct standardisation is not possible
39
What is the use of standardisation?
Enables comparison of incidence and prevalence data by adjusting outputs by one or more other variables
40
What is the use of Direct Standardisation
Gives comparable incidence e.g. 120 strokes per 100k/year
41
Distribution where the proportion of older ages towards the top of the distribution are greater than those below
Coffin shaped distribution
42
What is the distribution shape where there are fewer older people and more people in the working age population?
Pyramid shape
43
What is Direct Standardisation?
Type of adjustment that allows us to compare like-for-like between populations
44
How can the Standardised Mortality Ratio (SMR) be calculated?
Divide the observed count by the expected count
45
What are the limitations of a crude rate?
Not adjusted for age or sex variation in the population measured