Mechanism of Action Flashcards

1
Q

Mesalamine (Pentasa, Asacol HD)

A

exact MOA is unknown, may have anti-inflammatory effect in GI

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2
Q

Infliximab (Remicade)

A

Anti-TNF agent that prevents induction of proinflammatory cytokines

**indicated for both CD and UC

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3
Q

Methotrexate (Trexall)

A

Antimetabolite that has anti-folate mechanisms and anti-inflammatory effects

**Indicated for CD only

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4
Q

Azathioprine

A

Immunosuppressive antimetabolite that blocks purine synthesis and also has anti-inflammatory effects

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5
Q

Cyclosporine

A

Calcineurin Inhibitor that has immunosuppressive properties ONLY indicated for severe UC

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6
Q

Ustekinumab (Stelara)

A

IL receptor antagonist

**indicated for anti-TNF intolerate mod-severe UC or CD patients

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7
Q

Golimumab (Simponi)

A

Anti-TNF agent that blocks cytokines

**only indicated for UC

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8
Q

Certolizumab (Cimzia)

A

Anti-TNF agent that blocks cytokines

**only indicated for CD

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