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QUESTIONS ECEIM 1 > Mechanism Of Action Drugs > Flashcards

Mechanism Of Action Drugs Flashcards

(80 cards)

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1
Q

TMPS

A

Inhibition DNA synthesis by interfering on folate pathway

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2
Q

Fluoroquinolones

A

Inhibition DNA synthesis by interfering on DNA gyrase

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3
Q

Macrolides

A

Inhibitiln of dna synthesis by interfering on RNA polymerasa

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4
Q

Metromidazol

A

Creates free radicals inside bacteria

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5
Q

BLactams

A

Interfere on cell wall synthesis: Act on ezymes called penicillin binding proteins (PBPs) and it produces a lysisnof the cell

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6
Q

Tetracyclines

A

Inhibition of protein synthesis: act on 30s ribosome

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7
Q

Aminoglycosides

A

Inhibition of protein synthesis: act on 30s ribosome

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8
Q

Macrolides

A

Inhibition of protein synthesis: act on 50s ribosome

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9
Q

Cloramohenicol

A

Inhibition of protein synthesis: act on 50s ribosome

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10
Q

Pergolide

A

Dopamine D2 agonist

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11
Q

Bromocriptine

A

Dopamine D2 agonist

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12
Q

Cabergoline

A

Dopamine D2 agonist

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13
Q

Ciproheptadine

A

Serotonine antagonist, treatement of PPId

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14
Q

Metformine

A

AMPK agonist, helping entering glucose into the cells
Reduces glucose and insuline levels
Low bioavailability

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15
Q

Levothyroxine

A

Synthetic T4: same action than thyroid hormones: increases gluconeogenesis, protein synthesis, mobilization glycogen stores = increases metabolic rate in the cells

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16
Q

Pentoxifiline

A

Phosphodiesterasa (pde) inhibitor

cAMP —(pde)——>5AMP —-> secretion cytokines

AE: decreases blood viscosity

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17
Q

DMSO

A

Scavenge derived radicals

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18
Q

Polymyxin B

A

Binds lipid A portion of LPS and neutralizes endotoxin capacity

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19
Q

Lidocaine

A

Block Na channels

AE: muscle fasciculations, ataxia, seizure

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20
Q

Bethanecol

A

Parasympathicomymetic acting smooth muscle throw muscarinic receptors
Muscarinic cholinergic agonist- stimulates ACh receptors

AE: cholinergic effects: abdominal pain, sweating, salivation

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21
Q

Mitomycin C

A

Decreases collagen cross linking and inhibits fibroblast proliferation

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22
Q

Neostigmine

A

Inhibition cholinesterasa, increasing levels of Ach binding to muscarining receptors

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23
Q

Metroclopramide

A

5HT-4 agonist
5HT-3 antagonist
Dopamine antagonist

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24
Q

Cisapride

A

5HT-4 agonist

5HT-3 antagonist

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25
Domperidone
Antagonist D2 receptors
26
Erythromycin
Motilin receptor agonist
27
Acepromazine
Dopamine receptor antagonist
28
Furosemide
Na/K/Cl pump inhibitor in the ascending loop henle AE: hypokalemia, hyponatremia, hypocloremia ans hypomagnesemia. It increases digoxin toxicity effects
29
ACE inhibitors (benazepril)
Inhibits RAAS system | ACE inhibitors avoid conversion of AT1 to AT2
30
Digoxin
Inhibits na/kATPase pump: causing na to accumulate into the cell preventing calcium to go out too fast from the cell. Allowing more calcium available to be released from the sarcoplasmatic reticulum, enhancing contraction AE: colic, diarrhea, anorexia, arritmias
31
Aspirin
Irreversible inhibits COX in platelets, inhibiting gormation thromboxane
32
Acetaminophen
Mild effect on COX. Acts on Serotonergic and cabbinoid pathways
33
Ketamine
NMDA antagonist
34
Tramadol
Seritonine antagonist and u agonist
35
Azathioprine
Is an imidazole antimetabolite that acts as a purine antagonist, competing with the synthesis of nucleic acids
36
Morphine
U receptor agonist
37
Methadone
U receptor agonist and NMDA antagonist
38
Butorphanol
K agonist and u antagonist
39
Corticosteroids
Inhibitor of phospholipase A2, inhibiting formation of arachidonic acid
40
Buscopan
Muscarinic antagonist
41
Methacarbamol
Works on the postsynaptic activity. It decreases nerve transmission and prolongs refrsctory period of muscle cells
42
Doxapram
Stimulates the receptors in the carotid seno, who consequently stimulate the respiratory center
43
Timolol
B blocker (decreases aqueus humor)
44
Dorzolamide
Inhibitor of carbonic anhydrase
45
Aciclovir/valaciclovir
Synthetic purine nucleoside analog that selective inhibits replication EHV
46
Acetylcysteine
Rupting disulfide bonds in mucoprotein molecules, reducing mucus viscosity
47
MgSO4
Ca channel blocker and activator if the na/k atpase
48
Deferoxamine
Inhibits cell iron uptake
49
Heparin
Binds reversibly to antithrombin 3 and accelerates the inactivation of coagulation at the level of the factor 2 and 10
50
Aminocaproic and tranaxemic acid
Inactivates plasmin (antifibrinolytic)
51
Clopidogrel (antiplatelet medication)
Inhibits ADP receptors
52
Psyllium
Increases production of SCFAs in the colon
53
Misoprostol
Protaglandin analogue and prodtanoid antagonist
54
Benzodiazepine
Binds GABA receptors
55
Phenobarbital
- facilitates the effect of GABA - potentiates glutamate - blocks ca channel
56
Phenitoine
Blocks Na channels, prevents glutamate release
57
Salbutamol, albuterol, clenbuterol
B2 agonist
58
Ipatropium
Anticholinergic bronchodilator
59
Sodium chromoglycate (for asthma)
Mast cell stabilizer it blocks ca channel inhibiting release of histamine
60
Gallium (for rhodo treatement)
Inactivation of iron blocking dna synthesis
61
Dantrolene
Decreases frequency of ca channel opening, Blockyng RYR R
62
Fluohenazine
Blocks dopamine receptors
63
Hydralazine
Smooth muscle relaxant - vasodilator primarly of arterioles -inhibition of inositol triphosphate induces calcium release in the Sarcoplasmatic reticulum in arterial smooth muscle cells
64
Amiloride (for congestice heart failure)
Potassium-sparing diuretic | Na channel blocker in the convoluted distal tubule and collecting duct
65
Spironolactone
Block type 1 mineralocorticoid/glucocorticoid receptors (aldosterone antagonist)
66
Thiazide diuretic
Blocks na/cl in the distal convulted tubule
67
Type I antiarrythmic
Block fast sodium channel 1a quinidine and procainamide 1b lidocaine and phenitoime 1c propafenone and flecainide
68
Class 2 antiarrythmic
B1 blocker Propanolol and solatolol
69
Class 3 antiarrythmics
k channel blocker Amiodorone and bretylium
70
Noradrenaline
X1 and B1
71
Phenilephrine
X1
72
Dopamine
X1, b1, b2 et d receptors
73
Dobutamine
B1
74
Yohimbine
Alpha2 antagonist
75
Tpa
Converts inactive plasminogen to plasmin
76
Naloxone
U opioid receptor antagonist
77
Alvimopan
U opioid receptor antagonist | Prokinetics effects
78
Tegaserod
5HT4 agonist
79
Metformine
Ampk agonist
80
Digoxin
Cardiac glycoside It works keeping calcium in the cell and increasing contraction, Inhibits Na/K atpase and then na stays in the cell and so calcium doesnt go out w the calcium/na pump. It also decreases HR affecting the vagus nerve

QUESTIONS ECEIM 1 (3 decks)

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