Mechanisms/Drug Class

Question 1

What is the mechanism of action of NSAIDs?

Answer 1

Inhibit cyclooxygenase, COX-1 and COX-2, decreasing the biosynthesis of downstream eicosanoids and thereby limiting the inflammatory response

Question 2

aspirin

Answer 2

NSAID

Question 3

ibuprofen

Answer 3

NSAID (propionic acid)

Question 4

naproxen

Answer 4

NSAID (propionic acid)

Question 5

ketoprofen

Answer 5

NSAID (propionic acid)

Question 6

flurbiprofen

Answer 6

NSAID (propionic acid)

Question 7

indomethacin

Answer 7

NSAID (acetic acid)

Question 8

sulindac

Answer 8

NSAID (acetic acid)

Question 9

etodolac

Answer 9

NSAID (acetic acid)

Question 10

etodolac

Answer 10

NSAID (acetic acid)

Question 11

diclofenac

Answer 11

NSAID (acetic acid)

Question 12

keterolac

Answer 12

NSAID (acetic acid)

Question 13

piroxicam

Answer 13

NSAID (oxicam)

Question 14

mefenamate

Answer 14

NSAID (fenamates)

Question 15

meclofenamate

Answer 15

NSAID (fenamates)

Question 16

nabumetone

Answer 16

NSAID (ketone)

Question 17

What is the mechanism of action of acetaminophen?

Answer 17

Weak inhibitor of peripheral cyclooxygenases; predominant effect may be inhibition of COX-3 in the CNS

Question 18

What is the mechanism of action of COX-2 selective inhibitors?

Answer 18

Selective inhibition of COX-2

Question 19

celecoxib

Answer 19

COX-2 selective inhibitor

Question 20

What is the mechanism of action of glucocorticoids?

Answer 20

Inhibit COX-2 action and prostaglandin biosynthesis by inducing lipocortins, activating endogenous anti-inflammatory pathways and other mechanisms (phospholipase A2 inhibition)

Question 21

prednisone

Answer 21

glucocorticoid

Question 22

prednisolone

Answer 22

glucocorticoid

Question 23

methylprednisolone

Answer 23

glucocorticoid

Question 24

dexamethasone

Answer 24

glucocorticoid

Question 25

What is the mechanism of action of cytokine antagonists?

Answer 25

Inhibition of TNF-alpha (by etanercept, infliximab, adalimumab, golimumab, and certolizumab); inhibit IL-1 (by anakinra)

Question 26

etanercept

Answer 26

cytokine antagonist

Question 27

infliximab

Answer 27

cytokine antagonist

Question 28

adalimumab

Answer 28

cytokine antagonist

Question 29

golimumab

Answer 29

cytokine antagonist

Question 30

certolizumab

Answer 30

cytokine antagonist

Question 31

What is the mechanism of action of prostanoid mimetics?

Answer 31

Prostanoid receptor agonists

Question 32

alprostadil

Answer 32

prostanoid mimetic

Question 33

misoprostol

Answer 33

prostanoid mimetic

Question 34

carboprost

Answer 34

prostanoid mimetic

Question 35

latanoprost

Answer 35

prostanoid mimetic

Question 36

bimatoprost

Answer 36

prostanoid mimetic

Question 37

travoprost

Answer 37

prostanoid mimetic

Question 38

epoprostenol

Answer 38

prostanoid mimetic

Question 39

What is the mechanism of action of thromboxane antagonists?

Answer 39

Inhibit thromboxane synthase or antagonize thromboxane receptor (investigational agents)

Question 40

dazoxiben

Answer 40

thromboxane antagonist

Question 41

pirmagrel

Answer 41

thromboxane antagonist

Question 42

ridogrel

Answer 42

thromboxane antagonist

Question 43

What is the mechanism of action of lipoxygenase inhibitors?

Answer 43

Inhibits 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid

Question 44

zileuton

Answer 44

lipooxygenase inhibitor

Question 45

What is the mechanism of action of leukotriene receptor antagonists?

Answer 45

Selective antagonists of the cysteinly leukotriene (CysLT) type-1 receptor

Question 46

anakinra

Answer 46

cytokine antagonist