Mechanisms/Drug Class Flashcards
what is the MoA of glucocorticoid receptor agonists
mimic cortisol function by acting as agonists at the glucocorticoid receptor
prednisone
glucocorticoid rec agonist
prednisolone
glucocorticoid rec agonist
methylprednisolone
glucocorticoid rec agonist
dexamethasone
glucocorticoid rec agonist
hydrocortisone
glucocorticoid rec agonist
fluticasone
glucocorticoid rec agonist
beclomethasone
glucocorticoid rec agonist
flunisolide
glucocorticoid rec agonist
triamcinolone
glucocorticoid rec agonist
budesonide
glucocorticoid rec agonist
what is the MoA of glucocorticoid rec antagonists
competitive antagonist of cortisol action at the glucocorticoid receptor
mifepristone (RU-486)
glucocorticoid receptor antagonist
what in the MoA of inhibitor of glucocorticoid synthesis
inhibit various steps in glucocorticoid hormone biosynthesis
mitotane
inhibitor of glucocorticoid synthesis
aminoglutethimide
inhibitor of glucocorticoid synthesis
metyrapone
inhibitor of glucocorticoid synthesis
trilostane
inhibitor of glucocorticoid synthesis
ketoconazole
inhibitor of glucocorticoid synthesis
what is the MoA of meneralocorticoid rec agonists?
agonist at mineralocorticoid receptor
fludrocortisone
mineralocorticoid rec agonist
what is the MoA of mineralocorticoid rec antagonist
competitive antagonist of aldosterone action at the mineralocorticoid rec
spironolactone
collecting duct/K+ sparing diuretic and mineralocorticoid rec antagonist
eplerenone
collecting duct/K+ sparing diuretic and mineralocorticoid rec antagonist