Mechanisms of pathogencity Flashcards Preview

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Flashcards in Mechanisms of pathogencity Deck (13):
1

Pathogens

Microbes capable of causing host damage
When certain threshold reached = disease

2

Pathogencity

Ability to cause diasease by overcoming defences of the host

3

Virulence

Degree or extent of pathogencity

4

Virulence factors

Something which enhances the pathogencity
adhesions, organelles, damage to host, toxins

5

Mechanisms of pathogencity

Portal of entry --> Adherance --> penetration of host --> damage to host

6

Portal of entry

Surgical procedures, cuts

Stapylococcus aerus and epidermis are normal flora of the skin and enter this way

Preferred portals

7

Adherance

ATTACHMENT
Means of adhesins or ligands
Gram + use other structures for adhesions

8

Invasion

Production of surface proteins called invasins or production of enzymes

9

Damage to host cell

Direct damage
Endo and exotoxins

10

Endotoxins

Part of outer celll and liberated when bacteria dies
Host then binds to pathogen

11

Exotoxin

Initially outsude cell then transported into host cell
Then released to surrounding medium

12

Endo toxin examples

DNase
Clostridium perfringens
a toxin

13

Exotoxin examples

Diptheria
tetnus
Botulinum
Vibro
Erythogenic
Staphylococcus