Medication Formulary Flashcards

1
Q

Amiodarone Class

A

Antiarrhythmic Agent

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2
Q

Amiodarone Description

A

Class III Antiarrhythmic agent used to treat ventricular arrhythmias

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3
Q

Amiodarone Presentation

A

150mg in 3ml solutionPre-filled Syringes 10ml (30 mg/ml)

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4
Q

Amiodarone Administration

A

Inreavenously (IV)Intraosseous (IO)

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5
Q

Amiodarone Indications

A

Ventricular Fibrillation andPulseless Ventricular Tachycardia

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6
Q

Amiodarone Contraindications

A

KSARKnown Hypersensitivity To Iodine

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7
Q

Amiodarone Dosages

A

Adult: 5mg/Kg IV/IO (Loading dose in Cardiac Arrest 300mg and supplemental dose of 50mgPaed: 5mg/Kg

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8
Q

Amiodarone Pharmacology

A

AntiarrhythmicProlongs the action potentialProlongs the refractory periodProlongs atrioventricular conductionProlongs QT Interval

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9
Q

Amiodarone Side Effects

A

Inflammation of peripheral veinsBradycardiaAV conducting abnormalities

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10
Q

Amiodarone Additional Info

A

If diluted mix with Dextrose 5%May be flushed with NaCl

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11
Q

Aspirin Class

A

Platelet Aggregator Inhibitor

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12
Q

Aspirin Description

A

Anti-inflammatory agent and an inhibitor of platelet function.Useful agent in the treatment of various thromboembolic diseases such as acute myocardial infarction

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13
Q

Aspirin Presentation

A

3000mg soluble tablet

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14
Q

Aspirin Administration

A

Orally (PO) - if soluble, disperse in water. if non soluble, to be chewed.

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15
Q

Aspirin Indications

A

Cardiac chest pain or suspected myocardial infarction

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16
Q

Aspirin Contraindications

A

Active symptomatic gastro-intestinal ulcerBleeding disorder (e.g. Haemophilia)KSARPatients < 16 yrs old

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17
Q

Aspirin Dosages

A

Adult: 300mgPaed: not indicated

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18
Q

Aspirin Pharmacology

A

AntithromboticInhibits the formation of thromboxane A2, which stimulates platelet aggregation and artery constriction.This reduces clot/thrombus formation in an MI

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19
Q

Aspirin Side Effects

A

Epigastric pain and discomfortBronchospasmGastrointestinal Haemorrhage

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20
Q

Aspirin Additional Info

A

Aspirin 300mg is indicated for cardiac chest pain regardlessif patient is on anti-coagulants or is already on aspirin.If the patient has swallowed an aspirin (enteric coated) preparation without chewing it, the patient should be regarded as not having taken any aspirin; Administer Aspirin 300mg PO.

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21
Q

Atropine Class

A

Anticholinergic

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22
Q

Atropine Description

A

Parasympatholytic that is derived from the Atropa Belladonna plant

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23
Q

Atropine Presentation

A

Pre-filled syringe 1mg/10mlAmpoule 0.6mg in 1ml

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24
Q

Atropine Administration

A

Intravenous (IV)Intraosseous (IO)

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25
Atropine Indications
Symptomatic BradycardiaOrganophosphate Poisoning
26
Atropine Contraindications
KSAR
27
Atropine Dosage
Organophosphate Poisoning - 1mg IV, Repeat at 3-5min intervals to ensure minimal salivary secretions.Symptomatic Bradycardia - 0.5mg IV. Repeat at 3-5min intervals to max 3mg.
28
Atropine Pharmacology
Anticholinergic agentBlocks acetylcholine receptors-enhances SA node automaticity-enhances AV node conduction-increases heart rate
29
Atropine Side Effects
TachycardiaDry MouthDilated Pupils
30
Atropine Additional Info
Accidental exposure to the eye causes blurred vision
31
Benzylpenicillin Class
Antibiotic, antibacterial
32
Benzylpenicillin Descriptions
Benzylpenicillin is an antibiotic agent
33
Benzylpenicillin Presentation
Intravenous (IV) or Intraosseous (IO).May give by IM injection if no IV access.IV/IO - Reconstitute each 600mg vial with 4ml of water for injection and give by slow IV injection over 3-5mins.IM - Reconstitute each 600mg vial with 2ml of water for injection
34
Benzylpenicillin Administration
Intravenous (IV)Intrados serous (IO)
35
Benzylpenicillin Indications
Suspected or confirmed Meningococcal Sepsis
36
Benzylpenicillin Contraindications
KSAR
37
Benzylpenicillin Dosage
Adult - 1200mg IV, IO or IMPaed - > 8 yrs - 1200mg1-8 yrs - 600mg< 1 yr - 300mg
38
Benzylpenicillin Pharmacology
AntibacterialGram positive cocci antibiotic
39
Benzylpenicillin Side Effects
Gastro-intestinal disturbancesHypersensitivity rections
40
Benzylpenicillin Additional Info
Also called Penicillin G
41
Clopidogrel Class
Platelet aggregator inhibitor
42
Clopidogrel Description
An inhibitor of platelet function
43
Clopidogrel Administration
Orally (PO)
44
Clopidogrel Indications
Identification of ST Elevation Myocardial Infarction (STEMI)
45
Clopidogrel Contraindications
KSARActive Pathological BleedingSevere Liver Impairment
46
Clopidogrel Doseage
600mg PO> 75yrs 75mg PO
47
Clopidogrel Pharmacology
Clopidogrel selectivelyinhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, and the subsequent ADP - mediated activation of the GPIIb/IIIa complex, thereby inhibiting platelet aggregation.Biotransformation of clopidogrel is necessary to produce inhibition of platelet aggregation. Clopidogrel acts by irreversibly modifying the platelet ADP receptor
48
Clopidogrel Side Effects
Abdominal PainDyspepsiaDiarrhoea
49
Clopidogrel Additional Info
Paramedics are authorised to administer Clopidogrel PO following identification of STEMI and medical practitioner instruction
50
Cyclizine Class
Anti-emetic
51
Cyclizine Descriptions
Used in management of nausea and vomiting
52
CyclizinePresentation
Ampoule 50mg in 1ml
53
Cyclizine Administration
Intravenous (IV)Intraosseous (IO)
54
Cyclizine Indications
Management, prevention and treatment of nausea and vomiting
55
Cyclizine Contraindications
KSAR
56
Cyclizine Dosage
Adult - 50mg IV/IOPaed - not indicated
57
Cyclizine Pharmacology
Anti-emetic
58
Cyclizine Side Effects
TachycardiaDry MouthSedation
59
Cyclizine Additional Info
IM route should only be utilised where IV or IO access is not available
60
Dextrose 10% Solution Class
Carbohydrate
61
Dextrose 10% Solution Description
Dextrose is used to describe the six-carbon sugar d-glucose, which is the principal form of carbohydrate used by the body.D10W is a hypertonic solution
62
Dextrose 10% Solution Presentation
Soft pack for infusion 250ml and 500ml
63
Dextrose 10% Solution Administration
Intravenous (IV)Intraosseous (IO)
64
Dextrose 10% SolutionIndications
Hypoglycaemic emergencyBlood glucose level < 4 mmol/L
65
Dextrose 10% Solution Contraindications
KSAR
66
Dextrose 10% Solution Doseage
Adult - 250ml IV/IORepeat X 1 prnPaed - 5ml/KgRepeat X 1 prn
67
Dextrose 10% Solution Pharmacology
Hypertonic glucose solutionReadily utilisable energy sourse
68
Dextrose 10% Solution Side Effects
Necrosis of tissue around IV access
69
Dextrose 10% Solution Additional Info
Also called GlucoseCannula patency will reduce the effect of tissue necrosis
70
Epinephrine 1:10,000Class
Sympathetic Agonist
71
Epinephrine 1:10,000Description
Naturally occurring catecholamine. It is a potent alpha and beta adrenergic stimulant; however, its effect on beta-receptors is more profound
72
Epinephrine 1:10,000Presentation
Pre-filled syringe 1mg/10ml (1:10,000) as 0.1mg/ml
73
Epinephrine 1:10,000Administration
Intravenous (IV)Intraosseous (IO)
74
Epinephrine 1:10,000Indications
Cardiac ArrestPaediatric Symptomatic Bradycardia unresponsive to other measures
75
Epinephrine 1:10,000Contraindications
KASR
76
Epinephrine 1:10,000Dosage
Adult: Cardiac Arrest 1mg (1:10,000)Repeat every 3-5 minsPaed:Cardiac Arrest 0.01mg/kg (0.1ml/mg) (1:10,000)Repeat every 3-5 minsBradycardia 0.01mg/kg (0.1ml/mg) (1:10,000)Repeat every 3-5 mins
77
Epinephrine 1:10,000Pharmacology
Alpha and beta adrenergic stimulantIncreases heart rate - Chronotropic effectIncreases Myocardial contractions - inotropic effectIncreases Blood PressureIncreases electrical activity in the myocardiumincreases cerebral and coronary blood flowDilation of the bronchioles
78
Epinephrine 1:10,000Side Effects
In non cardiac arrest patients-Palpatationa-Tachyarrhythmias-Hypertension
79
Epinephrine 1:10,000Additional Info
N.B. Double check concentrations before use
80
Epinephrine 1:1,000Class
Sympathetic Agonist
81
Epinephrine 1:1,000Description
Naturally occurring catecholamine. It is a potent alpha and beta adrenergic stimulant; however, its effect on beta-receptors is more profound
82
Epinephrine 1:1,000Presentation
Pre-filled syringe, ampoule or auto injector1mg/ml (1:1,000)
83
Epinephrine 1:1,000Administration
Intramuscular (IM)
84
Epinephrine 1:1,000Indications
Severe Anaphylaxis
85
Epinephrine 1:1,000Contraindications
None known
86
Epinephrine 1:1,000Dosages
Adult:0.5mg (500mcg) (1:1,000) IMRepeat every 3-5 mins if indicatedPaed:8yrs - 0.5mg (500mcg) (.05ml)repeat every 3-5 mins if indicated
87
Epinephrine 1:1,000Pharmacology
Alpha and beta adrenergic stimulant.Reversal of laryngeal oedema and bronchospasm in anaphylaxis.Antagonises effects of histamine
88
Epinephrine 1:1,000Side Effects
PalpitationsAngina like symptomsTachyarrhythmiasHypertension
89
Epinephrine 1:1,000Additional Info
N.B. Double check the concentration on pack before use
90
FurosemideClass
Diuretic
91
FurosemideDescription
A loop diuretic
92
FurosemidePresentation
10mg per mL2ml, 5ml, 25ml Ampoule
93
FurosemideAdministration
Intravenous (IV)
94
FurosemideIndication
Pulmonary Oedema
95
FurosemideContraindications
PregnancyHypokalaemiaKSAR
96
FurosemideDosage
Adult: 40mg IVPaed: not indicated
97
FurosemidePharmacology
Acts on the ascending loop of Henle by inhibiting the reabsorption of Chloride and Sodium ions into the interstitial fluid. This results in a relative hypertonic state. Water is retained in the loop and eliminated via the bladder.It also causes venodilation which reduces venous return to the heart
98
FurosemideSide Effects
HeadacheDizzinessHypotensionArrhythmiasTransient deafnessDiarrhoeaNausea Vomiting
99
Furosemide Additional Info
Furosemide should be protected from light
100
GlucagonClass
Hormone and Anti-hypoglycaemic
101
GlucagonDescription
Glucagon is a protein secreted by the alpha cells of the Islets of Langerhans in the pancreas. It is used to increase the blood glucose level in cases of hypoglycaemia in which an IV cannot by immediately be placed
102
GlucagonPresentation
1mg vial powder for reconstitution (1ml)
103
GlucagonAdministration
Intramuscular (IM)
104
GlucagonIndications
Hypoglycaemia in patients unable to take oral glucose or unable to gain IV access with a blood glucose level <4mmol/L
105
GlucagonContraindications
KSARPhaeochromocytoma
106
GlucagonDosage
Adult: 1mg IMPaed: ≤ 8yrs 0.5mg IM> 8yrs 1mg IM
107
GlucagonPharmacology
Glycogenolysis.Increases plasma glucose by mobilising glycogen stored in the liver
108
GlucagonSide Effects
Rare: may cause Hypotension, dizziness, headache, nausea & Vomiting
109
GlucagonAdditional Info
May be ineffective in patients with low stored glycogen e.g. prior use in previous 24 hours, alcoholic patients with liver disease.Protect from light
110
Glucose GelClass
Anti-hypoglycaemic
111
Glucose GelDescription
Synthetic glucose paste
112
Glucose GelPresentation
Glucose gel in a tube or sachet
113
Glucose GelAdministration
Buccal Administration (BU)Administer gel to the inside of the patient's cheek and gently massage the outside of the cheek
114
Glucose GelIndications
HypoglycaemiaBlood glucose <4 mmol/L
115
Glucose GelContraindications
KSAR
116
Glucose GelDosages
Adult: 10 - 20g buccalPaed: ≤ 8yrs: 5 - 10g buccal> 8yrs: 10 - 20g buccal
117
Glucose GelPharmacology
Increases blood glucose levels
118
Glucose GelSide Effects
May cause vomiting in patients under the age of five if administered too quickly
119
Glucose GelAdditional Info
Glucose gel will maintain glucose levels once raised but should be used secondary to Dextrose or Glucagon to reverse hypoglycaemia.Proceed with caution:- patients with airway compromise-altered level of consciousness
120
EnoxaparinClass
Anticoagulant
121
EnoxaparinDescription
Enoxaparin is a Low Molecular Weight Heparin used in conjunction with a thrombolytic agent for the treatment of STEMI
122
EnoxaparinPresentation
Prefilled syringes (100mg/mL)
123
EnoxaparinAdministration
Intravenous (IV)
124
EnoxaparinIndications
Acute STEMI immediately following the administration of a thrombolytic agent
125
EnoxaparinContraindications
Active major bleeding disorders and conditions with a high risk of uncontrolled haemorrhage, including recent haemorrhagic stroke or subdural haematoma; in jaundice; active gastric or duodenal ulceration; hiatal ulceration; threatened abortion, or retinopathy.Hypersensitivity to Enoxaparin or other LMWH.KSAR
126
EnoxaparinDosage
Adult: 30mg IV BolusPaed: not indicated
127
EnoxaparinPharmacology
It binds to the natural inhibitor of coagulation, anti-thrombin III and makes certain clotting factors inactive. This results in an increase in the clotting time
128
EnoxaparinSide Effects
Pain, Haematoma and mild local irritation may follow the subcutaneous injection
129
EnoxaparinAdditional Info
Do not store above 25°CDo not refrigerate or freeze.
130
GTNClass
Nitrate
131
GTNDescription
Special preparation of Glyceryl Trinitrate in an aerosol form that delivers precisely 0.4mg of GTN per spray
132
GTNPresentation
Aerosol spray: metered dose 0.4mg (400mcg)
133
GTNAdministration
Sublingual (SL)
134
GTNIndications
AnginaSuspected Myocardial Infarction (MI)Pulmonary Oedema
135
GTNContraindications
Sys BP <90 mmHgViagra or other Phosphodiesterase type 5 inhibitors (sildenafil,taladafil, vardenafil) used within previous 24 hoursKSAR
136
GTNDosage
Adult:Angina or MI: 0.4mg repeat at 3-5 mins to max 1.2mgPulmonary Oedema: 0.8mg Repeat X 1Paed: not indicated
137
GTNPharmacology
VasodilatorReleases nitric oxide which acts as a vasodilator. Dilates coronary arteries particularly if in spasm, increasing blood flow to the myocardium.Dilates systemic veins reducing venous return to the heart (preload) and thus reduces the heart workload.Reduces BP.
138
GTNSide Effects
HeadacheTransient HypotensionFlushingDizziness
139
GTNAdditional Info
If the pump is new or has not been used for a week or more the first spray should be released into the air
140
HydrocortisoneClass
Corticosteroid and anti-inflammatory
141
HydrocortisoneDescription
Hydrocortisone is a potent corticosteroid with anti-inflammatory properties
142
HydrocortisonePresentation
Powder and solvent for solution for injection or infusion.Vial containing off white powder and vial containing water for injections. Prepare the solution aseptically by adding not more than 2ml of sterile water for injections to the contents of one 100mg vial, shake and withdraw for use.
143
HydrocortisoneAdministration
Intravenous (IV)Intramuscular (IM)The preferred route for initial emergency use is intravenous
144
HydrocortisoneIndications
Severe or recurrent anaphylactic reactionsPatients with asthma following an anaphylactic reactionExacerbation of COPD
145
HydrocortisoneContraindications
No major contraindications in acute management of anaphylaxis
146
HydrocortisoneDosage
Adult: 200mg IM or slow IV (over 1 - 10mins)Paed:< 1 year - 25mg IM or slow IV (over 1 - 10mins)1 to 5 years - 50mg IM or slow IV (over 1 - 10mins)6 to 12 years - 100mg IM or slow IV (over 1 - 10mins)> 12 years - 130mg IM or slow IV (over 1 - 10mins)
147
HydrocortisonePharmacology
Potent anti-inflammatory properties and inhibit many substances that cause inflammation. the half life is 90 mins
148
HydrocortisoneSide Effects
CCF, Hypertension, Abdominal distension, Vertigo, Headache, Nausea, Malaise and Hiccups
149
HydrocortisoneAdditional Info
Intramuscular injection should avoid the deltoid area because of the possibility of tissue atrophy.Dosage should not be less than 25mg
150
IbuprofenClass
Non-steroidal anti-inflammatory drugs (NSAIDs)
151
IbuprofenDescription
It is used to reduce mild to moderate pain
152
IbuprofenPresentation
Suspension 100mg in 5ml200mg tablet
153
IbuprofenAdministration
Orally (PO)
154
IbuprofenIndications
Mild to moderate pain
155
IbuprofenContraindications
Not suitable for children under 3 monthsPatient with history of asthma exacerbated by aspirinPregnancyPeptic ulcer diseaseKSAR
156
IbuprofenDosages
Adult: 400mg (PO)Paed: 10mg/Kg (PO)
157
IbuprofenPharmacology
Suppresses prostaglandins, which cause pain via its inhibition of cyclooxygenase (COX).Prostaglandins are released by cell damage and inflammation
158
IbuprofenSide Effects
Skin Rashes, GI Intolerance and bleeding.LTSE - Occasionally Gi Bleeding and ulceration occurs.May also cause acute renal failure, interstitial nephritis and nephritic syndrome
159
IbuprofenAdditional Info
If ibuprofen administered in previous 6 hours, adjust the dose downward by the amount given by other sources resulting in a maximum of 10mg/Kg
160
Ipratropium BromideClass
Anticholinergic
161
Ipratropium BromideDescription
It is a parasympatholytic bronchodilator that is chemically related to atropine
162
Ipratropium BromidePresentation
0.25mg (250mcg) in 1ml Nebuliser Solution
163
Ipratropium BromideAdministration
Nebulised (NEB) mixed with age specific dose of Salbutamol dose
164
Ipratropium BromideIndications
Acute severs asthma not responding to initial salbutamol dose
165
Ipratropium BromideContraindications
KSAR
166
Ipratropium BromideDosages
Adult: 0.5mg NEBPaed: 0.25mg NEB
167
Ipratropium BromidePharmacology
It blocks muscarinic receptors associated with parasympathetic stimulation of the bronchial air passageways. This results in bronchial dilation and reduced bronchial secretions
168
Ipratropium BromideSide Effects
Transient Dry MouthBlurred VisionTachycardiaHeadache
169
LidocaineClass
Anti-arrhythmic
170
LidocaineDescription
Ventricular anti-arrhythmic agent
171
LidocainePresentation
Lidocaine Injection Minijet 1% w/v 100mg per ml
172
LidocaineAdministration
Intravenous (IV)Intraosseous (IO)
173
LidocaineIndications
When Amiodarone is unavailable it may be substituted with Lidocaine
174
LidocaineContraindications
No contraindications for cardiac arrest
175
LidocaineDosage
Adult: 1 - 1.5mg/Kg IV (Max 3mg/Kg)Paed: not indicated
176
LidocainePharmacology
Reduces automaticity by decreasing the rate of diastolic depolarisation.Stabilises the neuronal membrane and prevents the initiation and transmission of nerve impulses, action is rapid and blockade may last up to 2 hours
177
LidocaineSide Effects
Drowsiness, dizziness, twitching, paraesthesia, convulsionsBradycardiaRespiratory depression
178
LidocaineAdditional Info
Lidocaine may not be administered if Amiodarone has been administrated
179
LorazepamClass
Benzodiazepine
180
LorazepamDescription
It is an anxiolytic used as a sedative
181
LorazepamPresentation
1mg tablet
182
LorazepamAdministration
Orally (PO)
183
LorazepamIndications
Combative with hallucinations or paranoia & risk to self or others
184
LorazepamContraindications
History of sensitivity to benzodiazepinesSevere hepatic or pulmonary insufficiencySuspected significant alcohol and or sedatives ingestedKSAR
185
LorazepamDosage
Adult: 2mg POPaed: not indicated
186
LorazepamPharmacology
Acts on CNS receptors to potentiate the inhibitory action of GABA
187
LorazepamSide Effects
Drowsiness, Confusion, Headache, Dizziness, Blurred Vision and Nausea & VomitingOn rare occasions - hypotension, hypertension
188
Magnesium Sulphate InjectionClass
Electrolyte and Tocolytic agent
189
Magnesium Sulphate InjectionDescription
It is a salt that is an essential element in numerous biochemical reactions that occur within the body
190
Magnesium Sulphate InjectionPresentation
5g in 10mL ampoule
191
Magnesium Sulphate InjectionAdministration
Intravenous (IV)Intraosseous (IO)
192
Magnesium Sulphate InjectionIndications
Torsades de pointesPersistent Bronchospasm
193
Magnesium Sulphate InjectionContraindications
None in cardiac arrestKSAR
194
Magnesium Sulphate InjectionDosage
Adult:Torsades: 2g IV/IO infusion over 15 minutesBronchospasm: 1.5g IV/IO over 20 minutesPaed: not indicated
195
Magnesium Sulphate InjectionPharmacology
It acts as a physiological calcium channel blocker and blocks neuromuscular transmission
196
Magnesium Sulphate InjectionSide Effects
Decreased deep tendon reflexes, respiratory depression, bradycardia and hypothermia
197
Magnesium Sulphate InjectionAdditional Info
Dilute in 100mL NaCl for infusion
198
Midazolam SolutionClass
Benzodiazepine
199
Midazolam SolutionDescription
It is a potent sedative agent. Clinical experience has shown Midazolam to be 3 to 4 times more potent per mg as Diazepam
200
Midazolam SolutionPresentation
10mg in 2ml ampoule or 10mg in 5ml ampoule.Buccal liquid 50mg in 5ml or 10mg in 1ml pre-filled syringe
201
Midazolam SolutionAdministration
Intravenous (IV)Intraosseous (IO)Intramuscular (IM)Buccal (BU)Intranasal (IN) (50% in each nostril)
202
Midazolam SolutionIndications
SeizuresPsychostimulant overdoseHallucinations or paranoia
203
Midazolam SolutionContraindications
ShockDepressed vital signs or alcohol related altered level of consciousnessKSARRespiratory depression
204
Midazolam SolutionDosage
Adult:Seizure: 2.5mg IV or 5mg IM or 10mg BU or 5mg IN (repeat X 1 prn)Psych OD: 2.5mg IV or 5mg IM (repeat X 2 prn)Halllucinations or Paranoia: 5mg IV/IMPaed:Seizure: 0.5mg/Kg BU or 0.2mg/Kg IN or 0.1mg/Kg IV/IO (repeat X 1 prn)
205
Midazolam SolutionPharmacology
It affects the activity of a chemical that transmits impulses across nerve synapses called Gamma-AminoButyric Acid (GABA). GABA is an inhibitory neurotransmitter. Midazolam works by increasing the effects of GABA at these receptors
206
Midazolam SolutionSide Effects
Respiratory DepressionHeadacheHypotensionDrowsiness
207
Midazolam SolutionAdditional Info
Midazolam IV should be titrated to effect. Ensure oxygen and resuscitation equipment are available prior to administration. The max dose of Midazolam includes that administered by caregiver prior to arrival of practitioner
208
MorphineClass
Narcotic Analgesic
209
MorphineDescription
CNS depressant and a potent analgesic with haemodynamic properties that make it extremely useful in emergency medicine
210
MorphinePresentation
Ampoule 10mg in 1ml (dilute in 9ml of NaCl)Supension (10mg/5ml)
211
MorphineAdministration
Intravenous (IV)Intraosseous (IO)Orally (PO)Intramuscular (IM)
212
MorphineIndication
Adult: Severe Pain (≥ 5 on pain scale)Paed: Severe Pain (≥ 6 on pain scale)
213
MorphineContraindication
PO < 1 Year oldKSARBrain InjuryLabour painsAcute alcoholismAcute respiratory drpressionSys BP < 90mmHgMigraine
214
MorphineDosage
Adult: 2mg IV/IO Repeat at not < 2 minute intervals if indicated to Max 10mgFor musculoskeletal pain Max 16mgUp to 10mg IM ( if not cardiac chest pain and no IV access)Paed: 0.3mg/Kg (300mcg/Kg) PO (Max 10mg)0.05mg/Kg (50mcg/Kg) IV/IORepeat at not < 2 min prn to Max of 0.1mg/Kg IV/IO
215
MorphinePharmacology
Opiate AnalgesicActs on CNS to educe pain & anxietyVasodilation resulting in reduced peload to myocardium
216
MorphineSide Effects
Respiratory depressionDrowsinessNausea & vomitingConstipationLTSE - May lead to dependence
217
MorphineAdditional Info
Use with extreme caution particularly with elderly/youngCaution with acute respiratory distressN.B. Controlled under the Misuse of Drugs Act (1977, 1984)
218
NaloxoneClass
Narcotic antagonist
219
NaloxoneDescription
Effective in management and reversal of overdoses caused by narcotics or synthetic narcotic agents
220
NaloxonePresentation
Ampoules 0.4mg in 1mL (400mcg/1mL) Pre-filled syringe
221
NaloxoneAdministration
Intravenous (IV)Intraosseous (IO)Intramuscular (IM)Subcutaneous (SC)
222
NaloxoneIndications
Respiratory rate < 10 secondary to known or suspected narcotic overdose
223
NaloxoneContraindications
KSAR
224
NaloxoneDosage
Adult: 0.4mg IV/IO/IM/SC. Repeat after 3min if indicated to Max 2mg.Paed: 0.01mg/Kg (10mcg/Kg) IV/IO/IM/SC.Repeat dose prn to maintain opoid reversal to max 0.1mg/Kg or 2mg
225
NaloxonePharmacology
Narcotic antagonistReverse the respiratory depression and analgesic effect of narcotics
226
NaloxoneSide Effects
Acute reversal of narcotic effect ranging from nausea & vomiting to agitation & seizures
227
NaloxoneAdditional Info
Use with caution in pregnancyAdminister with caution to patients who have taken large dose of narcotics ar are physically dependent.Rapid reversal will precipitate acute withdrawal syndrome.Prepare to deal with aggressive patients
228
NifedipineClass
Tocolytic agent and calcium channel blocker
229
NifedipineDescription
Dihydropyridine calcium channel blocker
230
NifedipinePresentation
20mg tablet
231
NifedipineAdministration
Orally (PO)
232
Nifedipineindications
Prolapsed cord
233
NifedipineContraindications
HypotensionKSAR
234
NifedipineDosage
Adults: 20mg POPaed: not indicated
235
NifedipinePharmacology
Inhibits muscle contraction by interfering with the movement of calcium ions through the slow channels of active cell membrane
236
NifedipineSide Effects
HypotensionHeadacheBradycardiaNausea & Vomiting
237
NifedipineAdditional Info
Close monitoring of maternal pulse & BP is required and continuous foetal monitoring should be carried out if possible
238
EntonoxClass
Analgesic
239
EntonoxDescription
Potent analgesic gas contains a mixture of both nitrous oxide and oxygen
240
EntonoxPresentation
Cylinder, coloured blue with white anf blue triangles on cylinder shoulders.Medical Gas: 50% Nitrous Oxide & 50% Oxygen
241
EntonoxAdministration
Self administered.Inhalation by demand valve with face mask or mouthpiece
242
EntonoxIndications
Pain Relief
243
EntonoxContraindications
ShockChest Injury / PneumothoraxAltered Level of ConsciousnessRecent Scuba DiveInhalation InjuryDecompression SicknessIntestinal ObstructionCarbon Monoxide poisoningKSAR
244
EntonoxDosage
Self Administered until pain relieved
245
EntonoxPharmacology
Analgesic agent gas:- CNS Depressant- Pain relief
246
EntonoxSide Effects
DisinhibitionDecreased level of consciousnessLight headedness
247
EntonoxAdditional Info
Do not use if patient unable to understand instructions.In cold temperatures, warm cylinder and invert to ensure mix of gases.Advanced paramedics may use discretion with minor chest injuries.Brand name: Entonox.Has an addictive property
248
OndansetronClass
Anti-emetic
249
OndansetronDescription
Used in the management of nausea & vomiting.Potent, highly selective 5HT3 receptor-antagonists
250
OndansetronPresentation
Ampoule 2ml (4mg in 2ml)
251
OndansetronAdministration
Intravenous (IV)
252
OndansetronIndications
Management, prevention and treatment of nausea & vomiting
253
OndansetronContraindications
KSAR
254
OndansetronDosage
Adult: 4mg slow IVPaed: 0.1mg/Kg IV slowly to Max 4mg
255
OndansetronPharmacology
Precise mode of action in the control of nausea & vomiting is not known
256
OndansetronSide Effects
HeadacheSensation of warmthFlushingHiccups
257
OndansetronAdditional Info
None
258
OxygenClass
Gas
259
OxygenDescription
Odourless, tasteless, colourless gas necessary for life
260
OxygenPresentation
D,E, or F cylinders, coloured black with white shouldersCD cylinder; white cylinderMedical Gas
261
OxygenAdministration
Inhalation via:- high concentration reservoir (non-rebreather) mask- simple face mask- venturi mask- tracheostomy mask- nasal cannula- bag valve mask
262
OxygenIndications
Absent/inadequate vebtilation following an cute medical or traumatic event.SpO2 < 94% adults and < 96% paedsSpO2 < 92% for patients with acute exacerbation of COPD
263
OxygenContraindications
Paraquat poisoningBleomycin lung injury
264
OxygenDosage
Adult:Cardiac / Respiratory arrest: 100%Life Threats identified in Primary survey: 100% until reliable SpO2 of 94% - 98%COPD: titrate to 92%Everything else: titrate to 94%- 98%Paed: cardiac/respiratory arrest: 100%Life Threats Prim Surv: 100% titrate to 96% -98%Everything else: titrate to 96% - 98%
265
OxygenPharmacology
Oxygenation of tissue/organs
266
OxygenSide Effects
Prolonged use of O2 with chronic COPD patients may lead to reduction in ventilation stimulus
267
OxygenAdditional Info
A written record must be made of what oxygen therapy is given to every patient. Documentation recording oximetry measurements should state whether patient is breathing air or a specified dose of supplemental oxygen. consider humidifier if O2 therapy for paed patients is > 30 mins duration. Avoid naked flames, powerful oxidising agent.
268
ParacetamolClass
Analgesic and anti-pyretic
269
ParacetamolDescription
Paracetamol is used to reduce pain and body temperature
270
ParacetamolPresentation
Rectal suppository 180mg and 60mg.Suspension 120mg in 5mL.500mg Tablet
271
ParacetamolAdministration
Per rectum (PR)Orally (PO)
272
ParacetamolIndications
Pyrexia following seizure for paed patients.AP's may administer Paracetamol, in the absence of a seizure for the current episode, provided the paediatric patient is pyrexial and has a previous history of febrile convulsions.Minor or moderate pain for adult and paediatric patients
273
ParacetamolContraindications
KSARChronic Liver disease
274
ParacetamolDosage
Adult: 1g POPaed:20mg/Kg PO< 1 Year - 60mg PR1 - 3 Years - 180mg PR4 - 8 Years - 360mg PR
275
ParacetamolPharmacology
Analgesic - central prostaglandin inhibitor.Anti-pyretic - Prevents the hypothalamus from synthesising Prostaglandin E, inhibiting the body temperature from rising further.
276
ParacetamolSide Effects
None.LTSE - Long term use at high dosage or over dosage can cause liver damage and less frequently renal damage
277
ParacetamolAdditional Info
Note: Paracetamol is contained in Paracetamol Suspension and other over the counter drugs.Consult with parent/guardian in relation to medication prior to arrival on scene. For PR use be aware of modesty of patient, should be administered in the presednc of a 2nd person.If paracetamol is administered in previous 4 hours, adjust the dose downward by the amount given by other sources resulting in a maximum of 20mg/Kg
278
SalbutamolClass
Sympathetic agonist
279
SalbutamolDescription
Sympathomimetic that is selective for Beta-2 adrenergic receptors
280
SalbutamolPresentation
Nebule 2.5mg in 2.5mLNebule 5mg in 2.5mLAerosol Inhaler: metered dose 0.1mg
281
SalbutamolAdministration
Inhalation (INH) via nebuliser
282
SalbutamolIndications
BronchospasmExacerbation of COPDRespiratory distress following submersion incident
283
SalbutamolContraindications
KSAR
284
SalbutamolDosage
Adult: 5mg Neb Repeat at 5 min prn (AP X 3, P X 1)Paed: <5 yrs - 2.5mg Neb≥ 5yrs - 5mg Neb Repeat at 5min prn (AP X 3, P X 1)
285
SalbutamolPharmagology
Beta 2 agonistBronchodilationRelaxation of smooth muscle
286
SalbutamolSide Effects
TachycardiaTremorsTachyarrhythmiasLTSE: High doses may cause hpokalaemia
287
SalbutamolAdditional Info
It is more efficient to use a volumiser in conjunction with an aerosol inhaler when administering Salbutamol.If an Oxygen driven nebuliser is used to administer Salbutamol for a patient with acute exacerbation of COPD, it should be limited to 6 minutes maximum
288
Sodium Bicarbonate InjectionClass
Alkalinizing Agent
289
Sodium Bicarbonate InjectionDescription
A salt that is an alkalinizing agent and electrolyte supplement
290
Sodium Bicarbonate InjectionPresentation
Glass vial 8.4% in 50ml
291
Sodium Bicarbonate InjectionAdministration
Intravenous (IV)
292
Sodium Bicarbonate InjectionIndications
Wide complex QRS arrhythmias and/or seizures following tricyclic (TCA) overdoseCardiac arrest following Tricyclic overdose
293
Sodium Bicarbonate InjectionContraindications
KSAR
294
Sodium Bicarbonate InjectionDosage
Adult: 1mEq/Kg (1ml/Kg 8.4% solution)Paed: not indicated
295
Sodium Bicarbonate InjectionPharmacology
TCA excretion from the body is enhanced by making the urine more alkaline (raising the pH)
296
Sodium Bicarbonate InjectionSide Effects
Nil when used for emergencies
297
Sodium Bicarbonate InjectionAdditional Info
None
298
Sodium Chloride 09%Class
Isotonic crystalloid solution
299
Sodium Chloride 09%Description
Solution of sodium and chloride, also known as normal saline (NaCl)
300
Sodium Chloride 09%Presentation
100ml, 500ml, 1000ml soft-pack for infusion10ml Ampoules
301
Sodium Chloride 09%Administration
Intravenous (IV) InfusionIntravenous (IV) FlushIntraosseous (IO)
302
Sodium Chloride 09%Indications
IV/IO fluid for pre-hospital emergency care
303
Sodium Chloride 09%Contraindications
KSAR
304
Sodium Chloride 09%Dosage ADULT
Anaphylaxis: 1000ml (Rpt X 1)Burns: >10% TBSA consider 500ml >25% TBSA & 1 hr from injury to ED, 1000mlCrush Injury: 20ml/KgDecompression Illness:500mlGlycaemic Emergency: 1000mlHypothermia: 250ml (warmed to ≈ 40°C) Max 1000mlKVO or medication flush in Cardiac arrestPost-resus care: 500ml (at ≈ 4°C) Maintain Sys BP >90mmHgShock: 500ml. rpt 250ml to maintain Sys BP of:- 100mmHg (hypovolaemia or septic)- 90 - 100mmHg (Head Inj GCS >8)- 120mmHg (Head Inj GCS ≤8)Cardiac Arrest: 20ml/Kg
305
Sodium Chloride 09%Dosage PAEDIATRIC
Anaphylaxis: 20ml/Kg (Rpt X 1)Burns: >10% TBSA and/or 1 hr from injury to ED:5 ≤ 10 yrs 250ml, >10 yrs 500mlCrush Injury: 20ml/KgGlycaemic Emergency: 20ml/KgHypothermia: 20ml/Kg (warmed to ≈ 40°C) Haemorrhagic shock: 10ml/Kg, rpt if signs of inadequate perfusionKVO or medication flush in Cardiac arrestPost-resus care: 20ml/Kg (at ≈ 4°C) Neonatal Resus: 10ml/KgShock: 20ml/KgCardiac Arrest: 20ml/Kg
306
Sodium Chloride 09%Pharmacology
Isotonic crystalloid solutionFluid replacement
307
Sodium Chloride 09%Side Effects
Excessive volume replacement may lead to heart failure
308
Sodium Chloride 09%Additional Info
NaCl is the IV/IO fluid of choice for pre-hospital emergency care.For KVO use 500ml pack only
309
SyntometrineClass
Synthetic Hormone
310
SyntometrineDescription
Ergometrine maleate 0.5mg and synthetic oxytocin 5 units per mL
311
SyntometrinePresentation
1mL ampoule
312
SyntometrineAdministration
Intramuscular (IM)
313
SyntometrineIndications
Control of post-partum Haemorrhage
314
SyntometrineContraindications
Severe kidney, live or cardiac dysfunction.Sepsis.KSAR
315
SyntometrineDosage
Adult: 1mL IMPaed: not indicated
316
SyntometrinePharmacology
Causes Rhythmic contraction of uterine smooth muscle, thereby constricting uterine blood vessels
317
SyntometrineSide Effects
Nausea & vomitingAbdominal painHeadacheDizzinessCardiac arrhythmias
318
SyntometrineAdditional Info
Ensure that a second foetus is not in the uterus prior to administration
319
TenecteplaseClass
Thrombolytic agent
320
TenecteplaseDescription
A recombinant fibrin-specific plasminogen activator
321
TenecteplasePresentation
Powder and solvent for solution.1 vial contains 10,000 units (50mg) Tenecteplase.1 prefilled syringe contains 10mL water for injections.The reconstituted solution contains 1,000 units (5mg) tenecteplase per mL
322
TenecteplaseAdministration
Intravenous (IV)
323
TenecteplaseIndications
Patient conscious, coherent and understands therapy.Patient consent obtained. 20 mins & ≤ 6 hours.Time to PPCI centre > 90 mins of STEMI confirmation on 12 lead ECG
324
TenecteplaseContraindications
Haemorrhagic stroke or stroke of unknown origin at any time.Ischaemic stroke in previous 6 months.CNS damage or neoplasms.Recent major trauma/ surgery/ head injury (within 3 weeks).GI bleeding within last month.Active peptic ulcer.Known bleeding disorder.Oral anticoagulant therapy.Aortic Dissection.TIA in preceding 6 mths.Pregnancy and within 1 week post partum.Non-compressible punctures.Traumatic resuscitation.Refractory HTN (Sys BP >180mmHg).Advanced liver diseaseInfective endocarditis
325
TenecteplaseDosage
Adult: < 70Kg - 7,000units, 35mg, 7mL70 < 80Kg - 8,000units, 40mg, 8mL80 < 90Kg - 9,000units, 45mg, 9ml≥90Kg - 10,000units, 50mg, 10mLPaed; not indicated
326
TenecteplasePharmacology
Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (Blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus.
327
TenecteplaseSide Effects
Haemorrhage predominantly superficial at the injection site. Ecchymoses are observed commonly but usually do not require any specific action.Stroke (including intracranial bleeding) and other serious bleeding episodes.
328
TenecteplaseAdditional Info
Enoxaparin should be used as antithrombotic adjunctive therapy.
329
Fentanyl | Class
Narcotic analgesic
330
Fentanyl | Description
Synthetic narcotic analgesic with a rapid onset and short durationof action. It has a half-life of 6.5 minutes when IN route is used.
331
Fentanyl | Presentation
100 micrograms in 2 mL ampoule. (0.1 mg in 2 mL)
332
Fentanyl | Administration
Intranasal (IN)
333
Fentanyl | Indications
Acute severe pain in patients between 1 and 16 years old (≥ 1 yearand < 16 years).
334
Fentanyl | Contraindications
``` Known fentanyl hypersensitivity ALoC Bilateral occluded nasal passage Nasal trauma Epistaxis Hypovolaemia. ```
335
Fentanyl | Dosage
Adult: Not applicableAdolescent: (14 to < 16 years)0.0015 mg/Kg (1.5 mcg/Kg) IN. Repeat by one after 10 minutes ifsevere pain persists. Paediatric:0.0015 mg/Kg (1.5 mcg/Kg) IN. Repeat by one after 10 minutes ifsevere pain persists.
336
Fentanyl | Pharmagology
Fentanyl provides some of the effects typical of other opioidsthrough its agonism of the opioid receptors. Its strong potency inrelation to that of morphine is largely due to its high lipophilicity.Because of this, it can more easily penetrate the CNS.Fentanyl binds to μ-opioid G-protein-coupled receptors, whichinhibit pain neurotransmitter release by decreasing intracellularCa2+ levels.
337
Fentanyl | Side Effects
Sedation Nausea & vomiting Respiratory Depression
338
Fentanyl | Additional Info
Caution if patient has transdermal Fentanyl patch. Include an additional 0.1 mL, to allow for dead space in MAD, in the calculated volume required. Administer 50% volume in each nostril if more than 1 mL.
339
Adenosine Class
AntiArrhythmic Agent
340
Adenosine Description
Antiarrhythmic agent used to treat Supraventricular Tachycardia
341
Adenosine Presentation
6mg in 2ml | 3mg/ml solution for infusion vials
342
Adenosine Administration
Intravenous IV
343
Adenosine Indications
Paroxysmal Supraventricular Tachycardia (>150) with signs of poor perfusion
344
Adenosine Contra-indications
``` Asthma Wolff-Parkinson-White Syndrome Chronic Obstructive Pulmonary Disease (COPD) Decompensated Heart Failure Long QT Syndrome 2º & 3º AV Block Severe Hypotension Sick Sinus (unless pacemaker fitted) KSAR ```
345
Adenosine Dose
6mg IV | Repeat @ 12mg x 2 Max
346
Adenosine Pharmacology / Action
Rapid reversion to sinus rhythm of paroxysmal Supraventricular tachycardia
347
Adenosine Side Effects
``` Angina (discontinue) Apprehension - arrhythmia (discontinue if asystole or severe bradycardia occur) AV Block Dizziness Dyspnoea Flushing Headache Nausea Sinus Pause ``` Uncommon: Blurred Vision / Hyperventilation / Metallic Taste / Palpitation / Sweating / Weakness
348
Adenosine Cautions
``` Atrial Fibrillation with accessory pathway Atrial Flutter with accessory pathway AV Block Bundle Branch Block 1º AV Block Heart Transplant Recent MI Severe Heart Failure Stenotic Valvular Heart Disease Uncorrected Hypovolaemia ```